The sarcoma ring trial: a case-based analysis of inter-center agreement across 21 German-speaking sarcoma centers
Abstract Purpose The management of soft tissue sarcoma (STS) at reference centers with specialized multidisciplinary tumor boards (MTB) improves patient survival. The German Cancer Society (DKG) certifies sarcoma centers in German-speaking countries, promoting high standards of care. This study inve...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-01-01
|
| Series: | Journal of Cancer Research and Clinical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s00432-024-06063-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823863255062282240 |
|---|---|
| author | Siyer Roohani Jolina Handtke Kamal Hummedah Markus Albertsmeier Dimosthenis Andreou Leonidas Apostolidis Marinela Augustin Sebastian Bauer Moritz Billner Florian Bösch Christoph K. W. Deinzer Niklas Deventer Anna Duprée Franziska Eckert Lars Engel Katja Fechner Hagen Fritzsche Verena Gaidzik Saeed Ghani Robert Grützmann Wiebke K. Guder Rainer Hamacher Judith S. Hecker Anne Hendricks Axel Hillmann Philipp Houben Georg Hübner Philipp Ivanyi Christina Jentsch Maren Jordan Peter Kappl Moritz Kaths Torsten Kessler Johanna Kirchberg Carolin Knebel Robert Krempien Burkhard Lehner Ulrich Lenze Lars H. Lindner Alisa Martina Lörsch Nadia Maguire Sophie Müller Pompiliu Piso Vlatko Potkrajcic Peter Reichardt Stephan Richter Simone Schewe Lars M. Schiffmann Felicitas Scholten Jana Käthe Striefler Matthias Schwarzbach Katharina Seidensaal Sabine Semrau Joanna Szkandera Christoph J. Szuszies Beate Timmermann Armin Tuscherer Armin Wiegering Moritz T. Winkelmann David Kaul Jens Jakob |
| author_facet | Siyer Roohani Jolina Handtke Kamal Hummedah Markus Albertsmeier Dimosthenis Andreou Leonidas Apostolidis Marinela Augustin Sebastian Bauer Moritz Billner Florian Bösch Christoph K. W. Deinzer Niklas Deventer Anna Duprée Franziska Eckert Lars Engel Katja Fechner Hagen Fritzsche Verena Gaidzik Saeed Ghani Robert Grützmann Wiebke K. Guder Rainer Hamacher Judith S. Hecker Anne Hendricks Axel Hillmann Philipp Houben Georg Hübner Philipp Ivanyi Christina Jentsch Maren Jordan Peter Kappl Moritz Kaths Torsten Kessler Johanna Kirchberg Carolin Knebel Robert Krempien Burkhard Lehner Ulrich Lenze Lars H. Lindner Alisa Martina Lörsch Nadia Maguire Sophie Müller Pompiliu Piso Vlatko Potkrajcic Peter Reichardt Stephan Richter Simone Schewe Lars M. Schiffmann Felicitas Scholten Jana Käthe Striefler Matthias Schwarzbach Katharina Seidensaal Sabine Semrau Joanna Szkandera Christoph J. Szuszies Beate Timmermann Armin Tuscherer Armin Wiegering Moritz T. Winkelmann David Kaul Jens Jakob |
| author_sort | Siyer Roohani |
| collection | DOAJ |
| description | Abstract Purpose The management of soft tissue sarcoma (STS) at reference centers with specialized multidisciplinary tumor boards (MTB) improves patient survival. The German Cancer Society (DKG) certifies sarcoma centers in German-speaking countries, promoting high standards of care. This study investigated the variability in treatment recommendations for localized STS across different German-speaking tertiary sarcoma centers. Methods In this cross-sectional case-based survey study, 5 anonymized patient cases with imaging data of localized STS were presented to MTBs of 21 German-speaking tertiary referral hospitals. Centers provided recommendations on treatment sequence and modalities, along with the consensus level within their MTB. Agreement percentages were calculated, and consensus levels were rated on a scale of 1 to 10. Results Five patient cases were discussed resulting in 105 recommendations. Agreement percentages for case 1 to 5 were 14.3%, 61.9%, 33.3%, 52.4% and 9.3%, with a median agreement percentage of 33.3%. Grouping pre- and postoperative therapies as "perioperative" and including recommendations with and without regional hyperthermia raised the median agreement to 47.6%. The mean consensus level within each center across all 5 cases was 9.5. Conclusion This first case-based analysis of inter-center agreement for STS management in German-speaking countries reveals low inter-center agreement but high intra-center consensus. Our study includes nearly all tertiary sarcoma centers in German-speaking countries, affirming its strong external validity. These findings suggest potential and clinically very relevant differences in treatment standards among sarcoma centers. Enhanced case-based exchanges and collaborative efforts are needed to reduce discrepancies and standardize the management of STS patients. |
| format | Article |
| id | doaj-art-297d36c26db64341873dabee2a5116b5 |
| institution | Kabale University |
| issn | 1432-1335 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Cancer Research and Clinical Oncology |
| spelling | doaj-art-297d36c26db64341873dabee2a5116b52025-02-09T12:10:34ZengSpringerJournal of Cancer Research and Clinical Oncology1432-13352025-01-01151111610.1007/s00432-024-06063-zThe sarcoma ring trial: a case-based analysis of inter-center agreement across 21 German-speaking sarcoma centersSiyer Roohani0Jolina Handtke1Kamal Hummedah2Markus Albertsmeier3Dimosthenis Andreou4Leonidas Apostolidis5Marinela Augustin6Sebastian Bauer7Moritz Billner8Florian Bösch9Christoph K. W. Deinzer10Niklas Deventer11Anna Duprée12Franziska Eckert13Lars Engel14Katja Fechner15Hagen Fritzsche16Verena Gaidzik17Saeed Ghani18Robert Grützmann19Wiebke K. Guder20Rainer Hamacher21Judith S. Hecker22Anne Hendricks23Axel Hillmann24Philipp Houben25Georg Hübner26Philipp Ivanyi27Christina Jentsch28Maren Jordan29Peter Kappl30Moritz Kaths31Torsten Kessler32Johanna Kirchberg33Carolin Knebel34Robert Krempien35Burkhard Lehner36Ulrich Lenze37Lars H. Lindner38Alisa Martina Lörsch39Nadia Maguire40Sophie Müller41Pompiliu Piso42Vlatko Potkrajcic43Peter Reichardt44Stephan Richter45Simone Schewe46Lars M. Schiffmann47Felicitas Scholten48Jana Käthe Striefler49Matthias Schwarzbach50Katharina Seidensaal51Sabine Semrau52Joanna Szkandera53Christoph J. Szuszies54Beate Timmermann55Armin Tuscherer56Armin Wiegering57Moritz T. Winkelmann58David Kaul59Jens Jakob60Department of Radiation Oncology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu BerlinDepartment of Radiation Oncology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu BerlinSarcoma Unit, Department of Surgery, University Medical Center and Medical Faculty Mannheim, University of HeidelbergDepartment of General, Visceral and Transplantation Surgery, Ludwig-Maximilians-Universität (LMU) Munich, LMU University HospitalDepartment of Orthopedics and Trauma, Medical University of GrazDepartment of Medical Oncology, Heidelberg University Hospital, National Center for Tumor Diseases (NCT) HeidelbergDepartment of Hematology and Oncology, Paracelsus Medical UniversityDepartment of Medical Oncology and Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical SchoolDepartment of Plastic, Reconstructive and Hand Surgery, Center for Severe Burn Injuries, Paracelsus Medical University, Klinikum NürnbergDepartment of General, Visceral and Pediatric Surgery, University Medical Center GöttingenDepartment of Internal Medicine VIII-Medical Oncology and Pneumology, University Hospital TübingenDepartment for General Orthopaedics and Tumor Orthopaedics, University Hospital MuensterDepartment of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-EppendorfDepartment of Radiation Oncology, University Hospital TübingenDepartment of Visceral-Thoracic and General Surgery, Paracelsus Medical UniversityDepartment of Surgery, University HospitalUniversity Center for Orthopedics, Trauma and Plastic Surgery, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD, Dresden University of TechnologyClinic for Internal Medicine III, University Hospital UlmHelios Klinikum Berlin Buch, SarkomzentrumDepartment of General and Visceral Surgery, Friedrich-Alexander-UniversityDepartment of Orthopedic Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-EssenDepartment of Medical Oncology and Sarcoma Center, West German Cancer Center, University Duisburg-Essen, Medical SchoolDepartment of Medicine III, School of Medicine and Health, Technical University of Munich (TUM)Department of General, Visceral, Transplantation, Vascular, and Pediatric Surgery and Comprehensive Cancer Center Mainfranken Würzburg, University Hospital WürzburgDepartment of Orthopedic and Trauma Surgery, Barmherzige Brüder Regensburg Medical CenterDepartment for General-, Visceral- and Transplant Surgery, University Hospital MuensterDepartment of Radiation Oncology, Barmherzige Brüder Regensburg Medical CenterClinic for Hematology, Hemostaseology, Oncology and Stem Cell Transplantation, Hannover Medical SchoolDepartment of Radiotherapy and Radiation Oncology, Faculty of Medicine and University Hospital Carl Gustav Carus, TUD, Dresden University of TechnologyVarisano Klinikum Frankfurt HöchstDepartment of Radiology, Neuroradiology, and Nuclear Medicine, Barmherzige Brüder Regensburg Medical CenterDKTK Partner Site Essen, German Cancer Consortium (DKTK)Department of Hematology and Oncology, University Hospital MuensterNationales Centrum Für Tumorerkrankungen Dresden (NCT/UCC): Deutsches Krebsforschungszentrum (DKFZ), Universitätsklinikum Carl Gustav Carus Dresden, Medizinische Fakultät der Technischen Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf (HZDR)Department of Orthopaedics and Sports Orthopaedic, Klinikum Rechts Der Isar, Technical University of Munich (TUM)Clinic for Radiotherapy, HELIOS Klinikum Berlin-Buch, SchwanebeckerDepartment of Orthopaedics, Heidelberg University HospitalDepartment of Orthopaedics and Sports Orthopaedic, Klinikum Rechts Der Isar, Technical University of Munich (TUM)SarKUM, Center of Bone and Soft Tissue Tumors, LMU University Hospital, LMU MunichDepartment of Medicine III, School of Medicine and Health, Technical University of Munich (TUM)Department of Oncology and Hematology, Krankenhaus Barmherzige Brüder RegensburgDepartment of General, Visceral, Transplantation, Vascular, and Pediatric Surgery and Comprehensive Cancer Center Mainfranken Würzburg, University Hospital WürzburgDepartment of General and Visceral Surgery, Hospital Barmherzige BrüderDepartment of Radiation Oncology, University Hospital TübingenHelios Klinikum Berlin Buch, SarkomzentrumNationales Centrum Für Tumorerkrankungen Dresden (NCT/UCC): Deutsches Krebsforschungszentrum (DKFZ), Universitätsklinikum Carl Gustav Carus Dresden, Medizinische Fakultät der Technischen Universität Dresden, Helmholtz-Zentrum Dresden-Rossendorf (HZDR)Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-EppendorfDepartment of General, Visceral, Cancer and Transplant Surgery, Faculty of Medicine and University Hospital of Cologne, University of CologneVarisano Klinikum Frankfurt HöchstDepartment of Internal Medicine II, Oncology/Hematology/BMT/Pneumology, University Medical Center Hamburg-EppendorfVarisano Klinikum Frankfurt HöchstDepartment of Radiation Oncology, Heidelberg University HospitalDepartment of Radiation Oncology, University Hospital ErlangenDivision of Clinical Oncology, Department of Internal Medicine, Medical University of GrazDepartment of Hematology and Medical Oncology, University Medical Center GöttingenDKTK Partner Site Essen, German Cancer Consortium (DKTK)Department I of Internal Medicine, Faculty of Medicine and University Hospital, University of CologneDepartment of General, Visceral, Transplantation, Vascular, and Pediatric Surgery and Comprehensive Cancer Center Mainfranken Würzburg, University Hospital WürzburgDepartment for Diagnostic and Interventional Radiology, University Hospital TübingenDepartment of Radiation Oncology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu BerlinSarcoma Unit, Department of Surgery, University Medical Center and Medical Faculty Mannheim, University of HeidelbergAbstract Purpose The management of soft tissue sarcoma (STS) at reference centers with specialized multidisciplinary tumor boards (MTB) improves patient survival. The German Cancer Society (DKG) certifies sarcoma centers in German-speaking countries, promoting high standards of care. This study investigated the variability in treatment recommendations for localized STS across different German-speaking tertiary sarcoma centers. Methods In this cross-sectional case-based survey study, 5 anonymized patient cases with imaging data of localized STS were presented to MTBs of 21 German-speaking tertiary referral hospitals. Centers provided recommendations on treatment sequence and modalities, along with the consensus level within their MTB. Agreement percentages were calculated, and consensus levels were rated on a scale of 1 to 10. Results Five patient cases were discussed resulting in 105 recommendations. Agreement percentages for case 1 to 5 were 14.3%, 61.9%, 33.3%, 52.4% and 9.3%, with a median agreement percentage of 33.3%. Grouping pre- and postoperative therapies as "perioperative" and including recommendations with and without regional hyperthermia raised the median agreement to 47.6%. The mean consensus level within each center across all 5 cases was 9.5. Conclusion This first case-based analysis of inter-center agreement for STS management in German-speaking countries reveals low inter-center agreement but high intra-center consensus. Our study includes nearly all tertiary sarcoma centers in German-speaking countries, affirming its strong external validity. These findings suggest potential and clinically very relevant differences in treatment standards among sarcoma centers. Enhanced case-based exchanges and collaborative efforts are needed to reduce discrepancies and standardize the management of STS patients.https://doi.org/10.1007/s00432-024-06063-zSoft tissue sarcomaRing trialReference centerInter-center agreementGerman Cancer SocietyGuidelines |
| spellingShingle | Siyer Roohani Jolina Handtke Kamal Hummedah Markus Albertsmeier Dimosthenis Andreou Leonidas Apostolidis Marinela Augustin Sebastian Bauer Moritz Billner Florian Bösch Christoph K. W. Deinzer Niklas Deventer Anna Duprée Franziska Eckert Lars Engel Katja Fechner Hagen Fritzsche Verena Gaidzik Saeed Ghani Robert Grützmann Wiebke K. Guder Rainer Hamacher Judith S. Hecker Anne Hendricks Axel Hillmann Philipp Houben Georg Hübner Philipp Ivanyi Christina Jentsch Maren Jordan Peter Kappl Moritz Kaths Torsten Kessler Johanna Kirchberg Carolin Knebel Robert Krempien Burkhard Lehner Ulrich Lenze Lars H. Lindner Alisa Martina Lörsch Nadia Maguire Sophie Müller Pompiliu Piso Vlatko Potkrajcic Peter Reichardt Stephan Richter Simone Schewe Lars M. Schiffmann Felicitas Scholten Jana Käthe Striefler Matthias Schwarzbach Katharina Seidensaal Sabine Semrau Joanna Szkandera Christoph J. Szuszies Beate Timmermann Armin Tuscherer Armin Wiegering Moritz T. Winkelmann David Kaul Jens Jakob The sarcoma ring trial: a case-based analysis of inter-center agreement across 21 German-speaking sarcoma centers Journal of Cancer Research and Clinical Oncology Soft tissue sarcoma Ring trial Reference center Inter-center agreement German Cancer Society Guidelines |
| title | The sarcoma ring trial: a case-based analysis of inter-center agreement across 21 German-speaking sarcoma centers |
| title_full | The sarcoma ring trial: a case-based analysis of inter-center agreement across 21 German-speaking sarcoma centers |
| title_fullStr | The sarcoma ring trial: a case-based analysis of inter-center agreement across 21 German-speaking sarcoma centers |
| title_full_unstemmed | The sarcoma ring trial: a case-based analysis of inter-center agreement across 21 German-speaking sarcoma centers |
| title_short | The sarcoma ring trial: a case-based analysis of inter-center agreement across 21 German-speaking sarcoma centers |
| title_sort | sarcoma ring trial a case based analysis of inter center agreement across 21 german speaking sarcoma centers |
| topic | Soft tissue sarcoma Ring trial Reference center Inter-center agreement German Cancer Society Guidelines |
| url | https://doi.org/10.1007/s00432-024-06063-z |
| work_keys_str_mv | AT siyerroohani thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT jolinahandtke thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT kamalhummedah thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT markusalbertsmeier thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT dimosthenisandreou thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT leonidasapostolidis thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT marinelaaugustin thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT sebastianbauer thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT moritzbillner thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT florianbosch thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT christophkwdeinzer thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT niklasdeventer thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT annadupree thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT franziskaeckert thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT larsengel thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT katjafechner thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT hagenfritzsche thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT verenagaidzik thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT saeedghani thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT robertgrutzmann thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT wiebkekguder thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT rainerhamacher thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT judithshecker thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT annehendricks thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT axelhillmann thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT philipphouben thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT georghubner thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT philippivanyi thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT christinajentsch thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT marenjordan thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT peterkappl thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT moritzkaths thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT torstenkessler thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT johannakirchberg thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT carolinknebel thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT robertkrempien thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT burkhardlehner thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT ulrichlenze thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT larshlindner thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT alisamartinalorsch thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT nadiamaguire thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT sophiemuller thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT pompiliupiso thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT vlatkopotkrajcic thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT peterreichardt thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT stephanrichter thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT simoneschewe thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT larsmschiffmann thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT felicitasscholten thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT janakathestriefler thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT matthiasschwarzbach thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT katharinaseidensaal thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT sabinesemrau thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT joannaszkandera thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT christophjszuszies thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT beatetimmermann thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT armintuscherer thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT arminwiegering thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT moritztwinkelmann thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT davidkaul thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT jensjakob thesarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT siyerroohani sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT jolinahandtke sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT kamalhummedah sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT markusalbertsmeier sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT dimosthenisandreou sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT leonidasapostolidis sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT marinelaaugustin sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT sebastianbauer sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT moritzbillner sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT florianbosch sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT christophkwdeinzer sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT niklasdeventer sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT annadupree sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT franziskaeckert sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT larsengel sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT katjafechner sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT hagenfritzsche sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT verenagaidzik sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT saeedghani sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT robertgrutzmann sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT wiebkekguder sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT rainerhamacher sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT judithshecker sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT annehendricks sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT axelhillmann sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT philipphouben sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT georghubner sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT philippivanyi sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT christinajentsch sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT marenjordan sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT peterkappl sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT moritzkaths sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT torstenkessler sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT johannakirchberg sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT carolinknebel sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT robertkrempien sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT burkhardlehner sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT ulrichlenze sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT larshlindner sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT alisamartinalorsch sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT nadiamaguire sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT sophiemuller sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT pompiliupiso sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT vlatkopotkrajcic sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT peterreichardt sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT stephanrichter sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT simoneschewe sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT larsmschiffmann sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT felicitasscholten sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT janakathestriefler sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT matthiasschwarzbach sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT katharinaseidensaal sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT sabinesemrau sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT joannaszkandera sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT christophjszuszies sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT beatetimmermann sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT armintuscherer sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT arminwiegering sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT moritztwinkelmann sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT davidkaul sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters AT jensjakob sarcomaringtrialacasebasedanalysisofintercenteragreementacross21germanspeakingsarcomacenters |