Histidine metabolism drives liver cancer progression via immune microenvironment modulation through metabolic reprogramming

Histidine metabolism drives liver cancer progression via immune microenvironment modulation through metabolic reprogramming

Abstract Background Histidine metabolism is crucial in role in tumor biology, contributing to tumor progression, immune regulation, and metabolic reprogramming. In hepatocellular carcinoma (HCC), dysregulated histidine metabolism may promote tumor growth and immune evasion, although the specific mec...

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Bibliographic Details
Main Authors: Pengcheng Liu, Fuxin Huang, Peixu Lin, Jiayao Liu, Pincheng Zhou, Jie Wang, Huanhuan Sun, Fan Xing, Haiqing Ma
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Journal of Translational Medicine
Subjects:
Histidine metabolism
Hepatocellular carcinoma
Tumor microenvironment
Immune suppression
BUD23
Prognosis
Online Access:https://doi.org/10.1186/s12967-025-06267-y
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