The history of haploidentical stem cell transplantation: a trip from the bench to the bedside
Allogeneic bone marrow transplantation is a curative intervention for both neoplastic and non-malignant conditions. However, not all patients have an HLA-matched donor. Therefore, the development of an approach that expand the donor pool was of paramount relevance. The development of post-transplant...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Hematology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2024.2346401 |
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| _version_ | 1846126633821405184 |
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| author | Mariana G. Meade Javier Bolaños-Meade |
| author_facet | Mariana G. Meade Javier Bolaños-Meade |
| author_sort | Mariana G. Meade |
| collection | DOAJ |
| description | Allogeneic bone marrow transplantation is a curative intervention for both neoplastic and non-malignant conditions. However, not all patients have an HLA-matched donor. Therefore, the development of an approach that expand the donor pool was of paramount relevance. The development of post-transplantation cyclophosphamide as graft versus host disease prophylaxis allows the safe use of haploidentical donors, solving the donor availability problem to the vast majority of patients in need. The present paper reviews the history of the development of haploidentical transplantation at Johns Hopkins University, from the bench to the bedside. |
| format | Article |
| id | doaj-art-299bcd33869948dc95e7bf48c65dd776 |
| institution | Kabale University |
| issn | 1607-8454 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hematology |
| spelling | doaj-art-299bcd33869948dc95e7bf48c65dd7762024-12-12T15:08:53ZengTaylor & Francis GroupHematology1607-84542024-12-0129110.1080/16078454.2024.2346401The history of haploidentical stem cell transplantation: a trip from the bench to the bedsideMariana G. Meade0Javier Bolaños-Meade1Research assistant, Johns Hopkins UniversityProfessor of Oncology, Johns Hopkins University School of Medicine, Clinical Director, BMT Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, USAAllogeneic bone marrow transplantation is a curative intervention for both neoplastic and non-malignant conditions. However, not all patients have an HLA-matched donor. Therefore, the development of an approach that expand the donor pool was of paramount relevance. The development of post-transplantation cyclophosphamide as graft versus host disease prophylaxis allows the safe use of haploidentical donors, solving the donor availability problem to the vast majority of patients in need. The present paper reviews the history of the development of haploidentical transplantation at Johns Hopkins University, from the bench to the bedside.https://www.tandfonline.com/doi/10.1080/16078454.2024.2346401HaploidenticalHLA-matchedbone marrow transplantationacute graft versus host diseasechronic graft versus host diseasegraft failure |
| spellingShingle | Mariana G. Meade Javier Bolaños-Meade The history of haploidentical stem cell transplantation: a trip from the bench to the bedside Hematology Haploidentical HLA-matched bone marrow transplantation acute graft versus host disease chronic graft versus host disease graft failure |
| title | The history of haploidentical stem cell transplantation: a trip from the bench to the bedside |
| title_full | The history of haploidentical stem cell transplantation: a trip from the bench to the bedside |
| title_fullStr | The history of haploidentical stem cell transplantation: a trip from the bench to the bedside |
| title_full_unstemmed | The history of haploidentical stem cell transplantation: a trip from the bench to the bedside |
| title_short | The history of haploidentical stem cell transplantation: a trip from the bench to the bedside |
| title_sort | history of haploidentical stem cell transplantation a trip from the bench to the bedside |
| topic | Haploidentical HLA-matched bone marrow transplantation acute graft versus host disease chronic graft versus host disease graft failure |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2024.2346401 |
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