The association of 5-HT2A, 5-HTT, and LEPR polymorphisms with obstructive sleep apnea syndrome: a systematic review and meta-analysis.
<h4>Objective</h4>A consensus has not been reached regarding the association of several different gene polymorphisms and susceptibility to obstructive sleep apnea syndrome (OSAS). We performed a meta-analysis to better evaluate the associations between 5-HT2A, 5-HTT, and LEPR polymorphis...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0095856 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850076458706272256 |
|---|---|
| author | Baodong Qin Zhen Sun Yan Liang Zaixing Yang Renqian Zhong |
| author_facet | Baodong Qin Zhen Sun Yan Liang Zaixing Yang Renqian Zhong |
| author_sort | Baodong Qin |
| collection | DOAJ |
| description | <h4>Objective</h4>A consensus has not been reached regarding the association of several different gene polymorphisms and susceptibility to obstructive sleep apnea syndrome (OSAS). We performed a meta-analysis to better evaluate the associations between 5-HT2A, 5-HTT, and LEPR polymorphisms, and OSAS.<h4>Method</h4>5-HT2A, 5-HTT, and LEPR polymorphisms and OSAS were identified in PubMed and EMBASE. The pooled odd rates (ORs) with 95%CIs were estimated using a fixed-effect or random-effect models. The associations between these polymorphisms and OSAS risk were assessed using dominant, recessive and additive models.<h4>Results</h4>Twelve publications were included in this study. The -1438 "A" allele of 5-HT2A was identified as a candidate genetic risk factor for OSAS (OR: 2.33, 95%CI 1.49-3.66). Individuals carrying the -1438 "G" allele had a nearly 70% reduced risk of OSAS when compared with AA homozygotes (OR: 0.30, 95%CI 0.23-0.40). There was no significant association between 5-HT2A 102C/T and OSAS risk, using any model. The "S" allele of 5-HTTLPR conferred protection against OSAS (OR: 0.80, 95%CI 0.67-0.95), while the "10" allele of 5-HTTVNTR contributed to the risk of OSAS (OR: 2.08, 95%CI: 1.58-2.73). The "GG" genotype of LEPR was associated with a reduced risk of OSAS (OR: 0.39, 95%CI 0.17-0.88).<h4>Conclusion</h4>The meta-analysis demonstrated that 5-HTR-1438 "A" and 5-HTTVNTR "10" alleles were significantly associated with OSAS. The "S" allele of 5-HTTLPR and the "GG" genotype of LEPR conferred protection against OSAS. Further studies, such as Genome-Wide Association study (GWAS), should be conducted in a large cohort of OSAS patients to confirm our findings. |
| format | Article |
| id | doaj-art-293ed847ecfd4580a0b89b282e4a01fd |
| institution | DOAJ |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-293ed847ecfd4580a0b89b282e4a01fd2025-08-20T02:46:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9585610.1371/journal.pone.0095856The association of 5-HT2A, 5-HTT, and LEPR polymorphisms with obstructive sleep apnea syndrome: a systematic review and meta-analysis.Baodong QinZhen SunYan LiangZaixing YangRenqian Zhong<h4>Objective</h4>A consensus has not been reached regarding the association of several different gene polymorphisms and susceptibility to obstructive sleep apnea syndrome (OSAS). We performed a meta-analysis to better evaluate the associations between 5-HT2A, 5-HTT, and LEPR polymorphisms, and OSAS.<h4>Method</h4>5-HT2A, 5-HTT, and LEPR polymorphisms and OSAS were identified in PubMed and EMBASE. The pooled odd rates (ORs) with 95%CIs were estimated using a fixed-effect or random-effect models. The associations between these polymorphisms and OSAS risk were assessed using dominant, recessive and additive models.<h4>Results</h4>Twelve publications were included in this study. The -1438 "A" allele of 5-HT2A was identified as a candidate genetic risk factor for OSAS (OR: 2.33, 95%CI 1.49-3.66). Individuals carrying the -1438 "G" allele had a nearly 70% reduced risk of OSAS when compared with AA homozygotes (OR: 0.30, 95%CI 0.23-0.40). There was no significant association between 5-HT2A 102C/T and OSAS risk, using any model. The "S" allele of 5-HTTLPR conferred protection against OSAS (OR: 0.80, 95%CI 0.67-0.95), while the "10" allele of 5-HTTVNTR contributed to the risk of OSAS (OR: 2.08, 95%CI: 1.58-2.73). The "GG" genotype of LEPR was associated with a reduced risk of OSAS (OR: 0.39, 95%CI 0.17-0.88).<h4>Conclusion</h4>The meta-analysis demonstrated that 5-HTR-1438 "A" and 5-HTTVNTR "10" alleles were significantly associated with OSAS. The "S" allele of 5-HTTLPR and the "GG" genotype of LEPR conferred protection against OSAS. Further studies, such as Genome-Wide Association study (GWAS), should be conducted in a large cohort of OSAS patients to confirm our findings.https://doi.org/10.1371/journal.pone.0095856 |
| spellingShingle | Baodong Qin Zhen Sun Yan Liang Zaixing Yang Renqian Zhong The association of 5-HT2A, 5-HTT, and LEPR polymorphisms with obstructive sleep apnea syndrome: a systematic review and meta-analysis. PLoS ONE |
| title | The association of 5-HT2A, 5-HTT, and LEPR polymorphisms with obstructive sleep apnea syndrome: a systematic review and meta-analysis. |
| title_full | The association of 5-HT2A, 5-HTT, and LEPR polymorphisms with obstructive sleep apnea syndrome: a systematic review and meta-analysis. |
| title_fullStr | The association of 5-HT2A, 5-HTT, and LEPR polymorphisms with obstructive sleep apnea syndrome: a systematic review and meta-analysis. |
| title_full_unstemmed | The association of 5-HT2A, 5-HTT, and LEPR polymorphisms with obstructive sleep apnea syndrome: a systematic review and meta-analysis. |
| title_short | The association of 5-HT2A, 5-HTT, and LEPR polymorphisms with obstructive sleep apnea syndrome: a systematic review and meta-analysis. |
| title_sort | association of 5 ht2a 5 htt and lepr polymorphisms with obstructive sleep apnea syndrome a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0095856 |
| work_keys_str_mv | AT baodongqin theassociationof5ht2a5httandleprpolymorphismswithobstructivesleepapneasyndromeasystematicreviewandmetaanalysis AT zhensun theassociationof5ht2a5httandleprpolymorphismswithobstructivesleepapneasyndromeasystematicreviewandmetaanalysis AT yanliang theassociationof5ht2a5httandleprpolymorphismswithobstructivesleepapneasyndromeasystematicreviewandmetaanalysis AT zaixingyang theassociationof5ht2a5httandleprpolymorphismswithobstructivesleepapneasyndromeasystematicreviewandmetaanalysis AT renqianzhong theassociationof5ht2a5httandleprpolymorphismswithobstructivesleepapneasyndromeasystematicreviewandmetaanalysis AT baodongqin associationof5ht2a5httandleprpolymorphismswithobstructivesleepapneasyndromeasystematicreviewandmetaanalysis AT zhensun associationof5ht2a5httandleprpolymorphismswithobstructivesleepapneasyndromeasystematicreviewandmetaanalysis AT yanliang associationof5ht2a5httandleprpolymorphismswithobstructivesleepapneasyndromeasystematicreviewandmetaanalysis AT zaixingyang associationof5ht2a5httandleprpolymorphismswithobstructivesleepapneasyndromeasystematicreviewandmetaanalysis AT renqianzhong associationof5ht2a5httandleprpolymorphismswithobstructivesleepapneasyndromeasystematicreviewandmetaanalysis |