Prognostic value of type 2 diabetes mellitus and visfatin level in patients after coronary artery bypass grafting
Objective — Our study aimed to evaluate the prognostic value of type 2 diabetes mellitus (DM) and the level of visfatin in patients undergoing coronary artery bypass grafting (CABG). Methods — Our study included 103 patients with chronic heart failure and stable coronary artery disease. The clinica...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Limited liability company «Science and Innovations» (Saratov)
2023-06-01
|
| Series: | Russian Open Medical Journal |
| Subjects: | |
| Online Access: | https://romj.org/node/526 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849697141083078656 |
|---|---|
| author | Alla A. Garganeeva Elena A. Kuzheleva Olga V. Tukish Sergey L. Andreev Oksana N. Ogurkova Sergey V. Popov |
| author_facet | Alla A. Garganeeva Elena A. Kuzheleva Olga V. Tukish Sergey L. Andreev Oksana N. Ogurkova Sergey V. Popov |
| author_sort | Alla A. Garganeeva |
| collection | DOAJ |
| description | Objective — Our study aimed to evaluate the prognostic value of type 2 diabetes mellitus (DM) and the level of visfatin in patients undergoing coronary artery bypass grafting (CABG).
Methods — Our study included 103 patients with chronic heart failure and stable coronary artery disease. The clinical outcomes and adverse cardiovascular events were analyzed 12 months after the CABG.
Results — The patients were distributed between two groups: Group 1 (without registration of composite endpoints, n=71) and Group 2 (patients with the development of composite endpoints, n=32). In Group 1, 22.5% of patients were diagnosed with DM vs. 31.2% in Group 2 (p=0.346). Kaplan-Meier estimator demonstrated that patients with duration of DM over 5 years experienced significantly earlier and more frequent adverse cardiovascular events after CABG vs. patients without DM or with duration of DM less than 5 years. The visfatin level before CABG did not differ between the groups (p=0.416), whereas 10 days after CABG it was higher in Group 2. Correlation between the difference in visfatin levels before and after CABG and duration of type 2 DM was calculated (r=0.54, p=0.041).
Conclusion — In patients after CABG, the duration of DM had a negative impact on the development of cardiovascular events. With a duration of DM exceeding 5 years, the risk of adverse events increased significantly. An increase in visfatin level 10 days after CABG was associated with the duration of DM and the development of adverse cardiovascular events in patients. |
| format | Article |
| id | doaj-art-298a5a9d77ef46fa9ebfd82d4b84e6ec |
| institution | DOAJ |
| issn | 2304-3415 |
| language | English |
| publishDate | 2023-06-01 |
| publisher | Limited liability company «Science and Innovations» (Saratov) |
| record_format | Article |
| series | Russian Open Medical Journal |
| spelling | doaj-art-298a5a9d77ef46fa9ebfd82d4b84e6ec2025-08-20T03:19:17ZengLimited liability company «Science and Innovations» (Saratov)Russian Open Medical Journal2304-34152023-06-01122e020510.15275/rusomj.2023.0205Prognostic value of type 2 diabetes mellitus and visfatin level in patients after coronary artery bypass graftingAlla A. GarganeevaElena A. KuzhelevaOlga V. TukishSergey L. AndreevOksana N. OgurkovaSergey V. PopovObjective — Our study aimed to evaluate the prognostic value of type 2 diabetes mellitus (DM) and the level of visfatin in patients undergoing coronary artery bypass grafting (CABG). Methods — Our study included 103 patients with chronic heart failure and stable coronary artery disease. The clinical outcomes and adverse cardiovascular events were analyzed 12 months after the CABG. Results — The patients were distributed between two groups: Group 1 (without registration of composite endpoints, n=71) and Group 2 (patients with the development of composite endpoints, n=32). In Group 1, 22.5% of patients were diagnosed with DM vs. 31.2% in Group 2 (p=0.346). Kaplan-Meier estimator demonstrated that patients with duration of DM over 5 years experienced significantly earlier and more frequent adverse cardiovascular events after CABG vs. patients without DM or with duration of DM less than 5 years. The visfatin level before CABG did not differ between the groups (p=0.416), whereas 10 days after CABG it was higher in Group 2. Correlation between the difference in visfatin levels before and after CABG and duration of type 2 DM was calculated (r=0.54, p=0.041). Conclusion — In patients after CABG, the duration of DM had a negative impact on the development of cardiovascular events. With a duration of DM exceeding 5 years, the risk of adverse events increased significantly. An increase in visfatin level 10 days after CABG was associated with the duration of DM and the development of adverse cardiovascular events in patients.https://romj.org/node/526diabetes mellituscoronary artery diseaseheart failurecoronary artery bypass graftingvisfatin |
| spellingShingle | Alla A. Garganeeva Elena A. Kuzheleva Olga V. Tukish Sergey L. Andreev Oksana N. Ogurkova Sergey V. Popov Prognostic value of type 2 diabetes mellitus and visfatin level in patients after coronary artery bypass grafting Russian Open Medical Journal diabetes mellitus coronary artery disease heart failure coronary artery bypass grafting visfatin |
| title | Prognostic value of type 2 diabetes mellitus and visfatin level in patients after coronary artery bypass grafting |
| title_full | Prognostic value of type 2 diabetes mellitus and visfatin level in patients after coronary artery bypass grafting |
| title_fullStr | Prognostic value of type 2 diabetes mellitus and visfatin level in patients after coronary artery bypass grafting |
| title_full_unstemmed | Prognostic value of type 2 diabetes mellitus and visfatin level in patients after coronary artery bypass grafting |
| title_short | Prognostic value of type 2 diabetes mellitus and visfatin level in patients after coronary artery bypass grafting |
| title_sort | prognostic value of type 2 diabetes mellitus and visfatin level in patients after coronary artery bypass grafting |
| topic | diabetes mellitus coronary artery disease heart failure coronary artery bypass grafting visfatin |
| url | https://romj.org/node/526 |
| work_keys_str_mv | AT allaagarganeeva prognosticvalueoftype2diabetesmellitusandvisfatinlevelinpatientsaftercoronaryarterybypassgrafting AT elenaakuzheleva prognosticvalueoftype2diabetesmellitusandvisfatinlevelinpatientsaftercoronaryarterybypassgrafting AT olgavtukish prognosticvalueoftype2diabetesmellitusandvisfatinlevelinpatientsaftercoronaryarterybypassgrafting AT sergeylandreev prognosticvalueoftype2diabetesmellitusandvisfatinlevelinpatientsaftercoronaryarterybypassgrafting AT oksananogurkova prognosticvalueoftype2diabetesmellitusandvisfatinlevelinpatientsaftercoronaryarterybypassgrafting AT sergeyvpopov prognosticvalueoftype2diabetesmellitusandvisfatinlevelinpatientsaftercoronaryarterybypassgrafting |