Successfully salvaging a HIV-positive patient with mixed CIDP and meningoencephalitis: a case report
We describe an acquired immunodeficiency syndrome (AIDS) patient who first exhibited chronic inflammatory demyelinating polyneuropathy (CIDP) and subsequently developed meningoencephalitis due to ganciclovir (GCV)-resistant cytomegalovirus (CMV) infection. The patient first presented with peripheral...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1537160/full |
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| author | Wen Wang Jun Yang Xinchao Liu Ying Wen |
| author_facet | Wen Wang Jun Yang Xinchao Liu Ying Wen |
| author_sort | Wen Wang |
| collection | DOAJ |
| description | We describe an acquired immunodeficiency syndrome (AIDS) patient who first exhibited chronic inflammatory demyelinating polyneuropathy (CIDP) and subsequently developed meningoencephalitis due to ganciclovir (GCV)-resistant cytomegalovirus (CMV) infection. The patient first presented with peripheral nervous system (PNS) symptoms, followed by central nervous system (CNS) symptoms. Based on auxiliary examinations, including cerebrospinal fluid (CSF) tests, electromyography (EMG), brain magnetic resonance imaging (MRI) and GCV drug resistance tests, the patient was diagnosed with CIDP and meningoencephalitis due to CSF GCV-resistant CMV. After the combined application of intravenous immunoglobulin treatment, corticosteroid treatment, antiretroviral therapy (ART), and adjusted anti-CMV treatment, the patient achieved persistent relief. This case underscores the importance of considering CMV as a common etiology of neurological disorders in AIDS patients. It also highlights the necessity of prompt drug resistance testing when anti-CMV therapy yields suboptimal responses. |
| format | Article |
| id | doaj-art-2947aebf77c54d6a9e67926af1d693af |
| institution | DOAJ |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-2947aebf77c54d6a9e67926af1d693af2025-08-20T02:57:30ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-03-011210.3389/fmed.2025.15371601537160Successfully salvaging a HIV-positive patient with mixed CIDP and meningoencephalitis: a case reportWen Wang0Jun Yang1Xinchao Liu2Ying Wen3Department of Infectious Diseases, The First Affiliated Hospital of China Medical University, Shenyang, ChinaNeurology Department, The First Affiliated Hospital of China Medical University, Shenyang, ChinaInfectious Disease Department, Peking Union Medical College Hospital, Beijing, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of China Medical University, Shenyang, ChinaWe describe an acquired immunodeficiency syndrome (AIDS) patient who first exhibited chronic inflammatory demyelinating polyneuropathy (CIDP) and subsequently developed meningoencephalitis due to ganciclovir (GCV)-resistant cytomegalovirus (CMV) infection. The patient first presented with peripheral nervous system (PNS) symptoms, followed by central nervous system (CNS) symptoms. Based on auxiliary examinations, including cerebrospinal fluid (CSF) tests, electromyography (EMG), brain magnetic resonance imaging (MRI) and GCV drug resistance tests, the patient was diagnosed with CIDP and meningoencephalitis due to CSF GCV-resistant CMV. After the combined application of intravenous immunoglobulin treatment, corticosteroid treatment, antiretroviral therapy (ART), and adjusted anti-CMV treatment, the patient achieved persistent relief. This case underscores the importance of considering CMV as a common etiology of neurological disorders in AIDS patients. It also highlights the necessity of prompt drug resistance testing when anti-CMV therapy yields suboptimal responses.https://www.frontiersin.org/articles/10.3389/fmed.2025.1537160/fullcytomegalovirusmeningoencephalitischronic inflammatory demyelinating polyradiculoneuropathyganciclovir resistanceacquired immunodeficiency syndrome |
| spellingShingle | Wen Wang Jun Yang Xinchao Liu Ying Wen Successfully salvaging a HIV-positive patient with mixed CIDP and meningoencephalitis: a case report Frontiers in Medicine cytomegalovirus meningoencephalitis chronic inflammatory demyelinating polyradiculoneuropathy ganciclovir resistance acquired immunodeficiency syndrome |
| title | Successfully salvaging a HIV-positive patient with mixed CIDP and meningoencephalitis: a case report |
| title_full | Successfully salvaging a HIV-positive patient with mixed CIDP and meningoencephalitis: a case report |
| title_fullStr | Successfully salvaging a HIV-positive patient with mixed CIDP and meningoencephalitis: a case report |
| title_full_unstemmed | Successfully salvaging a HIV-positive patient with mixed CIDP and meningoencephalitis: a case report |
| title_short | Successfully salvaging a HIV-positive patient with mixed CIDP and meningoencephalitis: a case report |
| title_sort | successfully salvaging a hiv positive patient with mixed cidp and meningoencephalitis a case report |
| topic | cytomegalovirus meningoencephalitis chronic inflammatory demyelinating polyradiculoneuropathy ganciclovir resistance acquired immunodeficiency syndrome |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1537160/full |
| work_keys_str_mv | AT wenwang successfullysalvagingahivpositivepatientwithmixedcidpandmeningoencephalitisacasereport AT junyang successfullysalvagingahivpositivepatientwithmixedcidpandmeningoencephalitisacasereport AT xinchaoliu successfullysalvagingahivpositivepatientwithmixedcidpandmeningoencephalitisacasereport AT yingwen successfullysalvagingahivpositivepatientwithmixedcidpandmeningoencephalitisacasereport |