Comparative Effects of Vitamin D Supplementation on Oxidative Stress in Relapsing–Remitting Multiple Sclerosis
Studies suggest that vitamin D (VitD) may reduce oxidative stress (OS) in multiple sclerosis (MS) patients. This study aimed to compare the effects of various VitD doses on OS in relapsing–remitting MS (RRMS). A 6-month supplementation was introduced using two doses of VitD: 2000 IU/day in the high-...
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2024-12-01
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| author | Martyna Lis Natalia Niedziela Jowita Adamczyk-Zostawa Jolanta Zalejska-Fiolka Jarosław Szczygieł Agata Sowa Agata Świętek Monika Adamczyk-Sowa |
| author_facet | Martyna Lis Natalia Niedziela Jowita Adamczyk-Zostawa Jolanta Zalejska-Fiolka Jarosław Szczygieł Agata Sowa Agata Świętek Monika Adamczyk-Sowa |
| author_sort | Martyna Lis |
| collection | DOAJ |
| description | Studies suggest that vitamin D (VitD) may reduce oxidative stress (OS) in multiple sclerosis (MS) patients. This study aimed to compare the effects of various VitD doses on OS in relapsing–remitting MS (RRMS). A 6-month supplementation was introduced using two doses of VitD: 2000 IU/day in the high-dose group (HD, <i>n</i> = 23) and 15,960 IU/month in the low-dose group (LD, <i>n</i> = 29). Significant differences in body weight, height, and age were found between groups. A significant increase in the level of VitD (25(OH)D) was noted in both groups (<i>p</i> < 0.01). A significant increase was observed in the levels of LF and MDA (<i>p</i> < 0.01) and a significant decrease in the concentrations of PSH (<i>p</i> < 0.01), CuZnSOD (<i>p</i> = 0.02), and TOS (<i>p</i> < 0.01). A significant positive correlation was observed between serum VitD and SOD (R = 0.38, <i>p</i> < 0.01) and MnSOD (R = 0.31, <i>p</i> < 0.05), as well as a significant negative correlation between serum VitD and MDA (R = −0.31, <i>p</i> = 0.05) at the beginning of the study. At the end of the study, a significant positive correlation was observed between serum VitD and SOD (R = 0.34, <i>p</i> < 0.05) and CuZnSOD (R = 0.51, <i>p</i> < 0.01). In RRMS patients, the VitD doses are probably insufficient to induce a beneficial effect on the pro- and antioxidant balance. |
| format | Article |
| id | doaj-art-299d15e9bba94ae0bd67e9bbda9f890e |
| institution | DOAJ |
| issn | 1467-3037 1467-3045 |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-299d15e9bba94ae0bd67e9bbda9f890e2025-08-20T02:55:36ZengMDPI AGCurrent Issues in Molecular Biology1467-30371467-30452024-12-014612141191413110.3390/cimb46120845Comparative Effects of Vitamin D Supplementation on Oxidative Stress in Relapsing–Remitting Multiple SclerosisMartyna Lis0Natalia Niedziela1Jowita Adamczyk-Zostawa2Jolanta Zalejska-Fiolka3Jarosław Szczygieł4Agata Sowa5Agata Świętek6Monika Adamczyk-Sowa7Department of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandDepartment of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandDepartment of Ophthalmology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandDepartment of Biochemistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandDepartment of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandDepartment of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandSilesia LabMed Research and Implementation Center, Medical University of Silesia in Katowice, 41-808 Zabrze, PolandDepartment of Neurology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, PolandStudies suggest that vitamin D (VitD) may reduce oxidative stress (OS) in multiple sclerosis (MS) patients. This study aimed to compare the effects of various VitD doses on OS in relapsing–remitting MS (RRMS). A 6-month supplementation was introduced using two doses of VitD: 2000 IU/day in the high-dose group (HD, <i>n</i> = 23) and 15,960 IU/month in the low-dose group (LD, <i>n</i> = 29). Significant differences in body weight, height, and age were found between groups. A significant increase in the level of VitD (25(OH)D) was noted in both groups (<i>p</i> < 0.01). A significant increase was observed in the levels of LF and MDA (<i>p</i> < 0.01) and a significant decrease in the concentrations of PSH (<i>p</i> < 0.01), CuZnSOD (<i>p</i> = 0.02), and TOS (<i>p</i> < 0.01). A significant positive correlation was observed between serum VitD and SOD (R = 0.38, <i>p</i> < 0.01) and MnSOD (R = 0.31, <i>p</i> < 0.05), as well as a significant negative correlation between serum VitD and MDA (R = −0.31, <i>p</i> = 0.05) at the beginning of the study. At the end of the study, a significant positive correlation was observed between serum VitD and SOD (R = 0.34, <i>p</i> < 0.05) and CuZnSOD (R = 0.51, <i>p</i> < 0.01). In RRMS patients, the VitD doses are probably insufficient to induce a beneficial effect on the pro- and antioxidant balance.https://www.mdpi.com/1467-3045/46/12/845multiple sclerosisoxidative stress25(OH)Dvitamin D supplementationantioxidants |
| spellingShingle | Martyna Lis Natalia Niedziela Jowita Adamczyk-Zostawa Jolanta Zalejska-Fiolka Jarosław Szczygieł Agata Sowa Agata Świętek Monika Adamczyk-Sowa Comparative Effects of Vitamin D Supplementation on Oxidative Stress in Relapsing–Remitting Multiple Sclerosis Current Issues in Molecular Biology multiple sclerosis oxidative stress 25(OH)D vitamin D supplementation antioxidants |
| title | Comparative Effects of Vitamin D Supplementation on Oxidative Stress in Relapsing–Remitting Multiple Sclerosis |
| title_full | Comparative Effects of Vitamin D Supplementation on Oxidative Stress in Relapsing–Remitting Multiple Sclerosis |
| title_fullStr | Comparative Effects of Vitamin D Supplementation on Oxidative Stress in Relapsing–Remitting Multiple Sclerosis |
| title_full_unstemmed | Comparative Effects of Vitamin D Supplementation on Oxidative Stress in Relapsing–Remitting Multiple Sclerosis |
| title_short | Comparative Effects of Vitamin D Supplementation on Oxidative Stress in Relapsing–Remitting Multiple Sclerosis |
| title_sort | comparative effects of vitamin d supplementation on oxidative stress in relapsing remitting multiple sclerosis |
| topic | multiple sclerosis oxidative stress 25(OH)D vitamin D supplementation antioxidants |
| url | https://www.mdpi.com/1467-3045/46/12/845 |
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