THE RANDOMIZED STUDY OF EFFICIENCY OF PREOPERATIVE PHOTODYNAMIC
The authors made a prospective randomized comparison of results of preoperative photodynamic therapy (PhT) with chemotherapy, preoperative chemotherapy in initial unresectable central non-small cell lung cancer in stage III. The efficiency and safety of preoperative therapy were estimated as well as...
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| Language: | Russian |
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Pavlov First Saint Petersburg State Medical University
2018-01-01
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| Series: | Вестник хирургии имени И.И. Грекова |
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| Online Access: | https://www.vestnik-grekova.ru/jour/article/view/755 |
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| author | A. L. Akopov A. A. Rusanov V. P. Molodtsova A. V. Gerasin N. V. Kazakov M. A. Urtenova I. V. Chistyakov |
| author_facet | A. L. Akopov A. A. Rusanov V. P. Molodtsova A. V. Gerasin N. V. Kazakov M. A. Urtenova I. V. Chistyakov |
| author_sort | A. L. Akopov |
| collection | DOAJ |
| description | The authors made a prospective randomized comparison of results of preoperative photodynamic therapy (PhT) with chemotherapy, preoperative chemotherapy in initial unresectable central non-small cell lung cancer in stage III. The efficiency and safety of preoperative therapy were estimated as well as the possibility of subsequent surgical treatment. The research included patients in stage IIIA and IIIB of central non-small cell lung cancer with lesions of primary bronchi and lower section of the trachea, which initially were unresectable, but potentially the patients could be operated on after preoperative treatment. The photodynamic therapy was performed using chlorine E6 and the light of wave length 662 nm. Since January 2008 till December 2011, 42 patients were included in the research, 21 patients were randomized in the group for photodynamic therapy and 21 — in group without PhT. These groups were compared according to their sex, age, stage of the disease and histological findings. After nonadjuvant treatment the remissions were reached in 19 (90%) patients of the group with PhT and in 16 (76%) patients without PhT and all the patients were operated on. The explorative operations were made on 3 patients out of 16 operated on in the group without PhT (19%). In the group PhT 14 pneumonectomies and 5 lobectomies were perfomed opposite 10 pneumonectomies and 3 lobectomies in group without PhT. The degree of radicalism of resection appears to be reliably higher in the group PhT (RO– 89%, R1–11% as against RO–54%, R1–46% in group without PhT), p=0,038. The preoperative endobronchial PhT conducted with chemotherapy was characterized by efficiency and safety, allowed the surgical treatment and elevated the degree of radicalism of this treatment in selected patients, initially assessed as unresectable. |
| format | Article |
| id | doaj-art-299ccb04b15e46fbbcbe56cef1614076 |
| institution | DOAJ |
| issn | 0042-4625 |
| language | Russian |
| publishDate | 2018-01-01 |
| publisher | Pavlov First Saint Petersburg State Medical University |
| record_format | Article |
| series | Вестник хирургии имени И.И. Грекова |
| spelling | doaj-art-299ccb04b15e46fbbcbe56cef16140762025-08-20T03:02:11ZrusPavlov First Saint Petersburg State Medical UniversityВестник хирургии имени И.И. Грекова0042-46252018-01-01172102002410.24884/0042-4625-2013-172-1-020-024754THE RANDOMIZED STUDY OF EFFICIENCY OF PREOPERATIVE PHOTODYNAMICA. L. Akopov0A. A. Rusanov1V. P. Molodtsova2A. V. Gerasin3N. V. Kazakov4M. A. Urtenova5I. V. Chistyakov6State Pavlov Medical UniversityState Pavlov Medical UniversityState Pavlov Medical UniversityState Pavlov Medical UniversityState Pavlov Medical UniversityState Pavlov Medical UniversityState Pavlov Medical UniversityThe authors made a prospective randomized comparison of results of preoperative photodynamic therapy (PhT) with chemotherapy, preoperative chemotherapy in initial unresectable central non-small cell lung cancer in stage III. The efficiency and safety of preoperative therapy were estimated as well as the possibility of subsequent surgical treatment. The research included patients in stage IIIA and IIIB of central non-small cell lung cancer with lesions of primary bronchi and lower section of the trachea, which initially were unresectable, but potentially the patients could be operated on after preoperative treatment. The photodynamic therapy was performed using chlorine E6 and the light of wave length 662 nm. Since January 2008 till December 2011, 42 patients were included in the research, 21 patients were randomized in the group for photodynamic therapy and 21 — in group without PhT. These groups were compared according to their sex, age, stage of the disease and histological findings. After nonadjuvant treatment the remissions were reached in 19 (90%) patients of the group with PhT and in 16 (76%) patients without PhT and all the patients were operated on. The explorative operations were made on 3 patients out of 16 operated on in the group without PhT (19%). In the group PhT 14 pneumonectomies and 5 lobectomies were perfomed opposite 10 pneumonectomies and 3 lobectomies in group without PhT. The degree of radicalism of resection appears to be reliably higher in the group PhT (RO– 89%, R1–11% as against RO–54%, R1–46% in group without PhT), p=0,038. The preoperative endobronchial PhT conducted with chemotherapy was characterized by efficiency and safety, allowed the surgical treatment and elevated the degree of radicalism of this treatment in selected patients, initially assessed as unresectable.https://www.vestnik-grekova.ru/jour/article/view/755фотодинамическая терапияэндобронхиальнаянеоадьювантнаяхимиотерапиянемелкоклеточный рак лёгкогоphotodynamic therapyendobronchicalnon-adjuvant chemotherapynon-small cell lung cancer |
| spellingShingle | A. L. Akopov A. A. Rusanov V. P. Molodtsova A. V. Gerasin N. V. Kazakov M. A. Urtenova I. V. Chistyakov THE RANDOMIZED STUDY OF EFFICIENCY OF PREOPERATIVE PHOTODYNAMIC Вестник хирургии имени И.И. Грекова фотодинамическая терапия эндобронхиальная неоадьювантная химиотерапия немелкоклеточный рак лёгкого photodynamic therapy endobronchical non-adjuvant chemotherapy non-small cell lung cancer |
| title | THE RANDOMIZED STUDY OF EFFICIENCY OF PREOPERATIVE PHOTODYNAMIC |
| title_full | THE RANDOMIZED STUDY OF EFFICIENCY OF PREOPERATIVE PHOTODYNAMIC |
| title_fullStr | THE RANDOMIZED STUDY OF EFFICIENCY OF PREOPERATIVE PHOTODYNAMIC |
| title_full_unstemmed | THE RANDOMIZED STUDY OF EFFICIENCY OF PREOPERATIVE PHOTODYNAMIC |
| title_short | THE RANDOMIZED STUDY OF EFFICIENCY OF PREOPERATIVE PHOTODYNAMIC |
| title_sort | randomized study of efficiency of preoperative photodynamic |
| topic | фотодинамическая терапия эндобронхиальная неоадьювантная химиотерапия немелкоклеточный рак лёгкого photodynamic therapy endobronchical non-adjuvant chemotherapy non-small cell lung cancer |
| url | https://www.vestnik-grekova.ru/jour/article/view/755 |
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