Extracellular vesicle-packaged GBP2 from macrophages aggravates sepsis-induced acute lung injury by promoting ferroptosis in pulmonary vascular endothelial cells

Extracellular vesicle-packaged GBP2 from macrophages aggravates sepsis-induced acute lung injury by promoting ferroptosis in pulmonary vascular endothelial cells

Macrophages play a critical role in the development of sepsis-induced acute lung injury (si-ALI), with extracellular vesicles (EVs) acting as crucial mediators. However, the effects and mechanisms of macrophage-derived EVs on si-ALI remain unclear. This study demonstrated that macrophage-derived EVs...

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Bibliographic Details
Main Authors: Zhixi Li, Yue Bu, Cheng Wang, Yongjing Yu, Lei Han, Chang Liu, Guangmin Chen, Chenglong Li, Yan Zhang, Hang Cao, Zhaoxue Ma, Ziyong Yue
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Redox Biology
Subjects:
Sepsis
Acute lung injury
Macrophage
Endothelial cells
Extracellular vesicles
Ferroptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725001272
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