Comparative analysis of EEG in patients with schizophrenia receiving various atypical antipsychotics
Aim. To conduct a comprehensive analysis of EEG recordings of schizophrenia patients receiving atypical antipsychotics as monotherapy.Materials and methods. We examined 94 patients with schizophrenia aged 33 [28; 40] years with a disease duration of 10 [4; 15] years. The patients were divided into 5...
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Siberian State Medical University (Tomsk)
2024-04-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/5520 |
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| author | S. A. Galkin E. G. Kornetova S. A. Ivanova |
| author_facet | S. A. Galkin E. G. Kornetova S. A. Ivanova |
| author_sort | S. A. Galkin |
| collection | DOAJ |
| description | Aim. To conduct a comprehensive analysis of EEG recordings of schizophrenia patients receiving atypical antipsychotics as monotherapy.Materials and methods. We examined 94 patients with schizophrenia aged 33 [28; 40] years with a disease duration of 10 [4; 15] years. The patients were divided into 5 groups depending on the antipsychotic drugs they took: 1) risperidone – 31 patients; 2) quetiapine – 20 patients; 3) aripiprazole – 11 patients; 4) olanzapine – 13 patients; 5) clozapine – 19 patients. EEG was recorded during wakefulness with closed eyes (background test), 3-minute hyperventilation, and rhythmic photostimulation in all patients. To describe and interpret the received recordings, the EEG classification according to J. Micoulaud – Franchi et al. was used.Results. EEG modifications (score > 1A) were observed in 61.7% (n = 58) of patients. In the group of patients receiving risperidone, EEG modifications were found in 48.4% of cases, in patients taking quetiapine – in 70% of cases, aripiprazole – in 63.6% of cases, olanzapine – in 61.5% of cases, clozapine – in 73.7% of cases. The frequency of epileptiform patterns in patients receiving olanzapine was significantly higher than in those taking risperidone (p = 0.033) and clozapine (p = 0.032). Slowing in the EEG (score > 1) was more often observed in patients taking clozapine – 63.2% (n = 12), olanzapine – 61.5% (n = 8), and quetiapine – 60% (n = 12). Slower EEG waves were less common in patients receiving aripiprazole – 45.5% (n = 5) and risperidone – 45.2% (n = 14). In the group of patients with EEG slowing (score > 1), the dose of chlorpromazine equivalent was significantly greater compared to patients with normal EEG (p = 0.00046).Conclusion. The data obtained demonstrate changes in EEG parameters during monotherapy with atypical antipsychotics and indicate their dose-dependent effect on the bioelectrical activity of the brain. |
| format | Article |
| id | doaj-art-29b8304afa9b45d8bb93731babbefb44 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-29b8304afa9b45d8bb93731babbefb442025-08-20T04:00:12ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842024-04-01231152210.20538/1682-0363-2024-1-15-223048Comparative analysis of EEG in patients with schizophrenia receiving various atypical antipsychoticsS. A. Galkin0E. G. Kornetova1S. A. Ivanova2Mental Health Research Institute, Tomsk National Research Medical Center (NRMC) of the Russian Academy of SciencesMental Health Research Institute, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences; Siberian State Medical UniversityMental Health Research Institute, Tomsk National Research Medical Center (NRMC) of the Russian Academy of Sciences; Siberian State Medical UniversityAim. To conduct a comprehensive analysis of EEG recordings of schizophrenia patients receiving atypical antipsychotics as monotherapy.Materials and methods. We examined 94 patients with schizophrenia aged 33 [28; 40] years with a disease duration of 10 [4; 15] years. The patients were divided into 5 groups depending on the antipsychotic drugs they took: 1) risperidone – 31 patients; 2) quetiapine – 20 patients; 3) aripiprazole – 11 patients; 4) olanzapine – 13 patients; 5) clozapine – 19 patients. EEG was recorded during wakefulness with closed eyes (background test), 3-minute hyperventilation, and rhythmic photostimulation in all patients. To describe and interpret the received recordings, the EEG classification according to J. Micoulaud – Franchi et al. was used.Results. EEG modifications (score > 1A) were observed in 61.7% (n = 58) of patients. In the group of patients receiving risperidone, EEG modifications were found in 48.4% of cases, in patients taking quetiapine – in 70% of cases, aripiprazole – in 63.6% of cases, olanzapine – in 61.5% of cases, clozapine – in 73.7% of cases. The frequency of epileptiform patterns in patients receiving olanzapine was significantly higher than in those taking risperidone (p = 0.033) and clozapine (p = 0.032). Slowing in the EEG (score > 1) was more often observed in patients taking clozapine – 63.2% (n = 12), olanzapine – 61.5% (n = 8), and quetiapine – 60% (n = 12). Slower EEG waves were less common in patients receiving aripiprazole – 45.5% (n = 5) and risperidone – 45.2% (n = 14). In the group of patients with EEG slowing (score > 1), the dose of chlorpromazine equivalent was significantly greater compared to patients with normal EEG (p = 0.00046).Conclusion. The data obtained demonstrate changes in EEG parameters during monotherapy with atypical antipsychotics and indicate their dose-dependent effect on the bioelectrical activity of the brain.https://bulletin.ssmu.ru/jour/article/view/5520schizophreniaantipsychoticstherapyelectroencephalographyslowingparoxysmal activity |
| spellingShingle | S. A. Galkin E. G. Kornetova S. A. Ivanova Comparative analysis of EEG in patients with schizophrenia receiving various atypical antipsychotics Бюллетень сибирской медицины schizophrenia antipsychotics therapy electroencephalography slowing paroxysmal activity |
| title | Comparative analysis of EEG in patients with schizophrenia receiving various atypical antipsychotics |
| title_full | Comparative analysis of EEG in patients with schizophrenia receiving various atypical antipsychotics |
| title_fullStr | Comparative analysis of EEG in patients with schizophrenia receiving various atypical antipsychotics |
| title_full_unstemmed | Comparative analysis of EEG in patients with schizophrenia receiving various atypical antipsychotics |
| title_short | Comparative analysis of EEG in patients with schizophrenia receiving various atypical antipsychotics |
| title_sort | comparative analysis of eeg in patients with schizophrenia receiving various atypical antipsychotics |
| topic | schizophrenia antipsychotics therapy electroencephalography slowing paroxysmal activity |
| url | https://bulletin.ssmu.ru/jour/article/view/5520 |
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