Unveiling the anticancer potential of flavonoids in hepatocellular carcinoma through microbiome and spatially resolved metabolomics analysis
Abstract Background Hepatocellular carcinoma (HCC) causes a large worldwide health burden, needing novel ways to prevention and treatment. Traditional Chinese medicine, which is rich in bioactive substances, has emerged as a viable approach to tackling HCC difficulties. Artemisia rupestris L. (AR),...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-07-01
|
| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-025-03159-x |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849342964189364224 |
|---|---|
| author | Lina You WuKui Huang ShuYing Chen |
| author_facet | Lina You WuKui Huang ShuYing Chen |
| author_sort | Lina You |
| collection | DOAJ |
| description | Abstract Background Hepatocellular carcinoma (HCC) causes a large worldwide health burden, needing novel ways to prevention and treatment. Traditional Chinese medicine, which is rich in bioactive substances, has emerged as a viable approach to tackling HCC difficulties. Artemisia rupestris L. (AR), a perennial plant, has received interest for its immunoregulatory qualities and potential protection against viral influenza and hepatocellular cancer. Methods In this work, we looked at the pharmacological effects of Artemisia rupestris L. extract (ARE) on HCC mice. We used 16 S rRNA sequencing and computational biology approaches to investigate ARE-induced changes in bacterial composition inside HCC mouse tissues. Furthermore, we used liquid chromatography tandem mass spectrometry (UPLC-MS/MS) to identify metabolic changes caused by ARE. Results Our data indicate that ARE affects hepatocellular cancer via several pathways. AR offers a multi-faceted strategy to combating HCC by influencing critical metabolic pathways such α-linolenic acid and glycerophospholipid metabolism. Conclusions This research sheds new light on Artemisia rupestris L.‘s anticancer potential, setting the platform for a more in-depth knowledge of its influence on hepatocellular carcinoma using a multi-omics approach. |
| format | Article |
| id | doaj-art-29a6bdcd32fd4be8872128018020b777 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-29a6bdcd32fd4be8872128018020b7772025-08-20T03:43:11ZengSpringerDiscover Oncology2730-60112025-07-0116111110.1007/s12672-025-03159-xUnveiling the anticancer potential of flavonoids in hepatocellular carcinoma through microbiome and spatially resolved metabolomics analysisLina You0WuKui Huang1ShuYing Chen2Traditional Chinese Medicine Oncology Department, The Affiliated Cancer Hospital of Xinjiang Medical UniversityInterventional Diagnosis and Treatment Department, The Affiliated Cancer Hospital of Xinjiang Medical UniversityThird Clinical Medical College of Xinjiang Medical University (Affiliated Cancer Hospital)Abstract Background Hepatocellular carcinoma (HCC) causes a large worldwide health burden, needing novel ways to prevention and treatment. Traditional Chinese medicine, which is rich in bioactive substances, has emerged as a viable approach to tackling HCC difficulties. Artemisia rupestris L. (AR), a perennial plant, has received interest for its immunoregulatory qualities and potential protection against viral influenza and hepatocellular cancer. Methods In this work, we looked at the pharmacological effects of Artemisia rupestris L. extract (ARE) on HCC mice. We used 16 S rRNA sequencing and computational biology approaches to investigate ARE-induced changes in bacterial composition inside HCC mouse tissues. Furthermore, we used liquid chromatography tandem mass spectrometry (UPLC-MS/MS) to identify metabolic changes caused by ARE. Results Our data indicate that ARE affects hepatocellular cancer via several pathways. AR offers a multi-faceted strategy to combating HCC by influencing critical metabolic pathways such α-linolenic acid and glycerophospholipid metabolism. Conclusions This research sheds new light on Artemisia rupestris L.‘s anticancer potential, setting the platform for a more in-depth knowledge of its influence on hepatocellular carcinoma using a multi-omics approach.https://doi.org/10.1007/s12672-025-03159-xFlavonoidsHepatocellular carcinomaMicrobiome |
| spellingShingle | Lina You WuKui Huang ShuYing Chen Unveiling the anticancer potential of flavonoids in hepatocellular carcinoma through microbiome and spatially resolved metabolomics analysis Discover Oncology Flavonoids Hepatocellular carcinoma Microbiome |
| title | Unveiling the anticancer potential of flavonoids in hepatocellular carcinoma through microbiome and spatially resolved metabolomics analysis |
| title_full | Unveiling the anticancer potential of flavonoids in hepatocellular carcinoma through microbiome and spatially resolved metabolomics analysis |
| title_fullStr | Unveiling the anticancer potential of flavonoids in hepatocellular carcinoma through microbiome and spatially resolved metabolomics analysis |
| title_full_unstemmed | Unveiling the anticancer potential of flavonoids in hepatocellular carcinoma through microbiome and spatially resolved metabolomics analysis |
| title_short | Unveiling the anticancer potential of flavonoids in hepatocellular carcinoma through microbiome and spatially resolved metabolomics analysis |
| title_sort | unveiling the anticancer potential of flavonoids in hepatocellular carcinoma through microbiome and spatially resolved metabolomics analysis |
| topic | Flavonoids Hepatocellular carcinoma Microbiome |
| url | https://doi.org/10.1007/s12672-025-03159-x |
| work_keys_str_mv | AT linayou unveilingtheanticancerpotentialofflavonoidsinhepatocellularcarcinomathroughmicrobiomeandspatiallyresolvedmetabolomicsanalysis AT wukuihuang unveilingtheanticancerpotentialofflavonoidsinhepatocellularcarcinomathroughmicrobiomeandspatiallyresolvedmetabolomicsanalysis AT shuyingchen unveilingtheanticancerpotentialofflavonoidsinhepatocellularcarcinomathroughmicrobiomeandspatiallyresolvedmetabolomicsanalysis |