Retrospective study of chidamide-containing regimens as maintenance therapy among T- and NK-cell lymphoma patients
ObjectiveThis study aimed to explore the efficacy of chidamide-containing regimens as maintenance therapy in patients with T- and natural killer (NK)-cell lymphomas (TNKLs).MethodsA total of 51 patients with TNKLs who received chidamide-containing regimens after induction therapy were enrolled. The...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1507418/full |
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| author | Tao Hai Wanchun Wu Kexin Ren Na Li Liqun Zou |
| author_facet | Tao Hai Wanchun Wu Kexin Ren Na Li Liqun Zou |
| author_sort | Tao Hai |
| collection | DOAJ |
| description | ObjectiveThis study aimed to explore the efficacy of chidamide-containing regimens as maintenance therapy in patients with T- and natural killer (NK)-cell lymphomas (TNKLs).MethodsA total of 51 patients with TNKLs who received chidamide-containing regimens after induction therapy were enrolled. The primary end point was progression-free survival (PFS), while the secondary end point was overall survival (OS) and safety.ResultsThe median duration of maintenance was 14 months (range = 1–24 months). Most of the patients were diagnosed with extranodal NK/T-cell lymphoma (ENKTCL; 24/51, 47.1%), followed by angioimmunoblastic T-cell lymphoma (AITL; 14/51, 27.5%). The median PFS and OS were 21 and 29 months, respectively. The 2-year PFS and OS among the overall population were 45.1% and 54.2%, respectively. Patients who experienced complete remission (CR) after induction therapy had favorable survival compared with non-CR patients (partial remission/stable disease, PR/SD). Patients who experienced CR after first-line induction treatment also had favorable survival, but similar significance was not observed in the salvage treatment group. Although 86.3% of the patients had chidamide-related adverse events (AEs), severe hematological AEs (grade ≥3) occurred in only 11 (21.6%) patients, indicating the safe toxicity profile of chidamide.ConclusionThe prolonged survival indicated that chidamide-containing maintenance therapy is promising and well tolerated in patients with TNKLs. |
| format | Article |
| id | doaj-art-296f69f08c3248d8884fcc3cb3452fe0 |
| institution | DOAJ |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Oncology |
| spelling | doaj-art-296f69f08c3248d8884fcc3cb3452fe02025-08-20T03:00:50ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-03-011510.3389/fonc.2025.15074181507418Retrospective study of chidamide-containing regimens as maintenance therapy among T- and NK-cell lymphoma patientsTao HaiWanchun WuKexin RenNa LiLiqun ZouObjectiveThis study aimed to explore the efficacy of chidamide-containing regimens as maintenance therapy in patients with T- and natural killer (NK)-cell lymphomas (TNKLs).MethodsA total of 51 patients with TNKLs who received chidamide-containing regimens after induction therapy were enrolled. The primary end point was progression-free survival (PFS), while the secondary end point was overall survival (OS) and safety.ResultsThe median duration of maintenance was 14 months (range = 1–24 months). Most of the patients were diagnosed with extranodal NK/T-cell lymphoma (ENKTCL; 24/51, 47.1%), followed by angioimmunoblastic T-cell lymphoma (AITL; 14/51, 27.5%). The median PFS and OS were 21 and 29 months, respectively. The 2-year PFS and OS among the overall population were 45.1% and 54.2%, respectively. Patients who experienced complete remission (CR) after induction therapy had favorable survival compared with non-CR patients (partial remission/stable disease, PR/SD). Patients who experienced CR after first-line induction treatment also had favorable survival, but similar significance was not observed in the salvage treatment group. Although 86.3% of the patients had chidamide-related adverse events (AEs), severe hematological AEs (grade ≥3) occurred in only 11 (21.6%) patients, indicating the safe toxicity profile of chidamide.ConclusionThe prolonged survival indicated that chidamide-containing maintenance therapy is promising and well tolerated in patients with TNKLs.https://www.frontiersin.org/articles/10.3389/fonc.2025.1507418/fullchidamideT and NK-cell lymphomamaintenance therapysurvivalsafety |
| spellingShingle | Tao Hai Wanchun Wu Kexin Ren Na Li Liqun Zou Retrospective study of chidamide-containing regimens as maintenance therapy among T- and NK-cell lymphoma patients Frontiers in Oncology chidamide T and NK-cell lymphoma maintenance therapy survival safety |
| title | Retrospective study of chidamide-containing regimens as maintenance therapy among T- and NK-cell lymphoma patients |
| title_full | Retrospective study of chidamide-containing regimens as maintenance therapy among T- and NK-cell lymphoma patients |
| title_fullStr | Retrospective study of chidamide-containing regimens as maintenance therapy among T- and NK-cell lymphoma patients |
| title_full_unstemmed | Retrospective study of chidamide-containing regimens as maintenance therapy among T- and NK-cell lymphoma patients |
| title_short | Retrospective study of chidamide-containing regimens as maintenance therapy among T- and NK-cell lymphoma patients |
| title_sort | retrospective study of chidamide containing regimens as maintenance therapy among t and nk cell lymphoma patients |
| topic | chidamide T and NK-cell lymphoma maintenance therapy survival safety |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1507418/full |
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