Therapeutic Effects of Rosemary Leaf Extract on Liver and Kidney Parameters of Rats Treated with Cypermethrin
Background: Cypermethrin, a widely used synthetic pyrethroid insecticide, is known to induce hepatotoxicity and nephrotoxicity through oxidative stress and inflammatory pathways. Rosemary (Rosmarinus officinalis) extract has demonstrated antioxidant and anti-inflammatory properties, suggesting pot...
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| Main Author: | |
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| Format: | Article |
| Language: | English |
| Published: |
College of Veterinary Medicine, University of Fallujah
2025-07-01
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| Series: | مجلة الانبار للعلوم البيطرية |
| Subjects: | |
| Online Access: | https://journals.lww.com/ajvs/_layouts/15/oaks.journals/downloadpdf.aspx?trckng_src_pg=ArticleViewer&an=02108118-202501000-00007 |
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| Summary: | Background: Cypermethrin, a widely used synthetic pyrethroid insecticide, is known to induce hepatotoxicity and nephrotoxicity through
oxidative stress and inflammatory pathways. Rosemary (Rosmarinus officinalis) extract has demonstrated antioxidant and anti-inflammatory
properties, suggesting potential therapeutic benefits against pesticide-induced organ damage. Aims and Objectives: This study aimed to evaluate
the protective effects of rosemary leaf extract on liver and kidney parameters in rats exposed to cypermethrin. Materials and Methods: Forty
male rats (180–220 g) were divided into four groups: control (G1, maize oil), cypermethrin-only (G2, 66.5 mg/kg), and two treatment groups
(G3/G4: cypermethrin + 100/200 mg/kg rosemary extract). Treatments were administered orally for six weeks, after which serum levels of
AST, ALT, ALP, urea, and creatinine were measured. Results: Cypermethrin significantly elevated liver enzymes (AST, ALT, ALP) and kidney
markers (urea, creatinine) in G2 compared to controls (P ≤ 0.05). Co-administration of rosemary extract (G3/G4) dose-dependently reduced
these elevations, with G4 (200 mg/kg) showing near-normalization of parameters. Conclusion: Rosemary extract ameliorated cypermethrininduced hepatic and renal dysfunction, likely due to its antioxidant and anti-inflammatory properties, highlighting its potential as a therapeutic
adjunct against pesticide toxicity |
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| ISSN: | 1999-6527 2707-0603 |