Effectiveness and safety of a novel dexamethasone mouthwash formulation in managing stomatitis in cancer patients
<p><strong>Objective:</strong> To present a new dexamethasone mouthwash formulation and analyze its effectiveness and safety among patients receiving stomatitis-producing antineoplastic agents.</p><p><br /><strong>Method:</strong> Prospective obser...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2021-01-01
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| Series: | Farmacia Hospitalaria |
| Subjects: | |
| Online Access: | http://www.aulamedica.es/fh/pdf/11460.pdf |
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| Summary: | <p><strong>Objective:</strong> To present a new dexamethasone mouthwash formulation and analyze its effectiveness and safety among patients
receiving stomatitis-producing antineoplastic agents.</p><p><br /><strong>Method:</strong> Prospective observational study conducted in a university
hospital between March 2017 and November 2019. Consecutive patients starting everolimus were enrolled. Patients were instructed to rinse
dexamethasone mouthwash formulation twice daily until discontinuation of everolimus. A second cohort of patients with existing stomatitis induced by high
probability of producing stomatitis chemotherapy therapies was also recruited to assess treatment effectiveness. Effectiveness and safety of dexamethasone
mouthwash formulation was assessed.</p><p><strong>Results:</strong> Dexamethasone mouthwash formulation was prescribed in nine patients as
prophylaxis. Six patients were diagnosed with breast cancer, two with neuroendocrine tumor and one with renal cell carcinoma. Four patients developed mild
stomatitis (grade 1-2) and three patients discontinued everolimus due to other treatment-related adverse events. In addition, dexamethasone mouthwash
formulation was prescribed as treatment in five patients with existing stomatitis. All patients achieved a significant reduction in the severity of stomatitis after
starting the dexamethasone mouthwash formulation. In both cohorts, dexamethasone mouthwash formulation was well tolerated and neither dose reduction
nor discontinuation related to stomatitis was required.</p><p><strong>Conclusions:</strong> Dexamethasone mouthwash formulation could be
considered as a suitable alternative for stomatitis management.</p><p> </p> |
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| ISSN: | 1130-6343 2171-8695 |