A Survey of Large Language Model for Drug Research and Development
Drug research and development (drug R&D) is a sophisticated, cost-intensive, and time-consuming procedure with historically low success rates. The advent of Artificial Intelligence (AI) technologies has introduced innovative methods into drug R&D, particularly by leveraging AI...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IEEE
2025-01-01
|
| Series: | IEEE Access |
| Subjects: | |
| Online Access: | https://ieeexplore.ieee.org/document/10930479/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850275823837249536 |
|---|---|
| author | Huijie Guo Xudong Xing Yongjie Zhou Wenjiao Jiang Xiaoyi Chen Ting Wang Zixuan Jiang Yibing Wang Junyan Hou Yukun Jiang Jianzhen Xu |
| author_facet | Huijie Guo Xudong Xing Yongjie Zhou Wenjiao Jiang Xiaoyi Chen Ting Wang Zixuan Jiang Yibing Wang Junyan Hou Yukun Jiang Jianzhen Xu |
| author_sort | Huijie Guo |
| collection | DOAJ |
| description | Drug research and development (drug R&D) is a sophisticated, cost-intensive, and time-consuming procedure with historically low success rates. The advent of Artificial Intelligence (AI) technologies has introduced innovative methods into drug R&D, particularly by leveraging AI capabilities. Large language models (LLMs), a breakthrough in generative AI, have revolutionized drug discovery. With their extensive datasets, numerous parameters, and strong multitasking abilities, LLMs have significantly improved efficiency across various related domains, providing unparalleled support to drug R&D. These models have facilitated a deeper understanding of intricate disease mechanisms and the identification of novel therapeutic strategies, ushering in a new era in drug development and clinical applications. As a result, the advancement of LLMs is poised to drive significant transformations in drug R&D, emphasizing the importance of effectively leveraging this technology. This review provides insights into the architecture and characteristics of LLMs, explores their applications in drug R&D, and highlights their research implications in bioinformatics data, including proteins, genes, and chemical compounds. Furthermore, it investigates the practical strategies of LLMs in drug discovery, drug repositioning, and clinical inquiries, presenting an innovative approach to research and future advancements in this field. |
| format | Article |
| id | doaj-art-29c2862f905047c2812ec982defb461e |
| institution | OA Journals |
| issn | 2169-3536 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IEEE |
| record_format | Article |
| series | IEEE Access |
| spelling | doaj-art-29c2862f905047c2812ec982defb461e2025-08-20T01:50:33ZengIEEEIEEE Access2169-35362025-01-0113511105112910.1109/ACCESS.2025.355225610930479A Survey of Large Language Model for Drug Research and DevelopmentHuijie Guo0https://orcid.org/0009-0005-9967-4316Xudong Xing1https://orcid.org/0000-0002-3081-1694Yongjie Zhou2Wenjiao Jiang3Xiaoyi Chen4Ting Wang5Zixuan Jiang6Yibing Wang7Junyan Hou8Yukun Jiang9Jianzhen Xu10Information Construction Management Office, China Pharmaceutical University, Nanjing, Jiangsu, ChinaState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, ChinaCollege of Science, China Pharmaceutical University, Nanjing, Jiangsu, ChinaCenter for Excellence in Molecular Cell Science, Chinese Academy of Sciences, Shanghai, ChinaCollege of Science, China Pharmaceutical University, Nanjing, Jiangsu, ChinaState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, ChinaState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, ChinaState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, ChinaState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, ChinaState Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, ChinaCollege of Science, China Pharmaceutical University, Nanjing, Jiangsu, ChinaDrug research and development (drug R&D) is a sophisticated, cost-intensive, and time-consuming procedure with historically low success rates. The advent of Artificial Intelligence (AI) technologies has introduced innovative methods into drug R&D, particularly by leveraging AI capabilities. Large language models (LLMs), a breakthrough in generative AI, have revolutionized drug discovery. With their extensive datasets, numerous parameters, and strong multitasking abilities, LLMs have significantly improved efficiency across various related domains, providing unparalleled support to drug R&D. These models have facilitated a deeper understanding of intricate disease mechanisms and the identification of novel therapeutic strategies, ushering in a new era in drug development and clinical applications. As a result, the advancement of LLMs is poised to drive significant transformations in drug R&D, emphasizing the importance of effectively leveraging this technology. This review provides insights into the architecture and characteristics of LLMs, explores their applications in drug R&D, and highlights their research implications in bioinformatics data, including proteins, genes, and chemical compounds. Furthermore, it investigates the practical strategies of LLMs in drug discovery, drug repositioning, and clinical inquiries, presenting an innovative approach to research and future advancements in this field.https://ieeexplore.ieee.org/document/10930479/Large modelartificial intelligencetransformerdrug research and development |
| spellingShingle | Huijie Guo Xudong Xing Yongjie Zhou Wenjiao Jiang Xiaoyi Chen Ting Wang Zixuan Jiang Yibing Wang Junyan Hou Yukun Jiang Jianzhen Xu A Survey of Large Language Model for Drug Research and Development IEEE Access Large model artificial intelligence transformer drug research and development |
| title | A Survey of Large Language Model for Drug Research and Development |
| title_full | A Survey of Large Language Model for Drug Research and Development |
| title_fullStr | A Survey of Large Language Model for Drug Research and Development |
| title_full_unstemmed | A Survey of Large Language Model for Drug Research and Development |
| title_short | A Survey of Large Language Model for Drug Research and Development |
| title_sort | survey of large language model for drug research and development |
| topic | Large model artificial intelligence transformer drug research and development |
| url | https://ieeexplore.ieee.org/document/10930479/ |
| work_keys_str_mv | AT huijieguo asurveyoflargelanguagemodelfordrugresearchanddevelopment AT xudongxing asurveyoflargelanguagemodelfordrugresearchanddevelopment AT yongjiezhou asurveyoflargelanguagemodelfordrugresearchanddevelopment AT wenjiaojiang asurveyoflargelanguagemodelfordrugresearchanddevelopment AT xiaoyichen asurveyoflargelanguagemodelfordrugresearchanddevelopment AT tingwang asurveyoflargelanguagemodelfordrugresearchanddevelopment AT zixuanjiang asurveyoflargelanguagemodelfordrugresearchanddevelopment AT yibingwang asurveyoflargelanguagemodelfordrugresearchanddevelopment AT junyanhou asurveyoflargelanguagemodelfordrugresearchanddevelopment AT yukunjiang asurveyoflargelanguagemodelfordrugresearchanddevelopment AT jianzhenxu asurveyoflargelanguagemodelfordrugresearchanddevelopment AT huijieguo surveyoflargelanguagemodelfordrugresearchanddevelopment AT xudongxing surveyoflargelanguagemodelfordrugresearchanddevelopment AT yongjiezhou surveyoflargelanguagemodelfordrugresearchanddevelopment AT wenjiaojiang surveyoflargelanguagemodelfordrugresearchanddevelopment AT xiaoyichen surveyoflargelanguagemodelfordrugresearchanddevelopment AT tingwang surveyoflargelanguagemodelfordrugresearchanddevelopment AT zixuanjiang surveyoflargelanguagemodelfordrugresearchanddevelopment AT yibingwang surveyoflargelanguagemodelfordrugresearchanddevelopment AT junyanhou surveyoflargelanguagemodelfordrugresearchanddevelopment AT yukunjiang surveyoflargelanguagemodelfordrugresearchanddevelopment AT jianzhenxu surveyoflargelanguagemodelfordrugresearchanddevelopment |