Thrombotic Microangiopathy Secondary to Sirolimus Monotherapy in Orthotopic Liver Transplant
Sirolimus is a mammalian target of rapamycin (mTOR) inhibitor often used in clinical conjunction with calcineurin inhibitors (CNIs) or mycophenolate mofetil to prevent solid organ transplant rejection. While nephrotoxicity is a well-known side effect of CNIs, renal injury because of mTOR inhibitors...
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| Format: | Article |
| Language: | English |
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American College of Physicians
2024-06-01
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| Series: | Annals of Internal Medicine: Clinical Cases |
| Online Access: | https://www.acpjournals.org/doi/10.7326/aimcc.2023.0960 |
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| author | Tabeer Rana Shivani Shah Lydia Du Sheena Mago Tavankit Singh Mark Bunker |
| author_facet | Tabeer Rana Shivani Shah Lydia Du Sheena Mago Tavankit Singh Mark Bunker |
| author_sort | Tabeer Rana |
| collection | DOAJ |
| description | Sirolimus is a mammalian target of rapamycin (mTOR) inhibitor often used in clinical conjunction with calcineurin inhibitors (CNIs) or mycophenolate mofetil to prevent solid organ transplant rejection. While nephrotoxicity is a well-known side effect of CNIs, renal injury because of mTOR inhibitors is exceedingly rare and limited to case reports, primarily in the setting of renal transplant and post-hematopoietic stem cell transplant. This case demonstrates a rare occurrence of sirolimus-induced thrombotic microangiopathy after orthotopic liver transplant. |
| format | Article |
| id | doaj-art-295b79698aee474690f41ef697289cdf |
| institution | OA Journals |
| issn | 2767-7664 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | American College of Physicians |
| record_format | Article |
| series | Annals of Internal Medicine: Clinical Cases |
| spelling | doaj-art-295b79698aee474690f41ef697289cdf2025-08-20T02:11:45ZengAmerican College of PhysiciansAnnals of Internal Medicine: Clinical Cases2767-76642024-06-013610.7326/aimcc.2023.0960Thrombotic Microangiopathy Secondary to Sirolimus Monotherapy in Orthotopic Liver TransplantTabeer Rana0Shivani Shah1Lydia Du2Sheena Mago3Tavankit Singh4Mark Bunker51Department of Internal Medicine, Allegheny Health Network, Pittsburgh, Pennsylvania1Department of Internal Medicine, Allegheny Health Network, Pittsburgh, Pennsylvania2Department of Pathology, Allegheny Health Network, Pittsburgh, Pennsylvania3Department of Gastroenterology and Hepatology, Allegheny Health Network, Pittsburgh, Pennsylvania3Department of Gastroenterology and Hepatology, Allegheny Health Network, Pittsburgh, Pennsylvania2Department of Pathology, Allegheny Health Network, Pittsburgh, PennsylvaniaSirolimus is a mammalian target of rapamycin (mTOR) inhibitor often used in clinical conjunction with calcineurin inhibitors (CNIs) or mycophenolate mofetil to prevent solid organ transplant rejection. While nephrotoxicity is a well-known side effect of CNIs, renal injury because of mTOR inhibitors is exceedingly rare and limited to case reports, primarily in the setting of renal transplant and post-hematopoietic stem cell transplant. This case demonstrates a rare occurrence of sirolimus-induced thrombotic microangiopathy after orthotopic liver transplant.https://www.acpjournals.org/doi/10.7326/aimcc.2023.0960 |
| spellingShingle | Tabeer Rana Shivani Shah Lydia Du Sheena Mago Tavankit Singh Mark Bunker Thrombotic Microangiopathy Secondary to Sirolimus Monotherapy in Orthotopic Liver Transplant Annals of Internal Medicine: Clinical Cases |
| title | Thrombotic Microangiopathy Secondary to Sirolimus Monotherapy in Orthotopic Liver Transplant |
| title_full | Thrombotic Microangiopathy Secondary to Sirolimus Monotherapy in Orthotopic Liver Transplant |
| title_fullStr | Thrombotic Microangiopathy Secondary to Sirolimus Monotherapy in Orthotopic Liver Transplant |
| title_full_unstemmed | Thrombotic Microangiopathy Secondary to Sirolimus Monotherapy in Orthotopic Liver Transplant |
| title_short | Thrombotic Microangiopathy Secondary to Sirolimus Monotherapy in Orthotopic Liver Transplant |
| title_sort | thrombotic microangiopathy secondary to sirolimus monotherapy in orthotopic liver transplant |
| url | https://www.acpjournals.org/doi/10.7326/aimcc.2023.0960 |
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