Kidney Disease after Heart and Lung Transplantation
Chronic kidney disease (CKD) is not only common after lung and heart transplantation but also is associated with increased morbidity and mortality due to multiple pre-, peri- and post-transplant factors. While the exact incidence of CKD in this population is not well-defined, it seems to have gradua...
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| Format: | Article |
| Language: | English |
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Houston Methodist DeBakey Heart & Vascular Center
2022-09-01
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| Series: | Methodist DeBakey Cardiovascular Journal |
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| Online Access: | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1122 |
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| author | Carlos M. Zapata Hassan N. Ibrahim |
| author_facet | Carlos M. Zapata Hassan N. Ibrahim |
| author_sort | Carlos M. Zapata |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is not only common after lung and heart transplantation but also is associated with increased morbidity and mortality due to multiple pre-, peri- and post-transplant factors. While the exact incidence of CKD in this population is not well-defined, it seems to have gradually increased over the years as older recipients are more frequently considered. The increasing success of the procedure and expanding transplant candidate pool has allowed many with comorbid conditions to receive a transplant, which was considered prohibitive in the past. This review presents risk factors that have been linked to CKD as well as interventions that may help alleviate this serious problem. The impact of pretransplant renal function and the overexaggerated role of chronic nephrotoxicity of calcineurin inhibitors is discussed in detail. Until the exact pathophysiology of kidney disease is better understood, there is a dire need to expand the research agenda beyond observational studies. |
| format | Article |
| id | doaj-art-2988efce84914965a8aac26b93aaff0e |
| institution | OA Journals |
| issn | 1947-6108 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Houston Methodist DeBakey Heart & Vascular Center |
| record_format | Article |
| series | Methodist DeBakey Cardiovascular Journal |
| spelling | doaj-art-2988efce84914965a8aac26b93aaff0e2025-08-20T02:22:16ZengHouston Methodist DeBakey Heart & Vascular CenterMethodist DeBakey Cardiovascular Journal1947-61082022-09-01184344010.14797/mdcvj.1122392Kidney Disease after Heart and Lung TransplantationCarlos M. Zapata0https://orcid.org/0000-0002-0364-5117Hassan N. Ibrahim1https://orcid.org/0000-0002-1567-9592Division of Kidney Diseases, Hypertension and Transplantation, Houston Methodist Hospital, Houston, TexasDivision of Kidney Diseases, Hypertension & Transplantation, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TexasChronic kidney disease (CKD) is not only common after lung and heart transplantation but also is associated with increased morbidity and mortality due to multiple pre-, peri- and post-transplant factors. While the exact incidence of CKD in this population is not well-defined, it seems to have gradually increased over the years as older recipients are more frequently considered. The increasing success of the procedure and expanding transplant candidate pool has allowed many with comorbid conditions to receive a transplant, which was considered prohibitive in the past. This review presents risk factors that have been linked to CKD as well as interventions that may help alleviate this serious problem. The impact of pretransplant renal function and the overexaggerated role of chronic nephrotoxicity of calcineurin inhibitors is discussed in detail. Until the exact pathophysiology of kidney disease is better understood, there is a dire need to expand the research agenda beyond observational studies.https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1122kidney diseaseckdheart transplantationlung transplantakisolid organ transplantsimultaneous transplantpost-transplant ckd |
| spellingShingle | Carlos M. Zapata Hassan N. Ibrahim Kidney Disease after Heart and Lung Transplantation Methodist DeBakey Cardiovascular Journal kidney disease ckd heart transplantation lung transplant aki solid organ transplant simultaneous transplant post-transplant ckd |
| title | Kidney Disease after Heart and Lung Transplantation |
| title_full | Kidney Disease after Heart and Lung Transplantation |
| title_fullStr | Kidney Disease after Heart and Lung Transplantation |
| title_full_unstemmed | Kidney Disease after Heart and Lung Transplantation |
| title_short | Kidney Disease after Heart and Lung Transplantation |
| title_sort | kidney disease after heart and lung transplantation |
| topic | kidney disease ckd heart transplantation lung transplant aki solid organ transplant simultaneous transplant post-transplant ckd |
| url | https://account.journal.houstonmethodist.org/index.php/up-j-mdbcj/article/view/1122 |
| work_keys_str_mv | AT carlosmzapata kidneydiseaseafterheartandlungtransplantation AT hassannibrahim kidneydiseaseafterheartandlungtransplantation |