Biopolymers for Liver Tissue Engineering: A Systematic Review
Stem cell-derived liver cells, organoids, and lab-grown liver tissue are promising regenerative therapies for liver disease. However, current culture conditions are sub-optimal, producing end-target cells and tissue phenotypes that are immature or unstable when compared to primary liver cells and ti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Gels |
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| Online Access: | https://www.mdpi.com/2310-2861/11/7/525 |
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| author | John Ong Jacky Junzhe Zhao Carla Swift Athina E. Markaki |
| author_facet | John Ong Jacky Junzhe Zhao Carla Swift Athina E. Markaki |
| author_sort | John Ong |
| collection | DOAJ |
| description | Stem cell-derived liver cells, organoids, and lab-grown liver tissue are promising regenerative therapies for liver disease. However, current culture conditions are sub-optimal, producing end-target cells and tissue phenotypes that are immature or unstable when compared to primary liver cells and tissue. Biopolymers used in culture substrates and scaffolds for tissue engineering significantly impact the quality of the end-target cells and tissue, influencing the efficacy of regenerative treatments. In addition, the biochemical properties of some biopolymers may preclude the translation of downstream bioengineered products into clinical practice. Therefore, this systematic review aims to evaluate the recent advances in biopolymers within liver tissue engineering, providing an overview of the current usage in the field and highlighting novel substrates that have strong potential to be translated into clinical therapy. |
| format | Article |
| id | doaj-art-29686aa50afe406ebf512543db29bab5 |
| institution | Kabale University |
| issn | 2310-2861 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Gels |
| spelling | doaj-art-29686aa50afe406ebf512543db29bab52025-08-20T03:58:30ZengMDPI AGGels2310-28612025-07-0111752510.3390/gels11070525Biopolymers for Liver Tissue Engineering: A Systematic ReviewJohn Ong0Jacky Junzhe Zhao1Carla Swift2Athina E. Markaki3Cambridge Stem Cell Institute, University of Cambridge, Cambridge CB2 0AW, UKDuke-NUS Medical School, Singapore 169857, SingaporeBedfordshire Hospitals NHS Trust, Bedford Hospital, Bedford MK42 9DJ, UKDepartment of Engineering, University of Cambridge, Cambridge CB2 1PZ, UKStem cell-derived liver cells, organoids, and lab-grown liver tissue are promising regenerative therapies for liver disease. However, current culture conditions are sub-optimal, producing end-target cells and tissue phenotypes that are immature or unstable when compared to primary liver cells and tissue. Biopolymers used in culture substrates and scaffolds for tissue engineering significantly impact the quality of the end-target cells and tissue, influencing the efficacy of regenerative treatments. In addition, the biochemical properties of some biopolymers may preclude the translation of downstream bioengineered products into clinical practice. Therefore, this systematic review aims to evaluate the recent advances in biopolymers within liver tissue engineering, providing an overview of the current usage in the field and highlighting novel substrates that have strong potential to be translated into clinical therapy.https://www.mdpi.com/2310-2861/11/7/525biopolymershydrogelsscaffoldssubstratesstem cellshepatocytes |
| spellingShingle | John Ong Jacky Junzhe Zhao Carla Swift Athina E. Markaki Biopolymers for Liver Tissue Engineering: A Systematic Review Gels biopolymers hydrogels scaffolds substrates stem cells hepatocytes |
| title | Biopolymers for Liver Tissue Engineering: A Systematic Review |
| title_full | Biopolymers for Liver Tissue Engineering: A Systematic Review |
| title_fullStr | Biopolymers for Liver Tissue Engineering: A Systematic Review |
| title_full_unstemmed | Biopolymers for Liver Tissue Engineering: A Systematic Review |
| title_short | Biopolymers for Liver Tissue Engineering: A Systematic Review |
| title_sort | biopolymers for liver tissue engineering a systematic review |
| topic | biopolymers hydrogels scaffolds substrates stem cells hepatocytes |
| url | https://www.mdpi.com/2310-2861/11/7/525 |
| work_keys_str_mv | AT johnong biopolymersforlivertissueengineeringasystematicreview AT jackyjunzhezhao biopolymersforlivertissueengineeringasystematicreview AT carlaswift biopolymersforlivertissueengineeringasystematicreview AT athinaemarkaki biopolymersforlivertissueengineeringasystematicreview |