Clinical Evaluation, Diagnosis and Treatment of Pheochromocytoma

Pheochromocytomas are rare neuroendocrine tumors that originate in chromaffin cells of the adrenal medulla and excessively secrete catecholamines, which leads to a multitude of different symptoms. The most common symptoms include headaches, palpitations, and sweating. Because of a diverse clinica...

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Main Authors: Romana Marušić, Tajana Turk, Tatjana Bačun
Format: Article
Language:English
Published: Sestre Milosrdnice University hospital, Institute of Clinical Medical Research 2024-01-01
Series:Acta Clinica Croatica
Subjects:
Online Access:https://hrcak.srce.hr/file/481698
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author Romana Marušić
Tajana Turk
Tatjana Bačun
author_facet Romana Marušić
Tajana Turk
Tatjana Bačun
author_sort Romana Marušić
collection DOAJ
description Pheochromocytomas are rare neuroendocrine tumors that originate in chromaffin cells of the adrenal medulla and excessively secrete catecholamines, which leads to a multitude of different symptoms. The most common symptoms include headaches, palpitations, and sweating. Because of a diverse clinical presentation, pheochromocytomas pose a major diagnostic challenge and often go unidentified. These tumors can occur sporadically or as a part of hereditary syndromes. The diagnosis is confirmed by measuring plasma and 24-hour urinary metanephrine and normetanephrine. Computed tomography, magnetic resonance imaging, and functional morphological examinations are used for tumor localization. The treatment is operative and requires special preoperative patient preparation to prevent hypertensive crisis and arrhythmias. Due to the possibility of recurrence, the patient needs to be monitored. Pheochromocytoma has a high fatality rate if not recognized on time due to the effect of catecholamines on the cardiovascular system.
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publisher Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
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spelling doaj-art-29bdceccf0da4f06b1bd86fec42bca902025-08-20T03:50:01ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512024-01-0163.3-450151110.20471/acc.2024.63.03-04.07Clinical Evaluation, Diagnosis and Treatment of PheochromocytomaRomana Marušić0Tajana Turk1Tatjana Bačun2School of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, CroatiaSchool of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Radiology, Osijek University Hospital Center, Osijek, CroatiaSchool of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; Department of Internal Medicine, Osijek University Hospital Center, Osijek, CroatiaPheochromocytomas are rare neuroendocrine tumors that originate in chromaffin cells of the adrenal medulla and excessively secrete catecholamines, which leads to a multitude of different symptoms. The most common symptoms include headaches, palpitations, and sweating. Because of a diverse clinical presentation, pheochromocytomas pose a major diagnostic challenge and often go unidentified. These tumors can occur sporadically or as a part of hereditary syndromes. The diagnosis is confirmed by measuring plasma and 24-hour urinary metanephrine and normetanephrine. Computed tomography, magnetic resonance imaging, and functional morphological examinations are used for tumor localization. The treatment is operative and requires special preoperative patient preparation to prevent hypertensive crisis and arrhythmias. Due to the possibility of recurrence, the patient needs to be monitored. Pheochromocytoma has a high fatality rate if not recognized on time due to the effect of catecholamines on the cardiovascular system.https://hrcak.srce.hr/file/481698PheochromocytomaHeadacheMultiple endocrine neoplasia type 2PalpitationsParoxysmal hypertension
spellingShingle Romana Marušić
Tajana Turk
Tatjana Bačun
Clinical Evaluation, Diagnosis and Treatment of Pheochromocytoma
Acta Clinica Croatica
Pheochromocytoma
Headache
Multiple endocrine neoplasia type 2
Palpitations
Paroxysmal hypertension
title Clinical Evaluation, Diagnosis and Treatment of Pheochromocytoma
title_full Clinical Evaluation, Diagnosis and Treatment of Pheochromocytoma
title_fullStr Clinical Evaluation, Diagnosis and Treatment of Pheochromocytoma
title_full_unstemmed Clinical Evaluation, Diagnosis and Treatment of Pheochromocytoma
title_short Clinical Evaluation, Diagnosis and Treatment of Pheochromocytoma
title_sort clinical evaluation diagnosis and treatment of pheochromocytoma
topic Pheochromocytoma
Headache
Multiple endocrine neoplasia type 2
Palpitations
Paroxysmal hypertension
url https://hrcak.srce.hr/file/481698
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