Cardiac Tissue Engineering Using Stimuli‐Responsive Biomaterials for the Targeted Therapy of Myocardial Infarction
ABSTRACT Cardiac tissue engineering presents a viable strategy for the targeted therapy of myocardial infarction (MI), overcoming the limitations of existing therapies in cardiac repair and regeneration. This review explores the potential of stimuli‐responsive biomaterials that engage with the cardi...
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| Format: | Article |
| Language: | English |
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Wiley
2025-03-01
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| Series: | MedComm – Biomaterials and Applications |
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| Online Access: | https://doi.org/10.1002/mba2.70009 |
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| author | Zarin Tasnim Tisha Kazi Tasnuva Alam Tanvir Ahmed |
| author_facet | Zarin Tasnim Tisha Kazi Tasnuva Alam Tanvir Ahmed |
| author_sort | Zarin Tasnim Tisha |
| collection | DOAJ |
| description | ABSTRACT Cardiac tissue engineering presents a viable strategy for the targeted therapy of myocardial infarction (MI), overcoming the limitations of existing therapies in cardiac repair and regeneration. This review explores the potential of stimuli‐responsive biomaterials that engage with the cardiac environment by reacting to various environmental stimuli including pH, temperature, enzymes, ultrasound, and reactive oxygen species. These materials enable precise drug delivery, modulate cellular responses, and enhance tissue regeneration. Biomaterials such as hydrogels, polymers, chitosan, collagen, and alginate improve the accuracy and effectiveness of targeted and localized delivery of drugs, stem cells, and growth factors, thus improving the precision and efficacy of treatments. The review looks at the ability of these biomaterials to mimic the complex biochemical and mechanical cues of a healthy myocardium. The challenges and prospects of clinical applications for stimuli‐responsive biomaterials are discussed, highlighting their transformative potential in targeted cardiac therapy while improving outcomes for patients with MI. |
| format | Article |
| id | doaj-art-29a4f0f97e684ebdb96cc7903c4f045c |
| institution | Kabale University |
| issn | 2769-643X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm – Biomaterials and Applications |
| spelling | doaj-art-29a4f0f97e684ebdb96cc7903c4f045c2025-08-20T03:42:40ZengWileyMedComm – Biomaterials and Applications2769-643X2025-03-0141n/an/a10.1002/mba2.70009Cardiac Tissue Engineering Using Stimuli‐Responsive Biomaterials for the Targeted Therapy of Myocardial InfarctionZarin Tasnim Tisha0Kazi Tasnuva Alam1Tanvir Ahmed2School of Pharmacy Brac University Dhaka BangladeshDepartment of Pharmaceutical Sciences, School of Health and Life Sciences North South University Dhaka BangladeshDepartment of Pharmaceutical Sciences, School of Health and Life Sciences North South University Dhaka BangladeshABSTRACT Cardiac tissue engineering presents a viable strategy for the targeted therapy of myocardial infarction (MI), overcoming the limitations of existing therapies in cardiac repair and regeneration. This review explores the potential of stimuli‐responsive biomaterials that engage with the cardiac environment by reacting to various environmental stimuli including pH, temperature, enzymes, ultrasound, and reactive oxygen species. These materials enable precise drug delivery, modulate cellular responses, and enhance tissue regeneration. Biomaterials such as hydrogels, polymers, chitosan, collagen, and alginate improve the accuracy and effectiveness of targeted and localized delivery of drugs, stem cells, and growth factors, thus improving the precision and efficacy of treatments. The review looks at the ability of these biomaterials to mimic the complex biochemical and mechanical cues of a healthy myocardium. The challenges and prospects of clinical applications for stimuli‐responsive biomaterials are discussed, highlighting their transformative potential in targeted cardiac therapy while improving outcomes for patients with MI.https://doi.org/10.1002/mba2.70009cardiac tissue engineeringcardiomyocytesmyocardial infarctionstimuli‐responsive biomaterials |
| spellingShingle | Zarin Tasnim Tisha Kazi Tasnuva Alam Tanvir Ahmed Cardiac Tissue Engineering Using Stimuli‐Responsive Biomaterials for the Targeted Therapy of Myocardial Infarction MedComm – Biomaterials and Applications cardiac tissue engineering cardiomyocytes myocardial infarction stimuli‐responsive biomaterials |
| title | Cardiac Tissue Engineering Using Stimuli‐Responsive Biomaterials for the Targeted Therapy of Myocardial Infarction |
| title_full | Cardiac Tissue Engineering Using Stimuli‐Responsive Biomaterials for the Targeted Therapy of Myocardial Infarction |
| title_fullStr | Cardiac Tissue Engineering Using Stimuli‐Responsive Biomaterials for the Targeted Therapy of Myocardial Infarction |
| title_full_unstemmed | Cardiac Tissue Engineering Using Stimuli‐Responsive Biomaterials for the Targeted Therapy of Myocardial Infarction |
| title_short | Cardiac Tissue Engineering Using Stimuli‐Responsive Biomaterials for the Targeted Therapy of Myocardial Infarction |
| title_sort | cardiac tissue engineering using stimuli responsive biomaterials for the targeted therapy of myocardial infarction |
| topic | cardiac tissue engineering cardiomyocytes myocardial infarction stimuli‐responsive biomaterials |
| url | https://doi.org/10.1002/mba2.70009 |
| work_keys_str_mv | AT zarintasnimtisha cardiactissueengineeringusingstimuliresponsivebiomaterialsforthetargetedtherapyofmyocardialinfarction AT kazitasnuvaalam cardiactissueengineeringusingstimuliresponsivebiomaterialsforthetargetedtherapyofmyocardialinfarction AT tanvirahmed cardiactissueengineeringusingstimuliresponsivebiomaterialsforthetargetedtherapyofmyocardialinfarction |