Relationship between cognitive functions and serum neurotrophic factor levels in long-term hospitalized male patients with schizophrenia
Abstract Objective This study explored the changes in serum neurotrophic factor levels, the status of cognitive function, event-related potential P300, and the relationships between serum neurotrophic factor levels and cognitive functions, as well as event-related potential P300 in male schizophreni...
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2025-07-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-025-07173-9 |
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| author | Pan Jing Xiaopeng Yin Haihang Yu Ye Fu Fangmin Wang Xi Mei Qiaozhen Zhang Qing Tian Xiaobin Zhang |
| author_facet | Pan Jing Xiaopeng Yin Haihang Yu Ye Fu Fangmin Wang Xi Mei Qiaozhen Zhang Qing Tian Xiaobin Zhang |
| author_sort | Pan Jing |
| collection | DOAJ |
| description | Abstract Objective This study explored the changes in serum neurotrophic factor levels, the status of cognitive function, event-related potential P300, and the relationships between serum neurotrophic factor levels and cognitive functions, as well as event-related potential P300 in male schizophrenia patients with long-term hospitalization. Methods A total of 82 male schizophrenia patients with long-term hospitalization and 52 healthy controls were recruited. Cognitive functions were evaluated in all participants, including verbal fluency function, attention function, executive function, and spatial function. Event-related potential P300 latency and amplitude were recorded using the Nicolet Viking Quest evoked potential system (USA). The serum levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) were measured in all participants using enzyme-linked immunosorbent assay (ELISA). Results The patient group exhibited significantly poorer performance in all cognitive functions compared to the control group (p < 0.05). The patient group exhibited a statistically significant prolongation in P300 latency and a reduction in P300 amplitude compared to the control group (P < 0.01). In addition, serum BDNF levels were significantly lower in the patient group (9.1 ± 2.1 ng/ml) compared to the control group (11.6 ± 2.3 ng/ml, P < 0.01). Serum GDNF levels were 603.4 ± 182.6 pg/ml in the patient group and 610.2 ± 176.3 pg/ml in the control group, showing no statistically significant difference (P > 0.05). Onset levels were significantly correlated with almost all cognitive functions. BDNF levels were correlated to digital cancellation test scores (P < 0.05) and trail making test part B (TMT-part B) scores (P < 0.05). Moreover, a correlation was found between GDNF levels and block design test scores (P < 0.05). The latency of P300 was correlated to digital cancellation test scores (P < 0.01) and trail making test part A (TMT-part A) scores (P < 0.05). The amplitude of P300 was correlated with digital cancellation test scores (P < 0.01). Conclusions This study reveals that patients with chronic schizophrenia suffer from notable cognitive deficits during long-term hospitalization, which is linked to specific clinical characteristics. The patient group exhibited significantly lower serum BDNF levels than the control group. Event-related potential P300 testing revealed prolonged latency and reduced amplitude in patients. Serum BDNF and GDNF levels were selectively correlated with specific cognitive function performance. |
| format | Article |
| id | doaj-art-2999e4b8e6ca428a9df7e6a7fa9e4a9a |
| institution | Kabale University |
| issn | 1471-244X |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | BMC Psychiatry |
| spelling | doaj-art-2999e4b8e6ca428a9df7e6a7fa9e4a9a2025-08-20T03:43:29ZengBMCBMC Psychiatry1471-244X2025-07-0125111010.1186/s12888-025-07173-9Relationship between cognitive functions and serum neurotrophic factor levels in long-term hospitalized male patients with schizophreniaPan Jing0Xiaopeng Yin1Haihang Yu2Ye Fu3Fangmin Wang4Xi Mei5Qiaozhen Zhang6Qing Tian7Xiaobin Zhang8Department of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo Kangning HospitalDepartment of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo Kangning HospitalDepartment of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo Kangning HospitalIntensive Care Unit, The Affiliated People’s Hospital of Ningbo University, Yinzhou People’s HospitalDepartment of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo Kangning HospitalDepartment of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo Kangning HospitalDepartment of Psychiatry, The Affiliated Kangning Hospital of Ningbo University, Ningbo Kangning HospitalDepartment of Psychiatry, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow UniversityDepartment of Psychiatry, Suzhou Guangji Hospital, The Affiliated Guangji Hospital of Soochow UniversityAbstract Objective This study explored the changes in serum neurotrophic factor levels, the status of cognitive function, event-related potential P300, and the relationships between serum neurotrophic factor levels and cognitive functions, as well as event-related potential P300 in male schizophrenia patients with long-term hospitalization. Methods A total of 82 male schizophrenia patients with long-term hospitalization and 52 healthy controls were recruited. Cognitive functions were evaluated in all participants, including verbal fluency function, attention function, executive function, and spatial function. Event-related potential P300 latency and amplitude were recorded using the Nicolet Viking Quest evoked potential system (USA). The serum levels of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF) were measured in all participants using enzyme-linked immunosorbent assay (ELISA). Results The patient group exhibited significantly poorer performance in all cognitive functions compared to the control group (p < 0.05). The patient group exhibited a statistically significant prolongation in P300 latency and a reduction in P300 amplitude compared to the control group (P < 0.01). In addition, serum BDNF levels were significantly lower in the patient group (9.1 ± 2.1 ng/ml) compared to the control group (11.6 ± 2.3 ng/ml, P < 0.01). Serum GDNF levels were 603.4 ± 182.6 pg/ml in the patient group and 610.2 ± 176.3 pg/ml in the control group, showing no statistically significant difference (P > 0.05). Onset levels were significantly correlated with almost all cognitive functions. BDNF levels were correlated to digital cancellation test scores (P < 0.05) and trail making test part B (TMT-part B) scores (P < 0.05). Moreover, a correlation was found between GDNF levels and block design test scores (P < 0.05). The latency of P300 was correlated to digital cancellation test scores (P < 0.01) and trail making test part A (TMT-part A) scores (P < 0.05). The amplitude of P300 was correlated with digital cancellation test scores (P < 0.01). Conclusions This study reveals that patients with chronic schizophrenia suffer from notable cognitive deficits during long-term hospitalization, which is linked to specific clinical characteristics. The patient group exhibited significantly lower serum BDNF levels than the control group. Event-related potential P300 testing revealed prolonged latency and reduced amplitude in patients. Serum BDNF and GDNF levels were selectively correlated with specific cognitive function performance.https://doi.org/10.1186/s12888-025-07173-9SchizophreniaCognitive functionsNeurotrophic factorsEvent-related potentialsBDNFGDNF |
| spellingShingle | Pan Jing Xiaopeng Yin Haihang Yu Ye Fu Fangmin Wang Xi Mei Qiaozhen Zhang Qing Tian Xiaobin Zhang Relationship between cognitive functions and serum neurotrophic factor levels in long-term hospitalized male patients with schizophrenia BMC Psychiatry Schizophrenia Cognitive functions Neurotrophic factors Event-related potentials BDNF GDNF |
| title | Relationship between cognitive functions and serum neurotrophic factor levels in long-term hospitalized male patients with schizophrenia |
| title_full | Relationship between cognitive functions and serum neurotrophic factor levels in long-term hospitalized male patients with schizophrenia |
| title_fullStr | Relationship between cognitive functions and serum neurotrophic factor levels in long-term hospitalized male patients with schizophrenia |
| title_full_unstemmed | Relationship between cognitive functions and serum neurotrophic factor levels in long-term hospitalized male patients with schizophrenia |
| title_short | Relationship between cognitive functions and serum neurotrophic factor levels in long-term hospitalized male patients with schizophrenia |
| title_sort | relationship between cognitive functions and serum neurotrophic factor levels in long term hospitalized male patients with schizophrenia |
| topic | Schizophrenia Cognitive functions Neurotrophic factors Event-related potentials BDNF GDNF |
| url | https://doi.org/10.1186/s12888-025-07173-9 |
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