Antimicrobial Resistance and Genomic Characterization of Salmonella Serovars Typhimurium and 4,[5],12:i:- in Huzhou, China
Wei Yan, Lei Ji, Yunfeng Zha, Fenfen Dong, Deshun Xu Huzhou Center for Disease Control and Prevention, Huzhou, 313000, People’s Republic of ChinaCorrespondence: Deshun Xu, Huzhou Center for Disease Control and Prevention, 999 Changxing Road, Huzhou, Zhejiang, 313000, People’s Republic of China, Emai...
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Dove Medical Press
2025-05-01
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| Series: | Infection and Drug Resistance |
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| Online Access: | https://www.dovepress.com/antimicrobial-resistance-and-genomic-characterization-of-salmonella-se-peer-reviewed-fulltext-article-IDR |
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| author | Yan W Ji L Zha Y Dong F Xu D |
| author_facet | Yan W Ji L Zha Y Dong F Xu D |
| author_sort | Yan W |
| collection | DOAJ |
| description | Wei Yan, Lei Ji, Yunfeng Zha, Fenfen Dong, Deshun Xu Huzhou Center for Disease Control and Prevention, Huzhou, 313000, People’s Republic of ChinaCorrespondence: Deshun Xu, Huzhou Center for Disease Control and Prevention, 999 Changxing Road, Huzhou, Zhejiang, 313000, People’s Republic of China, Email xds666092@126.comObjective: Salmonella serovar Typhimurium (S. Typhimurium) and its monophasic variant, Salmonella 4,[5],12:i:-, have become two of the most frequently isolated serovars worldwide, in both humans and animals. This study investigated the antimicrobial resistance and genomic characteristics of these two serovar Salmonella.Methods: Between 2021 and 2023, a total of 90 S. Typhimurium and Salmonella 4,[5],12:i:-were collected from clinical and food samples in Huzhou. Their antimicrobial resistance phenotype and genes, virulence genes, and phylogenetic relationship were analyzed.Results: Salmonella 4,[5],12:i:-, which all belong to ST34, has become the main serotype of Salmonella isolated in Huzhou instead of S. Typhimurium. Notably, we observed a higher incidence of infections among the young population (< 5 years old). The 90 Salmonella isolates were mainly resistant to tetracycline (94.4%), ampicillin (72.2%), and trimethoprim/sulfamethoxazole (70.0%), with multidrug resistance (MDR) rates as high as 93.3%. Genome sequencing indicated that these isolates possessed 39 antimicrobial resistance genes and 184 virulence genes.Conclusion: This research enhances our understanding of S. Typhimurium and Salmonella 4,[5],12:i:- infections, which is helpful to guide clinical responses.Keywords: Salmonella typhimurium, monophasic variant, antimicrobial resistance, multidrug resistance, whole genome sequencing |
| format | Article |
| id | doaj-art-299cff0897524facbc47a7025df8ddc9 |
| institution | Kabale University |
| issn | 1178-6973 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Infection and Drug Resistance |
| spelling | doaj-art-299cff0897524facbc47a7025df8ddc92025-08-20T03:29:49ZengDove Medical PressInfection and Drug Resistance1178-69732025-05-01Volume 18Issue 127652777103463Antimicrobial Resistance and Genomic Characterization of Salmonella Serovars Typhimurium and 4,[5],12:i:- in Huzhou, ChinaYan W0Ji L1Zha YDong FXu DLabThe Microbiology Laboratory DepartmentWei Yan, Lei Ji, Yunfeng Zha, Fenfen Dong, Deshun Xu Huzhou Center for Disease Control and Prevention, Huzhou, 313000, People’s Republic of ChinaCorrespondence: Deshun Xu, Huzhou Center for Disease Control and Prevention, 999 Changxing Road, Huzhou, Zhejiang, 313000, People’s Republic of China, Email xds666092@126.comObjective: Salmonella serovar Typhimurium (S. Typhimurium) and its monophasic variant, Salmonella 4,[5],12:i:-, have become two of the most frequently isolated serovars worldwide, in both humans and animals. This study investigated the antimicrobial resistance and genomic characteristics of these two serovar Salmonella.Methods: Between 2021 and 2023, a total of 90 S. Typhimurium and Salmonella 4,[5],12:i:-were collected from clinical and food samples in Huzhou. Their antimicrobial resistance phenotype and genes, virulence genes, and phylogenetic relationship were analyzed.Results: Salmonella 4,[5],12:i:-, which all belong to ST34, has become the main serotype of Salmonella isolated in Huzhou instead of S. Typhimurium. Notably, we observed a higher incidence of infections among the young population (< 5 years old). The 90 Salmonella isolates were mainly resistant to tetracycline (94.4%), ampicillin (72.2%), and trimethoprim/sulfamethoxazole (70.0%), with multidrug resistance (MDR) rates as high as 93.3%. Genome sequencing indicated that these isolates possessed 39 antimicrobial resistance genes and 184 virulence genes.Conclusion: This research enhances our understanding of S. Typhimurium and Salmonella 4,[5],12:i:- infections, which is helpful to guide clinical responses.Keywords: Salmonella typhimurium, monophasic variant, antimicrobial resistance, multidrug resistance, whole genome sequencinghttps://www.dovepress.com/antimicrobial-resistance-and-genomic-characterization-of-salmonella-se-peer-reviewed-fulltext-article-IDRSalmonella Typhimurium;monophasicvariant;antimicrobial resistance;multidrug resistance;whole genome sequencing |
| spellingShingle | Yan W Ji L Zha Y Dong F Xu D Antimicrobial Resistance and Genomic Characterization of Salmonella Serovars Typhimurium and 4,[5],12:i:- in Huzhou, China Infection and Drug Resistance Salmonella Typhimurium;monophasicvariant;antimicrobial resistance;multidrug resistance;whole genome sequencing |
| title | Antimicrobial Resistance and Genomic Characterization of Salmonella Serovars Typhimurium and 4,[5],12:i:- in Huzhou, China |
| title_full | Antimicrobial Resistance and Genomic Characterization of Salmonella Serovars Typhimurium and 4,[5],12:i:- in Huzhou, China |
| title_fullStr | Antimicrobial Resistance and Genomic Characterization of Salmonella Serovars Typhimurium and 4,[5],12:i:- in Huzhou, China |
| title_full_unstemmed | Antimicrobial Resistance and Genomic Characterization of Salmonella Serovars Typhimurium and 4,[5],12:i:- in Huzhou, China |
| title_short | Antimicrobial Resistance and Genomic Characterization of Salmonella Serovars Typhimurium and 4,[5],12:i:- in Huzhou, China |
| title_sort | antimicrobial resistance and genomic characterization of salmonella serovars typhimurium and 4 5 12 i in huzhou china |
| topic | Salmonella Typhimurium;monophasicvariant;antimicrobial resistance;multidrug resistance;whole genome sequencing |
| url | https://www.dovepress.com/antimicrobial-resistance-and-genomic-characterization-of-salmonella-se-peer-reviewed-fulltext-article-IDR |
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