Influence of symptom burden on social alienation in lung cancer patients receiving chemotherapy: the chain mediating effect of perceived social support and positive psychological capital
Abstract Background Social alienation is prevalent among lung cancer (LC) patients undergoing chemotherapy. Although previous research has established an association between social alienation and symptom burden, the mechanisms underlying this relationship remain not fully understood. Methods This cr...
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BMC
2025-02-01
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| Series: | BMC Psychology |
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| Online Access: | https://doi.org/10.1186/s40359-025-02403-x |
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| author | Jiahao Wei Ziye Bai Mengru Bu Guining Dang Xiumei Wu Jin Zhou |
| author_facet | Jiahao Wei Ziye Bai Mengru Bu Guining Dang Xiumei Wu Jin Zhou |
| author_sort | Jiahao Wei |
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| description | Abstract Background Social alienation is prevalent among lung cancer (LC) patients undergoing chemotherapy. Although previous research has established an association between social alienation and symptom burden, the mechanisms underlying this relationship remain not fully understood. Methods This cross-sectional study used convenience sampling to select 378 LC patients undergoing chemotherapy from September 2022 to December 2023 at a tertiary care hospital in Guangzhou, China. Data collection was conducted using a proprietary Sociodemographic Information Questionnaire, MD Anderson Symptom Inventory (MDASI), Social Alienation Questionnaire, Perceptions of Social Support (PSS) Questionnaire, and Positive Psychological Capital (PPC) Questionnaire. To analyze chain-mediated effects, the PROCESS v3.3 Model 6 SPSS macro software was employed. Results The analysis revealed that the burden of symptoms significantly exacerbates social alienation, as evidenced in the mediation effects model (Bootstrap 95% CI: 0.031, 0.092). Furthermore, the burden of symptoms indirectly diminishes PSS (Bootstrap 95% CI: 0.019, 0.057) and PPC (Bootstrap 95% CI: 0.002, 0.020). It is crucial to note that both PSS and PPC significantly mediate the relationship between symptom burden and social alienation, as evidenced (Bootstrap 95% CI: 0.001, 0.011). Conclusions The impact of symptom burden on social alienation is moderated through PSS and PPC, manifesting both directly and indirectly. Moreover, the influence of PPC tends to mitigate the mediating role of PSS. Clinical interventions aimed at bolstering PSS and augmenting PPC may potentially alleviate social alienation and enhance the quality of life for patients undergoing chemotherapy for LC. |
| format | Article |
| id | doaj-art-294fa317ca8e4a9487649d3fbdf23cb1 |
| institution | Kabale University |
| issn | 2050-7283 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
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| series | BMC Psychology |
| spelling | doaj-art-294fa317ca8e4a9487649d3fbdf23cb12025-02-09T13:00:24ZengBMCBMC Psychology2050-72832025-02-0113111010.1186/s40359-025-02403-xInfluence of symptom burden on social alienation in lung cancer patients receiving chemotherapy: the chain mediating effect of perceived social support and positive psychological capitalJiahao Wei0Ziye Bai1Mengru Bu2Guining Dang3Xiumei Wu4Jin Zhou5Nursing Department, Integrated Hospital of Traditional Chinese Medicine, Southern Medical UniversityNursing Department, Integrated Hospital of Traditional Chinese Medicine, Southern Medical UniversityNursing Department, Integrated Hospital of Traditional Chinese Medicine, Southern Medical UniversityDepartment of Orthopaedics and Traumatology, Integrated Hospital of Traditional Chinese Medicine, Southern Medical UniversityNursing Department, Integrated Hospital of Traditional Chinese Medicine, Southern Medical UniversityNursing Department, Integrated Hospital of Traditional Chinese Medicine, Southern Medical UniversityAbstract Background Social alienation is prevalent among lung cancer (LC) patients undergoing chemotherapy. Although previous research has established an association between social alienation and symptom burden, the mechanisms underlying this relationship remain not fully understood. Methods This cross-sectional study used convenience sampling to select 378 LC patients undergoing chemotherapy from September 2022 to December 2023 at a tertiary care hospital in Guangzhou, China. Data collection was conducted using a proprietary Sociodemographic Information Questionnaire, MD Anderson Symptom Inventory (MDASI), Social Alienation Questionnaire, Perceptions of Social Support (PSS) Questionnaire, and Positive Psychological Capital (PPC) Questionnaire. To analyze chain-mediated effects, the PROCESS v3.3 Model 6 SPSS macro software was employed. Results The analysis revealed that the burden of symptoms significantly exacerbates social alienation, as evidenced in the mediation effects model (Bootstrap 95% CI: 0.031, 0.092). Furthermore, the burden of symptoms indirectly diminishes PSS (Bootstrap 95% CI: 0.019, 0.057) and PPC (Bootstrap 95% CI: 0.002, 0.020). It is crucial to note that both PSS and PPC significantly mediate the relationship between symptom burden and social alienation, as evidenced (Bootstrap 95% CI: 0.001, 0.011). Conclusions The impact of symptom burden on social alienation is moderated through PSS and PPC, manifesting both directly and indirectly. Moreover, the influence of PPC tends to mitigate the mediating role of PSS. Clinical interventions aimed at bolstering PSS and augmenting PPC may potentially alleviate social alienation and enhance the quality of life for patients undergoing chemotherapy for LC.https://doi.org/10.1186/s40359-025-02403-xLung cancer chemotherapySymptom burdenSocial alienationPerceived social supportPositive psychological capital |
| spellingShingle | Jiahao Wei Ziye Bai Mengru Bu Guining Dang Xiumei Wu Jin Zhou Influence of symptom burden on social alienation in lung cancer patients receiving chemotherapy: the chain mediating effect of perceived social support and positive psychological capital BMC Psychology Lung cancer chemotherapy Symptom burden Social alienation Perceived social support Positive psychological capital |
| title | Influence of symptom burden on social alienation in lung cancer patients receiving chemotherapy: the chain mediating effect of perceived social support and positive psychological capital |
| title_full | Influence of symptom burden on social alienation in lung cancer patients receiving chemotherapy: the chain mediating effect of perceived social support and positive psychological capital |
| title_fullStr | Influence of symptom burden on social alienation in lung cancer patients receiving chemotherapy: the chain mediating effect of perceived social support and positive psychological capital |
| title_full_unstemmed | Influence of symptom burden on social alienation in lung cancer patients receiving chemotherapy: the chain mediating effect of perceived social support and positive psychological capital |
| title_short | Influence of symptom burden on social alienation in lung cancer patients receiving chemotherapy: the chain mediating effect of perceived social support and positive psychological capital |
| title_sort | influence of symptom burden on social alienation in lung cancer patients receiving chemotherapy the chain mediating effect of perceived social support and positive psychological capital |
| topic | Lung cancer chemotherapy Symptom burden Social alienation Perceived social support Positive psychological capital |
| url | https://doi.org/10.1186/s40359-025-02403-x |
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