Levodopa and pramipexole combination therapy efficacy in Vietnamese patients with Parkinson’s disease: a randomized controlled trial
Early diagnosis and appropriate treatment of Parkinson's disease to minimize the adverse effects of the disease and drug side effects on the patient. Using levodopa combined with pramipexole is an effective therapy for treating Parkinson's disease. Objectives — This study aims to evaluate...
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| Format: | Article |
| Language: | English |
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Limited liability company «Science and Innovations» (Saratov)
2024-03-01
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| Series: | Russian Open Medical Journal |
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| Online Access: | https://romj.org/node/552 |
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| author | Minh Van Le Dat Tien Diep Tam Thai Thanh Tran Tho Kieu Anh Pham Bao Lam Thai Tran Thang Nguyen |
| author_facet | Minh Van Le Dat Tien Diep Tam Thai Thanh Tran Tho Kieu Anh Pham Bao Lam Thai Tran Thang Nguyen |
| author_sort | Minh Van Le |
| collection | DOAJ |
| description | Early diagnosis and appropriate treatment of Parkinson's disease to minimize the adverse effects of the disease and drug side effects on the patient. Using levodopa combined with pramipexole is an effective therapy for treating Parkinson's disease.
Objectives — This study aims to evaluate the treatment outcome of combination therapy with levodopa and pramipexole compared to levodopa monotherapy in Vietnamese Parkinson's patients.
Material and Methods — A randomized controlled clinical trial with a 1:1 randomized ratio of 80 individuals with Parkinson's disease. The intervention group received a combination therapy with levodopa/benserazide and pramipexole, and the control group received a monotherapy with levodopa/benserazide. Motor symptoms, non-motor symptoms, The Unified Parkinson's Disease Rating (UPDRS), and The Parkinson's Disease Questionnaire (PDQ-39) scores were assessed before, after, and a follow-up period of 1 and 4 weeks after discharge to evaluate the treatment outcome.
Results — Combining therapy with levodopa and pramipexole led to statistically significant improvements in UPDRS and PDQ-39 scores (p<0.05). The mean difference in UPDRS parts I, II, and III after 4 weeks of discharge was -0.5 (p=0.014), -1.68 (p=0.005), and -2.52 (p=0.010) respectively. The quality of life was also enhanced by combining therapy due to a better reduction of PDQ-39 score: 26.0±6.3 versus 32.7±6.4 (p<0.001). The most common side effects were headache, nausea/vomiting, and somnolence.
Conclusions — Treatment with levodopa combined with pramipexole improves clinical symptoms and quality of life in patients with Parkinson's, as evidenced by improvements in UPDRS and PDQ-39 scores. |
| format | Article |
| id | doaj-art-29a5b07e028a4bafaa6b36b5f61348b6 |
| institution | DOAJ |
| issn | 2304-3415 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Limited liability company «Science and Innovations» (Saratov) |
| record_format | Article |
| series | Russian Open Medical Journal |
| spelling | doaj-art-29a5b07e028a4bafaa6b36b5f61348b62025-08-20T03:07:38ZengLimited liability company «Science and Innovations» (Saratov)Russian Open Medical Journal2304-34152024-03-01131e010710.15275/rusomj.2024.0107Levodopa and pramipexole combination therapy efficacy in Vietnamese patients with Parkinson’s disease: a randomized controlled trialMinh Van LeDat Tien DiepTam Thai Thanh TranTho Kieu Anh PhamBao Lam Thai TranThang NguyenEarly diagnosis and appropriate treatment of Parkinson's disease to minimize the adverse effects of the disease and drug side effects on the patient. Using levodopa combined with pramipexole is an effective therapy for treating Parkinson's disease. Objectives — This study aims to evaluate the treatment outcome of combination therapy with levodopa and pramipexole compared to levodopa monotherapy in Vietnamese Parkinson's patients. Material and Methods — A randomized controlled clinical trial with a 1:1 randomized ratio of 80 individuals with Parkinson's disease. The intervention group received a combination therapy with levodopa/benserazide and pramipexole, and the control group received a monotherapy with levodopa/benserazide. Motor symptoms, non-motor symptoms, The Unified Parkinson's Disease Rating (UPDRS), and The Parkinson's Disease Questionnaire (PDQ-39) scores were assessed before, after, and a follow-up period of 1 and 4 weeks after discharge to evaluate the treatment outcome. Results — Combining therapy with levodopa and pramipexole led to statistically significant improvements in UPDRS and PDQ-39 scores (p<0.05). The mean difference in UPDRS parts I, II, and III after 4 weeks of discharge was -0.5 (p=0.014), -1.68 (p=0.005), and -2.52 (p=0.010) respectively. The quality of life was also enhanced by combining therapy due to a better reduction of PDQ-39 score: 26.0±6.3 versus 32.7±6.4 (p<0.001). The most common side effects were headache, nausea/vomiting, and somnolence. Conclusions — Treatment with levodopa combined with pramipexole improves clinical symptoms and quality of life in patients with Parkinson's, as evidenced by improvements in UPDRS and PDQ-39 scores.https://romj.org/node/552parkinson's diseaselevodopapramipexolethe unified parkinson's disease ratingthe parkinson's disease questionnairerandomized controlled clinical trial |
| spellingShingle | Minh Van Le Dat Tien Diep Tam Thai Thanh Tran Tho Kieu Anh Pham Bao Lam Thai Tran Thang Nguyen Levodopa and pramipexole combination therapy efficacy in Vietnamese patients with Parkinson’s disease: a randomized controlled trial Russian Open Medical Journal parkinson's disease levodopa pramipexole the unified parkinson's disease rating the parkinson's disease questionnaire randomized controlled clinical trial |
| title | Levodopa and pramipexole combination therapy efficacy in Vietnamese patients with Parkinson’s disease: a randomized controlled trial |
| title_full | Levodopa and pramipexole combination therapy efficacy in Vietnamese patients with Parkinson’s disease: a randomized controlled trial |
| title_fullStr | Levodopa and pramipexole combination therapy efficacy in Vietnamese patients with Parkinson’s disease: a randomized controlled trial |
| title_full_unstemmed | Levodopa and pramipexole combination therapy efficacy in Vietnamese patients with Parkinson’s disease: a randomized controlled trial |
| title_short | Levodopa and pramipexole combination therapy efficacy in Vietnamese patients with Parkinson’s disease: a randomized controlled trial |
| title_sort | levodopa and pramipexole combination therapy efficacy in vietnamese patients with parkinson s disease a randomized controlled trial |
| topic | parkinson's disease levodopa pramipexole the unified parkinson's disease rating the parkinson's disease questionnaire randomized controlled clinical trial |
| url | https://romj.org/node/552 |
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