Cortico-striatal circuit mechanisms drive the effects of D1 dopamine agonists on memory capacity in mice through cAMP/PKA signalling

Cortico-striatal circuit mechanisms drive the effects of D1 dopamine agonists on memory capacity in mice through cAMP/PKA signalling

Abstract Working memory capacity (WMC), the number of items remembered in a short-time interval, is regulated by fronto-striatal dopamine (DA) and is reduced in schizophrenia. We investigated how excessive and insufficient D1 dopamine receptor stimulation impairs and expands WMC, focusing on the cAM...

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Main Authors: Maria De Risi, Diletta Cavezza, Giulia Torromino, Anita Capalbo, Xabier Bujanda Cundin, Rosaria Di Martino, Filomena Grazia Alvino, Attilio Iemolo, Luisa Speranza, Carla Perrone-Capano, Marianna Crispino, Carmine Cirillo, Alberto Luini, Francesca Sacco, Paolo Grumati, Elvira De Leonibus
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57788-5
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