Structural and functional insights of AmpG in muropeptide transport and multiple β-lactam antibiotics resistance

Abstract Anhydromuropeptide permease (AmpG) is a transporter protein located in the inner membrane of certain gram -negative bacteria, involved in peptidoglycan (PG) recycling and β-lactamase induction. Decreased AmpG function reduces resistance of antibiotic-resistant bacteria to β-lactam antibioti...

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Main Authors: Nienping Chang, Hoyoung Kim, Uijin Kim, Yongju Cho, Youngki Yoo, Hyunsook Lee, Ji Won Kim, Min Sung Kim, Jaeho Lee, Young-Lag Cho, Kitae Kim, Dongeun Yong, Hyun-Soo Cho
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-61169-3
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