T-lymphocytes suppression by CD14+ monocytes with high expression of ULK2 in patients with multiple myeloma

T-lymphocytes suppression by CD14+ monocytes with high expression of ULK2 in patients with multiple myeloma

Abstract Background Multiple myeloma (MM), a plasma cell malignancy, remains incurable and is highly prone to relapse. Immunosuppressive cells in the bone marrow environment inhibit endogenous T-lymphocytes activity and reduce the efficacy immunotherapies. Abnormal bone marrow monocytes in MM have b...

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Bibliographic Details
Main Authors: Fengping Peng, Zhaoyun Liu, Fengjuan Jiang, Nianbin Li, Hao Wang, Nanhao Meng, Hui Liu, Kai Ding, Rong Fu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Translational Medicine
Subjects:
Multiple myeloma
CD14+ monocytes
T-lymphocytes
ULK2
Online Access:https://doi.org/10.1186/s12967-025-06516-0
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