Elevated Adiponectin Serum Levels in Women with Systemic Autoimmune Diseases
Adipose tissue produces a wide range of proteins that may influence the immune system. In this study, we assessed the serum levels of leptin, adiponectin, and ghrelin, in association with the measurements of body composition, in 15 female patients with various autoimmune diseases (systemic lupus ery...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2010-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2010/938408 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832567024291676160 |
|---|---|
| author | Éric Toussirot Béatrice Gaugler Malika Bouhaddi Nhu Uyen Nguyen Philippe Saas Gilles Dumoulin |
| author_facet | Éric Toussirot Béatrice Gaugler Malika Bouhaddi Nhu Uyen Nguyen Philippe Saas Gilles Dumoulin |
| author_sort | Éric Toussirot |
| collection | DOAJ |
| description | Adipose tissue produces a wide range of proteins that may influence the immune system. In this study, we assessed the serum levels of leptin, adiponectin, and ghrelin, in association with the measurements of body composition, in 15 female patients with various autoimmune diseases (systemic lupus erythematosus, primary Sjögren's syndrome, sarcoidosis, mixed connective tissue disease, vasculitis, CREST syndrome, and polymyositis) and in 15 healthy female controls. There were no statistically significant differences between the patients and controls with regard to serum leptin, serum ghrelin, global fat mass, adiposity, and fat mass in the android or gynoid regions, whereas serum adiponectin levels were higher in patients than controls (16.3±1.6 μg/mL versus 9.7±0.6 μg/mL; 𝑃=.01). As adiponectin is known to exhibit potent anti-inflammatory properties, a high adiponectinemia in patients with systemic autoimmune disease may mitigate the inflammatory response. However, the precise consequences of these elevated serum adiponectin levels on the metabolic syndrome development and atherosclerotic cardiovascular risk in this patient population still needs to be determined. |
| format | Article |
| id | doaj-art-29be592ecb384dbf88ac1673bf9ee0e2 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-29be592ecb384dbf88ac1673bf9ee0e22025-02-03T01:02:31ZengWileyMediators of Inflammation0962-93511466-18612010-01-01201010.1155/2010/938408938408Elevated Adiponectin Serum Levels in Women with Systemic Autoimmune DiseasesÉric Toussirot0Béatrice Gaugler1Malika Bouhaddi2Nhu Uyen Nguyen3Philippe Saas4Gilles Dumoulin5Department of Rheumatology, University Hospital Jean Minjoz, Bd Fleming, 25030 Besançon Cedex, FranceUniversity Hospital St Jacques, CIC Biotherapy-CBT 506, 25030 Besançon Cedex, FranceDepartment of Physiology, University Hospital Jean Minjoz, Bd Fleming, 25030 Besançon Cedex, FranceDepartment of Physiology, University Hospital Jean Minjoz, Bd Fleming, 25030 Besançon Cedex, FranceUniversity Hospital St Jacques, CIC Biotherapy-CBT 506, 25030 Besançon Cedex, FranceDepartment of Physiology, University Hospital Jean Minjoz, Bd Fleming, 25030 Besançon Cedex, FranceAdipose tissue produces a wide range of proteins that may influence the immune system. In this study, we assessed the serum levels of leptin, adiponectin, and ghrelin, in association with the measurements of body composition, in 15 female patients with various autoimmune diseases (systemic lupus erythematosus, primary Sjögren's syndrome, sarcoidosis, mixed connective tissue disease, vasculitis, CREST syndrome, and polymyositis) and in 15 healthy female controls. There were no statistically significant differences between the patients and controls with regard to serum leptin, serum ghrelin, global fat mass, adiposity, and fat mass in the android or gynoid regions, whereas serum adiponectin levels were higher in patients than controls (16.3±1.6 μg/mL versus 9.7±0.6 μg/mL; 𝑃=.01). As adiponectin is known to exhibit potent anti-inflammatory properties, a high adiponectinemia in patients with systemic autoimmune disease may mitigate the inflammatory response. However, the precise consequences of these elevated serum adiponectin levels on the metabolic syndrome development and atherosclerotic cardiovascular risk in this patient population still needs to be determined.http://dx.doi.org/10.1155/2010/938408 |
| spellingShingle | Éric Toussirot Béatrice Gaugler Malika Bouhaddi Nhu Uyen Nguyen Philippe Saas Gilles Dumoulin Elevated Adiponectin Serum Levels in Women with Systemic Autoimmune Diseases Mediators of Inflammation |
| title | Elevated Adiponectin Serum Levels in Women with Systemic Autoimmune Diseases |
| title_full | Elevated Adiponectin Serum Levels in Women with Systemic Autoimmune Diseases |
| title_fullStr | Elevated Adiponectin Serum Levels in Women with Systemic Autoimmune Diseases |
| title_full_unstemmed | Elevated Adiponectin Serum Levels in Women with Systemic Autoimmune Diseases |
| title_short | Elevated Adiponectin Serum Levels in Women with Systemic Autoimmune Diseases |
| title_sort | elevated adiponectin serum levels in women with systemic autoimmune diseases |
| url | http://dx.doi.org/10.1155/2010/938408 |
| work_keys_str_mv | AT erictoussirot elevatedadiponectinserumlevelsinwomenwithsystemicautoimmunediseases AT beatricegaugler elevatedadiponectinserumlevelsinwomenwithsystemicautoimmunediseases AT malikabouhaddi elevatedadiponectinserumlevelsinwomenwithsystemicautoimmunediseases AT nhuuyennguyen elevatedadiponectinserumlevelsinwomenwithsystemicautoimmunediseases AT philippesaas elevatedadiponectinserumlevelsinwomenwithsystemicautoimmunediseases AT gillesdumoulin elevatedadiponectinserumlevelsinwomenwithsystemicautoimmunediseases |