On Patient Quality of Life: Impacts of Knee Osteoarthritis on Pain, Anxiety, Depression, Fatigue and Sleep Disorders

ABSTRACT Aim Patients repeatedly experiencing a sustained disease course, recurrent chronic pain, and serious sleep disorder will weaken their physical resistance and self‐care ability. Further evidence on patients with knee osteoarthritis (KOA) and related latent classes (LCs) of symptom clusters i...

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Bibliographic Details
Main Authors: Guang‐Zhao Li, Rong‐Jian Ji, Cui Ping Xu, Li‐Juan Yang, Paulo Moreira
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Nursing Open
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Online Access:https://doi.org/10.1002/nop2.70264
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Summary:ABSTRACT Aim Patients repeatedly experiencing a sustained disease course, recurrent chronic pain, and serious sleep disorder will weaken their physical resistance and self‐care ability. Further evidence on patients with knee osteoarthritis (KOA) and related latent classes (LCs) of symptom clusters is needed in order to clarify its significance for symptom management and quality of life (QoL) enhancement. Design This study aimed to generate evidence on differences in symptoms experienced by patients with knee osteoarthritis, identify related LCs, and explore the differences of each LC by demographic, disease, individual characteristics, and QoL. Methods A convenience sample of 230 participants with knee osteoarthritis was surveyed. Sociodemographic and symptom questionnaires were collected. The analysis focused on the influencing factors that are associated with LC, intergroup differences, and associated QoL impacts. Results A total of 230 participants with knee osteoarthritis completed the survey, average age was 64.54 ± 7.59. Three LCs were associated with knee osteoarthritis: LC1 (low symptom class), LC2 (high psychological disorder class) and LC3 (high fatigue with sleep disorder class), accounting for 56%, 24% and 20% respectively. Compared to LC1, LC2 was related to poor economic status, higher imaging grade and lower self‐efficacy. Notably, being older, being less educated, higher occurrence of chronic diseases, experiencing negative life events and having lower self‐efficacy rose in LC3. Patient or Public Contribution The study identified LCs according to pain, anxiety, depression, fatigue and sleep disorder symptoms among patients with KOA, providing a foundation for further determining whether the clusters vary over time or along disease and treatment trajectory and what their possible synergistic effects are on KOA and associated QoL.
ISSN:2054-1058