Therapeutic Effects of Rosemary Leaf Extract on Liver and Kidney Parameters of Rats Treated with Cypermethrin
Background: Cypermethrin, a widely used synthetic pyrethroid insecticide, is known to induce hepatotoxicity and nephrotoxicity through oxidative stress and inflammatory pathways. Rosemary (Rosmarinus officinalis) extract has demonstrated antioxidant and anti-inflammatory properties, suggesting pot...
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College of Veterinary Medicine, University of Fallujah
2025-07-01
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| Series: | مجلة الانبار للعلوم البيطرية |
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| Online Access: | https://journals.lww.com/ajvs/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=ArticleViewer&an=02108118-202501000-00007 |
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| _version_ | 1849413120619970560 |
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| author | Somda, Marius K. |
| author_facet | Somda, Marius K. |
| author_sort | Somda, Marius K. |
| collection | DOAJ |
| description | Background: Cypermethrin, a widely used synthetic pyrethroid insecticide, is known to induce hepatotoxicity and nephrotoxicity through
oxidative stress and inflammatory pathways. Rosemary (Rosmarinus officinalis) extract has demonstrated antioxidant and anti-inflammatory
properties, suggesting potential therapeutic benefits against pesticide-induced organ damage. Aims and Objectives: This study aimed to evaluate
the protective effects of rosemary leaf extract on liver and kidney parameters in rats exposed to cypermethrin. Materials and Methods: Forty
male rats (180–220 g) were divided into four groups: control (G1, maize oil), cypermethrin-only (G2, 66.5 mg/kg), and two treatment groups
(G3/G4: cypermethrin + 100/200 mg/kg rosemary extract). Treatments were administered orally for six weeks, after which serum levels of
AST, ALT, ALP, urea, and creatinine were measured. Results: Cypermethrin significantly elevated liver enzymes (AST, ALT, ALP) and kidney
markers (urea, creatinine) in G2 compared to controls (P ≤ 0.05). Co-administration of rosemary extract (G3/G4) dose-dependently reduced
these elevations, with G4 (200 mg/kg) showing near-normalization of parameters. Conclusion: Rosemary extract ameliorated cypermethrininduced hepatic and renal dysfunction, likely due to its antioxidant and anti-inflammatory properties, highlighting its potential as a therapeutic
adjunct against pesticide toxicity |
| format | Article |
| id | doaj-art-29cc63e6726644ee99d890de2c47ddce |
| institution | Kabale University |
| issn | 1999-6527 2707-0603 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | College of Veterinary Medicine, University of Fallujah |
| record_format | Article |
| series | مجلة الانبار للعلوم البيطرية |
| spelling | doaj-art-29cc63e6726644ee99d890de2c47ddce2025-08-20T03:34:13ZengCollege of Veterinary Medicine, University of Fallujahمجلة الانبار للعلوم البيطرية1999-65272707-06032025-07-01181283110.4103/AJVS.AJVS_10_25Therapeutic Effects of Rosemary Leaf Extract on Liver and Kidney Parameters of Rats Treated with CypermethrinSomda, Marius K.0Department of Biochemistry and Microbiology, Laboratory of Biochemistry, Biotechnology, Food Technology and Nutrition, University Joseph KIZERBO, Ouagadougou, Burkina Faso, West AfricaBackground: Cypermethrin, a widely used synthetic pyrethroid insecticide, is known to induce hepatotoxicity and nephrotoxicity through oxidative stress and inflammatory pathways. Rosemary (Rosmarinus officinalis) extract has demonstrated antioxidant and anti-inflammatory properties, suggesting potential therapeutic benefits against pesticide-induced organ damage. Aims and Objectives: This study aimed to evaluate the protective effects of rosemary leaf extract on liver and kidney parameters in rats exposed to cypermethrin. Materials and Methods: Forty male rats (180–220 g) were divided into four groups: control (G1, maize oil), cypermethrin-only (G2, 66.5 mg/kg), and two treatment groups (G3/G4: cypermethrin + 100/200 mg/kg rosemary extract). Treatments were administered orally for six weeks, after which serum levels of AST, ALT, ALP, urea, and creatinine were measured. Results: Cypermethrin significantly elevated liver enzymes (AST, ALT, ALP) and kidney markers (urea, creatinine) in G2 compared to controls (P ≤ 0.05). Co-administration of rosemary extract (G3/G4) dose-dependently reduced these elevations, with G4 (200 mg/kg) showing near-normalization of parameters. Conclusion: Rosemary extract ameliorated cypermethrininduced hepatic and renal dysfunction, likely due to its antioxidant and anti-inflammatory properties, highlighting its potential as a therapeutic adjunct against pesticide toxicityhttps://journals.lww.com/ajvs/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=ArticleViewer&an=02108118-202501000-00007cypermethrinkidney and rosemary |
| spellingShingle | Somda, Marius K. Therapeutic Effects of Rosemary Leaf Extract on Liver and Kidney Parameters of Rats Treated with Cypermethrin مجلة الانبار للعلوم البيطرية cypermethrin kidney and rosemary |
| title | Therapeutic Effects of Rosemary Leaf Extract on Liver and Kidney Parameters of Rats Treated with Cypermethrin |
| title_full | Therapeutic Effects of Rosemary Leaf Extract on Liver and Kidney Parameters of Rats Treated with Cypermethrin |
| title_fullStr | Therapeutic Effects of Rosemary Leaf Extract on Liver and Kidney Parameters of Rats Treated with Cypermethrin |
| title_full_unstemmed | Therapeutic Effects of Rosemary Leaf Extract on Liver and Kidney Parameters of Rats Treated with Cypermethrin |
| title_short | Therapeutic Effects of Rosemary Leaf Extract on Liver and Kidney Parameters of Rats Treated with Cypermethrin |
| title_sort | therapeutic effects of rosemary leaf extract on liver and kidney parameters of rats treated with cypermethrin |
| topic | cypermethrin kidney and rosemary |
| url | https://journals.lww.com/ajvs/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=ArticleViewer&an=02108118-202501000-00007 |
| work_keys_str_mv | AT somdamariusk therapeuticeffectsofrosemaryleafextractonliverandkidneyparametersofratstreatedwithcypermethrin |