Reverse vaccinology-based design of multivalent multiepitope mRNA vaccines targeting key viral proteins of Herpes Simplex Virus type-2

Reverse vaccinology-based design of multivalent multiepitope mRNA vaccines targeting key viral proteins of Herpes Simplex Virus type-2

IntroductionHerpes Simplex Virus type 2 or HSV-2 is a major cause of genital herpes, contributing to increased susceptibility to HIV, encephalitis, and other severe complications. Despite the availability of antiviral therapies such as acyclovir, their effectiveness is limited due to resistance and...

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Main Authors: N. S. Suneesh, Kishore Dhotre, Pratik Mahajan, Debashree Dass, Anwesha Banerjee, Nikhat J. Siddiqi, Abdul Malik, Manali Joshi, Abdul Arif Khan, Vijay Nema, Anupam Mukherjee
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
HSV-2
mRNA vaccine
reverse vaccinology
multiepitope vaccine
immunoinformatics
vaccine design
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1586271/full
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