Microglia in the aged brain develop a hypoactive molecular phenotype after surgery

Microglia in the aged brain develop a hypoactive molecular phenotype after surgery

Abstract Background Microglia, the resident immune cells of the brain, play a crucial role in maintaining homeostasis in the central nervous system (CNS). However, they can also contribute to neurodegeneration through their pro-inflammatory properties and phagocytic functions. Acute post-operative c...

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Bibliographic Details
Main Authors: Zhuoran Yin, Anna K. Leonard, Carl M. Porto, Zhongcong Xie, Sebastian Silveira, Deborah J. Culley, Oleg Butovsky, Gregory Crosby
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Aging
Surgery
Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-024-03307-0
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