Trends in nontuberculous mycobacterial disease mortality based on 2000-2022 data from 83 countries
Objectives: To examine the international trends for nontuberculous mycobacterial-associated mortality rates, as nontuberculous mycobacterial infections are becoming increasingly prevalent and pose a significant public health challenge, especially in older populations. Methods: This retrospective obs...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-09-01
|
| Series: | International Journal of Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971225001560 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850028064800505856 |
|---|---|
| author | Ko Harada Quynh Thi Vu Yoshito Nishimura Tatsuaki Takeda Hirofumi Hamano Yusuke Minato Yoshito Zamami Toshihiro Koyama Hideharu Hagiya |
| author_facet | Ko Harada Quynh Thi Vu Yoshito Nishimura Tatsuaki Takeda Hirofumi Hamano Yusuke Minato Yoshito Zamami Toshihiro Koyama Hideharu Hagiya |
| author_sort | Ko Harada |
| collection | DOAJ |
| description | Objectives: To examine the international trends for nontuberculous mycobacterial-associated mortality rates, as nontuberculous mycobacterial infections are becoming increasingly prevalent and pose a significant public health challenge, especially in older populations. Methods: This retrospective observational study used data from the World Health Organization mortality database, which included patients with nontuberculous mycobacterial infection in 83 countries. We stratified the data by sex, age, and geographic region and calculated crude and age-standardized mortality rates to estimate long-term mortality trends. Results: In total, 42,182 nontuberculous mycobacterial infection-associated deaths (58.1% in women) were reported in 83 countries between 2000 and 2022. The locally weighted regression model estimation for the nontuberculous mycobacterial infection-associated mortality rate more than doubled—from 0.36 deaths per 1000,000 individuals in 2000 to 0.77 deaths per 1000,000 individuals in 2022. Eighty-six percent of nontuberculous mycobacterial infection-associated deaths occurred in people aged ≥65 years. The mortality rate was the highest in the Western Pacific Region. Conclusion: This study highlights the impact of emerging nontuberculous mycobacterial diseases and the importance of targeted interventions for managing and reducing mortality, particularly in vulnerable older populations. Further studies are warranted to determine the factors contributing to geographical disparity and treatment options. |
| format | Article |
| id | doaj-art-297b59aaf0a643cda49653d24f35c5f1 |
| institution | DOAJ |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj-art-297b59aaf0a643cda49653d24f35c5f12025-08-20T02:59:57ZengElsevierInternational Journal of Infectious Diseases1201-97122025-09-0115810793210.1016/j.ijid.2025.107932Trends in nontuberculous mycobacterial disease mortality based on 2000-2022 data from 83 countriesKo Harada0Quynh Thi Vu1Yoshito Nishimura2Tatsuaki Takeda3Hirofumi Hamano4Yusuke Minato5Yoshito Zamami6Toshihiro Koyama7Hideharu Hagiya8Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USADepartment of Health Data Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, JapanDivision of Hematology/Oncology, Mayo Clinic, Rochester, MN, USADepartment of Education and Research Centre for Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Okayama University, Okayama, JapanDepartment of Pharmacy, Okayama University Hospital, Okayama, JapanCenter for Infectious Disease Research, Fujita Health University, Aichi, JapanDepartment of Pharmacy, Okayama University Hospital, Okayama, JapanDepartment of Health Data Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan; Corresponding author: Toshihiro Koyama, Department of Health Data Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 7008558, Japan.Department of Infectious Diseases, Okayama University Hospital, Okayama, JapanObjectives: To examine the international trends for nontuberculous mycobacterial-associated mortality rates, as nontuberculous mycobacterial infections are becoming increasingly prevalent and pose a significant public health challenge, especially in older populations. Methods: This retrospective observational study used data from the World Health Organization mortality database, which included patients with nontuberculous mycobacterial infection in 83 countries. We stratified the data by sex, age, and geographic region and calculated crude and age-standardized mortality rates to estimate long-term mortality trends. Results: In total, 42,182 nontuberculous mycobacterial infection-associated deaths (58.1% in women) were reported in 83 countries between 2000 and 2022. The locally weighted regression model estimation for the nontuberculous mycobacterial infection-associated mortality rate more than doubled—from 0.36 deaths per 1000,000 individuals in 2000 to 0.77 deaths per 1000,000 individuals in 2022. Eighty-six percent of nontuberculous mycobacterial infection-associated deaths occurred in people aged ≥65 years. The mortality rate was the highest in the Western Pacific Region. Conclusion: This study highlights the impact of emerging nontuberculous mycobacterial diseases and the importance of targeted interventions for managing and reducing mortality, particularly in vulnerable older populations. Further studies are warranted to determine the factors contributing to geographical disparity and treatment options.http://www.sciencedirect.com/science/article/pii/S1201971225001560Population surveillanceMortalityNontuberculous mycobacterial infections |
| spellingShingle | Ko Harada Quynh Thi Vu Yoshito Nishimura Tatsuaki Takeda Hirofumi Hamano Yusuke Minato Yoshito Zamami Toshihiro Koyama Hideharu Hagiya Trends in nontuberculous mycobacterial disease mortality based on 2000-2022 data from 83 countries International Journal of Infectious Diseases Population surveillance Mortality Nontuberculous mycobacterial infections |
| title | Trends in nontuberculous mycobacterial disease mortality based on 2000-2022 data from 83 countries |
| title_full | Trends in nontuberculous mycobacterial disease mortality based on 2000-2022 data from 83 countries |
| title_fullStr | Trends in nontuberculous mycobacterial disease mortality based on 2000-2022 data from 83 countries |
| title_full_unstemmed | Trends in nontuberculous mycobacterial disease mortality based on 2000-2022 data from 83 countries |
| title_short | Trends in nontuberculous mycobacterial disease mortality based on 2000-2022 data from 83 countries |
| title_sort | trends in nontuberculous mycobacterial disease mortality based on 2000 2022 data from 83 countries |
| topic | Population surveillance Mortality Nontuberculous mycobacterial infections |
| url | http://www.sciencedirect.com/science/article/pii/S1201971225001560 |
| work_keys_str_mv | AT koharada trendsinnontuberculousmycobacterialdiseasemortalitybasedon20002022datafrom83countries AT quynhthivu trendsinnontuberculousmycobacterialdiseasemortalitybasedon20002022datafrom83countries AT yoshitonishimura trendsinnontuberculousmycobacterialdiseasemortalitybasedon20002022datafrom83countries AT tatsuakitakeda trendsinnontuberculousmycobacterialdiseasemortalitybasedon20002022datafrom83countries AT hirofumihamano trendsinnontuberculousmycobacterialdiseasemortalitybasedon20002022datafrom83countries AT yusukeminato trendsinnontuberculousmycobacterialdiseasemortalitybasedon20002022datafrom83countries AT yoshitozamami trendsinnontuberculousmycobacterialdiseasemortalitybasedon20002022datafrom83countries AT toshihirokoyama trendsinnontuberculousmycobacterialdiseasemortalitybasedon20002022datafrom83countries AT hideharuhagiya trendsinnontuberculousmycobacterialdiseasemortalitybasedon20002022datafrom83countries |