Immune-mediated necrotizing myositis with hydroxy-3-methyl-glutaryl-coenzyme A reductase antibody positivity in MSA-negative and statin-naive profile
Statin-naïve immune-mediated necrotizing myopathy (IMNM) is a rare disease entity, the diagnosis of which is complicated in the absence of a reliable biomarker. In this context, this case, which is the first one reported from a tertiary care center in South India, is unique. The presence of hydroxy-...
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SAGE Publishing
2023-01-01
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| Series: | Indian Journal of Rheumatology |
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| Online Access: | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2023;volume=18;issue=2;spage=166;epage=169;aulast=Nagamounika |
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| author | Kothapalli Nagamounika Josna Joseph R Hemanth Kumar John Mathew |
| author_facet | Kothapalli Nagamounika Josna Joseph R Hemanth Kumar John Mathew |
| author_sort | Kothapalli Nagamounika |
| collection | DOAJ |
| description | Statin-naïve immune-mediated necrotizing myopathy (IMNM) is a rare disease entity, the diagnosis of which is complicated in the absence of a reliable biomarker. In this context, this case, which is the first one reported from a tertiary care center in South India, is unique. The presence of hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) antibody supplements the clinical diagnosis, specifically in the serological absence of myositis-specific antibodies. A comprehensive diagnostic approach including HMGCR antibody positivity is advisable in IMNM. |
| format | Article |
| id | doaj-art-294b5baac835469fb3b965028f7e2c28 |
| institution | Kabale University |
| issn | 0973-3698 0973-3701 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Indian Journal of Rheumatology |
| spelling | doaj-art-294b5baac835469fb3b965028f7e2c282025-08-20T03:54:47ZengSAGE PublishingIndian Journal of Rheumatology0973-36980973-37012023-01-0118216616910.4103/injr.injr_82_22Immune-mediated necrotizing myositis with hydroxy-3-methyl-glutaryl-coenzyme A reductase antibody positivity in MSA-negative and statin-naive profileKothapalli NagamounikaJosna JosephR Hemanth KumarJohn MathewStatin-naïve immune-mediated necrotizing myopathy (IMNM) is a rare disease entity, the diagnosis of which is complicated in the absence of a reliable biomarker. In this context, this case, which is the first one reported from a tertiary care center in South India, is unique. The presence of hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) antibody supplements the clinical diagnosis, specifically in the serological absence of myositis-specific antibodies. A comprehensive diagnostic approach including HMGCR antibody positivity is advisable in IMNM.http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2023;volume=18;issue=2;spage=166;epage=169;aulast=Nagamounikadiagnosishydroxy-3-methyl-glutaryl-coenzyme a reductase antibodyimmune-mediated necrotizing myopathymyositis |
| spellingShingle | Kothapalli Nagamounika Josna Joseph R Hemanth Kumar John Mathew Immune-mediated necrotizing myositis with hydroxy-3-methyl-glutaryl-coenzyme A reductase antibody positivity in MSA-negative and statin-naive profile Indian Journal of Rheumatology diagnosis hydroxy-3-methyl-glutaryl-coenzyme a reductase antibody immune-mediated necrotizing myopathy myositis |
| title | Immune-mediated necrotizing myositis with hydroxy-3-methyl-glutaryl-coenzyme A reductase antibody positivity in MSA-negative and statin-naive profile |
| title_full | Immune-mediated necrotizing myositis with hydroxy-3-methyl-glutaryl-coenzyme A reductase antibody positivity in MSA-negative and statin-naive profile |
| title_fullStr | Immune-mediated necrotizing myositis with hydroxy-3-methyl-glutaryl-coenzyme A reductase antibody positivity in MSA-negative and statin-naive profile |
| title_full_unstemmed | Immune-mediated necrotizing myositis with hydroxy-3-methyl-glutaryl-coenzyme A reductase antibody positivity in MSA-negative and statin-naive profile |
| title_short | Immune-mediated necrotizing myositis with hydroxy-3-methyl-glutaryl-coenzyme A reductase antibody positivity in MSA-negative and statin-naive profile |
| title_sort | immune mediated necrotizing myositis with hydroxy 3 methyl glutaryl coenzyme a reductase antibody positivity in msa negative and statin naive profile |
| topic | diagnosis hydroxy-3-methyl-glutaryl-coenzyme a reductase antibody immune-mediated necrotizing myopathy myositis |
| url | http://www.indianjrheumatol.com/article.asp?issn=0973-3698;year=2023;volume=18;issue=2;spage=166;epage=169;aulast=Nagamounika |
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