IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection
The significance of Th17 cells and interleukin- (IL-)17A signaling in host defense and disease development has been demonstrated in various infection and autoimmune models. Numerous studies have indicated that Th17 cells and its signature cytokine IL-17A are critical to the airway’s immune response...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/267971 |
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| _version_ | 1832553596525215744 |
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| author | Hsing-Chuan Tsai Sharlene Velichko Li-Yin Hung Reen Wu |
| author_facet | Hsing-Chuan Tsai Sharlene Velichko Li-Yin Hung Reen Wu |
| author_sort | Hsing-Chuan Tsai |
| collection | DOAJ |
| description | The significance of Th17 cells and interleukin- (IL-)17A signaling in host defense and disease development has been demonstrated in various infection and autoimmune models. Numerous studies have indicated that Th17 cells and its signature cytokine IL-17A are critical to the airway’s immune response against various bacteria and fungal infection. Cytokines such as IL-23, which are involved in Th17 differentiation, play a critical role in controlling Klebsiella pneumonia (K. pneumonia) infection. IL-17A acts on nonimmune cells in infected tissues to strengthen innate immunity by inducing the expression of antimicrobial proteins, cytokines, and chemokines. Mice deficient in IL-17 receptor (IL-17R) expression are susceptible to infection by various pathogens. In this review, we summarize the recent advances in unraveling the mechanism behind Th17 cell differentiation, IL-17A/IL-17R signaling, and also the importance of IL-17A in pulmonary infection. |
| format | Article |
| id | doaj-art-298477e320b641da961928c04643a9e5 |
| institution | Kabale University |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-298477e320b641da961928c04643a9e52025-02-03T05:53:40ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/267971267971IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against InfectionHsing-Chuan Tsai0Sharlene Velichko1Li-Yin Hung2Reen Wu3Center for Comparative Respiratory Biology and Medicine, University of California, Davis, CA 95616, USACenter for Comparative Respiratory Biology and Medicine, University of California, Davis, CA 95616, USACenter for Comparative Respiratory Biology and Medicine, University of California, Davis, CA 95616, USACenter for Comparative Respiratory Biology and Medicine, University of California, Davis, CA 95616, USAThe significance of Th17 cells and interleukin- (IL-)17A signaling in host defense and disease development has been demonstrated in various infection and autoimmune models. Numerous studies have indicated that Th17 cells and its signature cytokine IL-17A are critical to the airway’s immune response against various bacteria and fungal infection. Cytokines such as IL-23, which are involved in Th17 differentiation, play a critical role in controlling Klebsiella pneumonia (K. pneumonia) infection. IL-17A acts on nonimmune cells in infected tissues to strengthen innate immunity by inducing the expression of antimicrobial proteins, cytokines, and chemokines. Mice deficient in IL-17 receptor (IL-17R) expression are susceptible to infection by various pathogens. In this review, we summarize the recent advances in unraveling the mechanism behind Th17 cell differentiation, IL-17A/IL-17R signaling, and also the importance of IL-17A in pulmonary infection.http://dx.doi.org/10.1155/2013/267971 |
| spellingShingle | Hsing-Chuan Tsai Sharlene Velichko Li-Yin Hung Reen Wu IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection Clinical and Developmental Immunology |
| title | IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection |
| title_full | IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection |
| title_fullStr | IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection |
| title_full_unstemmed | IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection |
| title_short | IL-17A and Th17 Cells in Lung Inflammation: An Update on the Role of Th17 Cell Differentiation and IL-17R Signaling in Host Defense against Infection |
| title_sort | il 17a and th17 cells in lung inflammation an update on the role of th17 cell differentiation and il 17r signaling in host defense against infection |
| url | http://dx.doi.org/10.1155/2013/267971 |
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