Fucoxanthin alleviates renal aging by regulating the oxidative stress process and the inflammatory response in vitro and in vivo models
Objectives Many countries in the world are entering society with an aging population. The kidney is one of the most sensitive organs in the body to aging. Kidney function gradually declines with aging. Renal aging is one of the main triggers of CDK. Therefore, many researchers in the field are looki...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2025-12-01
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| Series: | Redox Report |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/13510002.2025.2511458 |
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| author | Xiaomei Zhang Weidong Qiang Yongxin Guo Jingli Gong Huan Yu Di Wu Pengxiang Tang Ma Yidan Huifeng Zhang Xin Sun |
| author_facet | Xiaomei Zhang Weidong Qiang Yongxin Guo Jingli Gong Huan Yu Di Wu Pengxiang Tang Ma Yidan Huifeng Zhang Xin Sun |
| author_sort | Xiaomei Zhang |
| collection | DOAJ |
| description | Objectives Many countries in the world are entering society with an aging population. The kidney is one of the most sensitive organs in the body to aging. Kidney function gradually declines with aging. Renal aging is one of the main triggers of CDK. Therefore, many researchers in the field are looking for natural, green and healthy anti-renal-aging bioactive molecules.Methods and Results Western-blot, ELISA and indirect immunofluorescence were performed to evaluate the biological activity of fucoxanthin against renal aging in vitro and in vivo models. First, in the in vitro model, we evaluated the effect of fucoxanthin on renal cell senescence. We found that fucoxanthin could alleviate the kidney cell senescence caused by H2O2 by detecting a series of senescence markers. In the in vivo model, the experimental results showed that fucoxanthin could alleviate the aging of the kidney by Sa-β-gal staining and detection of aging-related marker molecules. Furthermore, we also found that fucoxanthin could alleviate kidney fibrosis.Conclusions In this study, our results showed that fucoxanthin was able to alleviate renal aging in vivo and in vitro models, suggesting that fucoxanthin could be a functional food to treat and relieve kidney aging. |
| format | Article |
| id | doaj-art-297f1c333ed84c8da2b570d082766a5b |
| institution | Kabale University |
| issn | 1351-0002 1743-2928 |
| language | English |
| publishDate | 2025-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Redox Report |
| spelling | doaj-art-297f1c333ed84c8da2b570d082766a5b2025-08-20T03:46:04ZengTaylor & Francis GroupRedox Report1351-00021743-29282025-12-0130110.1080/13510002.2025.2511458Fucoxanthin alleviates renal aging by regulating the oxidative stress process and the inflammatory response in vitro and in vivo modelsXiaomei Zhang0Weidong Qiang1Yongxin Guo2Jingli Gong3Huan Yu4Di Wu5Pengxiang Tang6Ma Yidan7Huifeng Zhang8Xin Sun9School of Pharmacy, Jilin Medical University, Jilin, People’s Republic of ChinaCollege of Medicine, Huanghuai University, Zhumadian, People’s Republic of ChinaSchool of Pharmacy, Jilin Medical University, Jilin, People’s Republic of ChinaSchool of Pharmacy, Jilin Medical University, Jilin, People’s Republic of ChinaSchool of Pharmacy, Jilin Medical University, Jilin, People’s Republic of ChinaSchool of Pharmacy, Jilin Medical University, Jilin, People’s Republic of ChinaSchool of Pharmacy, Jilin Medical University, Jilin, People’s Republic of ChinaSchool of Pharmacy, Jilin Medical University, Jilin, People’s Republic of ChinaSchool of Pharmacy, Jilin Medical University, Jilin, People’s Republic of ChinaSchool of Pharmacy, Jilin Medical University, Jilin, People’s Republic of ChinaObjectives Many countries in the world are entering society with an aging population. The kidney is one of the most sensitive organs in the body to aging. Kidney function gradually declines with aging. Renal aging is one of the main triggers of CDK. Therefore, many researchers in the field are looking for natural, green and healthy anti-renal-aging bioactive molecules.Methods and Results Western-blot, ELISA and indirect immunofluorescence were performed to evaluate the biological activity of fucoxanthin against renal aging in vitro and in vivo models. First, in the in vitro model, we evaluated the effect of fucoxanthin on renal cell senescence. We found that fucoxanthin could alleviate the kidney cell senescence caused by H2O2 by detecting a series of senescence markers. In the in vivo model, the experimental results showed that fucoxanthin could alleviate the aging of the kidney by Sa-β-gal staining and detection of aging-related marker molecules. Furthermore, we also found that fucoxanthin could alleviate kidney fibrosis.Conclusions In this study, our results showed that fucoxanthin was able to alleviate renal aging in vivo and in vitro models, suggesting that fucoxanthin could be a functional food to treat and relieve kidney aging.https://www.tandfonline.com/doi/10.1080/13510002.2025.2511458Fucoxanthinoxidative stresskidney agingkidney cellinflamationp16 |
| spellingShingle | Xiaomei Zhang Weidong Qiang Yongxin Guo Jingli Gong Huan Yu Di Wu Pengxiang Tang Ma Yidan Huifeng Zhang Xin Sun Fucoxanthin alleviates renal aging by regulating the oxidative stress process and the inflammatory response in vitro and in vivo models Redox Report Fucoxanthin oxidative stress kidney aging kidney cell inflamation p16 |
| title | Fucoxanthin alleviates renal aging by regulating the oxidative stress process and the inflammatory response in vitro and in vivo models |
| title_full | Fucoxanthin alleviates renal aging by regulating the oxidative stress process and the inflammatory response in vitro and in vivo models |
| title_fullStr | Fucoxanthin alleviates renal aging by regulating the oxidative stress process and the inflammatory response in vitro and in vivo models |
| title_full_unstemmed | Fucoxanthin alleviates renal aging by regulating the oxidative stress process and the inflammatory response in vitro and in vivo models |
| title_short | Fucoxanthin alleviates renal aging by regulating the oxidative stress process and the inflammatory response in vitro and in vivo models |
| title_sort | fucoxanthin alleviates renal aging by regulating the oxidative stress process and the inflammatory response in vitro and in vivo models |
| topic | Fucoxanthin oxidative stress kidney aging kidney cell inflamation p16 |
| url | https://www.tandfonline.com/doi/10.1080/13510002.2025.2511458 |
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