Psychosis of Epilepsy: An Update on Clinical Classification and Mechanism
Epilepsy is a prevalent chronic neurological disorder that can significantly impact patients’ lives. The incidence and risk of psychosis in individuals with epilepsy are notably higher than in the general population, adversely affecting both the management and rehabilitation of epilepsy and further...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Online Access: | https://www.mdpi.com/2218-273X/15/1/56 |
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| author | Zhiruo Qiu Jiahui Guo Bofei Chen Jiajia Fang |
| author_facet | Zhiruo Qiu Jiahui Guo Bofei Chen Jiajia Fang |
| author_sort | Zhiruo Qiu |
| collection | DOAJ |
| description | Epilepsy is a prevalent chronic neurological disorder that can significantly impact patients’ lives. The incidence and risk of psychosis in individuals with epilepsy are notably higher than in the general population, adversely affecting both the management and rehabilitation of epilepsy and further diminishing patients’ quality of life. This review provides an overview of the classification and clinical features of psychosis of epilepsy, with the aim of offering insights and references for the clinical diagnosis and treatment of various types of psychosis of epilepsy. Additionally, we examine the potential pathophysiological mechanisms underlying the psychosis of epilepsy from three perspectives: neuroimaging, neurobiology, and genetics. The alterations in brain structure and function, neurotransmitters, neuroinflammatory mediators, and genetic factors discussed in this review may offer insights into the onset and progression of psychotic symptoms in epilepsy patients and are anticipated to inform the identification of novel therapeutic targets in the future. |
| format | Article |
| id | doaj-art-298421dc39e6432086223fceb88ad642 |
| institution | Kabale University |
| issn | 2218-273X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-298421dc39e6432086223fceb88ad6422025-01-24T13:25:01ZengMDPI AGBiomolecules2218-273X2025-01-011515610.3390/biom15010056Psychosis of Epilepsy: An Update on Clinical Classification and MechanismZhiruo Qiu0Jiahui Guo1Bofei Chen2Jiajia Fang3Department of Neurology, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu 322000, ChinaDepartment of Neurology, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu 322000, ChinaDepartment of Neurology, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu 322000, ChinaDepartment of Neurology, The Fourth Affiliated Hospital, International Institutes of Medicine, Zhejiang University School of Medicine, Yiwu 322000, ChinaEpilepsy is a prevalent chronic neurological disorder that can significantly impact patients’ lives. The incidence and risk of psychosis in individuals with epilepsy are notably higher than in the general population, adversely affecting both the management and rehabilitation of epilepsy and further diminishing patients’ quality of life. This review provides an overview of the classification and clinical features of psychosis of epilepsy, with the aim of offering insights and references for the clinical diagnosis and treatment of various types of psychosis of epilepsy. Additionally, we examine the potential pathophysiological mechanisms underlying the psychosis of epilepsy from three perspectives: neuroimaging, neurobiology, and genetics. The alterations in brain structure and function, neurotransmitters, neuroinflammatory mediators, and genetic factors discussed in this review may offer insights into the onset and progression of psychotic symptoms in epilepsy patients and are anticipated to inform the identification of novel therapeutic targets in the future.https://www.mdpi.com/2218-273X/15/1/56psychosis of epilepsymechanismbiomarkersneuroimagingneurobiologygenetics |
| spellingShingle | Zhiruo Qiu Jiahui Guo Bofei Chen Jiajia Fang Psychosis of Epilepsy: An Update on Clinical Classification and Mechanism Biomolecules psychosis of epilepsy mechanism biomarkers neuroimaging neurobiology genetics |
| title | Psychosis of Epilepsy: An Update on Clinical Classification and Mechanism |
| title_full | Psychosis of Epilepsy: An Update on Clinical Classification and Mechanism |
| title_fullStr | Psychosis of Epilepsy: An Update on Clinical Classification and Mechanism |
| title_full_unstemmed | Psychosis of Epilepsy: An Update on Clinical Classification and Mechanism |
| title_short | Psychosis of Epilepsy: An Update on Clinical Classification and Mechanism |
| title_sort | psychosis of epilepsy an update on clinical classification and mechanism |
| topic | psychosis of epilepsy mechanism biomarkers neuroimaging neurobiology genetics |
| url | https://www.mdpi.com/2218-273X/15/1/56 |
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