Clinical study on compound glycyrrhizin injection wet compress for wounds healing after Hemoporfin-mediated photodynamic therapy for port-wine stains (复方甘草酸苷注射液湿敷治疗鲜红斑痣海姆泊芬光动力术后创面的临床研究)
Objective The aim of this study was to investigate the therapeutic efficacy and safety of wet application of compound glycyrrhizin injection solution on postoperative wounds healing after Hemoporfin-mediated photodynamic therapy (HMME-PDT) for port-wine stains (PWS). Methods A prospective, randomi...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | zho |
| Published: |
Journal of International Translational Medicine Limited
2025-05-01
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| Series: | 中西医结合护理 |
| Subjects: | |
| Online Access: | http://www.zxyjhhl.hk/thesisDetails#10.55111/j.issn2709-1961.20250317002 |
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| Summary: | Objective The aim of this study was to investigate the therapeutic efficacy and safety of wet application of compound glycyrrhizin injection solution on postoperative wounds healing after Hemoporfin-mediated photodynamic therapy (HMME-PDT) for port-wine stains (PWS). Methods A prospective, randomized controlled study design was used to assign patients to trial and control groups in a 1: 1: 1 ratio by computer-generated randomization sequences, and evaluators were blinded (unaware of grouping information) for outcome determination. One hundred and twenty patients with PWS who underwent HMME-PDT from January 2023 to June 2024 were included and matched by age, gender and Mulliken classification 1: 1: 1 into a test group (compound glycyrrhizin wet pack, n=40), control group 1 (ice pack, n=40) and control group 2 (oral ibuprofen, n=40). In the test group, postoperative wet compresses of compound glycyrrhizin injection (40 mg/10 mL saline dilution) were applied to the wounds 2 times/day and continued until healing; in control group 1, ice packs (4°C ice packs with the same frequency and duration) were applied, and in control group 2, oral ibuprofen (400 mg/times, 3 times/day) was administered. Wound healing time, pain score (VAS), inflammatory indexes (CRP, IL-6) and adverse reactions were compared among the three groups. Results The wound healing time of the test group (8. 20 ± 1. 54 days) was significantly shorter than that of control group 1 (9. 80±1. 10 days) and control group 2 (10. 00 ± 1. 30 days) (both P＜0. 01); on postoperative day 3, the VAS score (3. 60 ± 1. 80), CRP (15. 20 ± 4. 30 mg/L), and IL-6 (12. 50 ± 3. 80 pg/ml) of the test group were lower than those of the control group (all P＜0. 01); the rate of adverse reactions in the test group (10. 00%) was significantly lower than that in the control group (25. 00%, 30. 00%, P＜0. 05). Conclusion Wet application of compound glycyrrhizin injection solution can effectively promote wound healing, reduce pain and inflammatory reaction after HMME-PDT for port-wine stains, and has good safety. This method can be used as an effective choice for wound management after photodynamic surgery, and is worthy of promotion in clinical practice. (目的 探讨复方甘草酸苷注射液湿敷对鲜红斑痣(PWS)海姆泊芬光动力(HMME-PDT)术后创面的治疗效果及安全性。方法 采用前瞻性、随机对照研究设计, 通过计算机生成随机序列将患者按1: 1: 1比例分配至试验组和对照组, 评估者采用盲法(对分组信息不知情)进行结果判定。纳入2023年1月—2024年6月接受HMME-PDT的120例PWS患者, 按年龄、性别及Mulliken分级1: 1: 1匹配分为试验组(复方甘草酸苷湿敷, n=40)、对照组1(冰敷, n=40)和对照组2(口服布洛芬, n=40)。试验组术后采用复方甘草酸苷注射液(40 mg/10 mL生理盐水稀释)湿敷创面, 2次/d, 持续至愈合; 对照组1冰敷(4℃冰袋, 同频次及时长), 对照组2口服布洛芬(400 mg/次, 3次/d)。比较三组创面愈合时间、疼痛评分(VAS)、炎症指标［(C反应蛋白(CRP)、白细胞介素-6(IL-6)］及不良反应。结果 试验组创面愈合时间(8. 20±1. 54)d, 短于对照组1的(9. 80±1. 10)d和对照组2的(10. 00±1. 30)d, 差异有统计学意义(P＜0. 01)。术后第3天试验组VAS评分［(3. 60±1. 80)分］、CRP［(15. 20±4. 30) mg/L)］及IL-6［(12. 50±3. 80) pg/mL］均低于对照组(P＜0. 01)。试验组不良反应率(10. 00%), 分别低于对照组1(25. 00%)和对照组2(30. 00%), 差异有统计学意义(P＜0. 05)。结论 复方甘草酸苷注射液湿敷可有效促进鲜红斑痣海姆泊芬光动力术后创面愈合, 减轻疼痛和炎症反应, 且安全性良好。该方法可作为光动力术后创面管理的有效选择, 值得在临床推广应用。) |
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| ISSN: | 2709-1961 |