Statin and fibrate associed myopathy: study of eight patients
Lipid-lowering drugs have been occasionally associated with neuromuscular symptoms and muscle biopsy changes. We reported the clinical course and the muscle biopsy in eight patients with hyperlipoproteinemia, treated with lipid -lowering drugs (statins/fibrates). Five patients had myalgias while; in...
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| Language: | English |
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Thieme Revinter Publicações
2004-06-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000200013&tlng=en |
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| author | Alzira A. Siqueira Carvalho Ürsula Waleska Poti Lima Raul Alberto Valiente |
| author_facet | Alzira A. Siqueira Carvalho Ürsula Waleska Poti Lima Raul Alberto Valiente |
| author_sort | Alzira A. Siqueira Carvalho |
| collection | DOAJ |
| description | Lipid-lowering drugs have been occasionally associated with neuromuscular symptoms and muscle biopsy changes. We reported the clinical course and the muscle biopsy in eight patients with hyperlipoproteinemia, treated with lipid -lowering drugs (statins/fibrates). Five patients had myalgias while; in two cases there was proximal muscle weakness. All patients became asymptomatic after the withdrawal of the drug, although creatine kinase remained elevated. We performed muscle biopsy in six cases from three months to two years after suspension of the drug. We found variation in fibers diameters in all cases, with necrosis of fibers in five cases, inflammatory infiltration in one case, the presence of vacuolated fiber in one patient and ragged-red fibers in three subjects. We concluded that although the muscle biopsy findings were not specific, the prolonged use of statins and or fibrates might induce a chronic myopathy even in the absence of symptoms. |
| format | Article |
| id | doaj-art-293cef21edf44d898d097048ef94c25a |
| institution | OA Journals |
| issn | 1678-4227 |
| language | English |
| publishDate | 2004-06-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-293cef21edf44d898d097048ef94c25a2025-08-20T02:01:39ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272004-06-01622a25726110.1590/S0004-282X2004000200013Statin and fibrate associed myopathy: study of eight patientsAlzira A. Siqueira Carvalho0Ürsula Waleska Poti Lima1Raul Alberto Valiente2Hospital de Santa MarcelinaHospital de Santa MarcelinaHospital de Santa MarcelinaLipid-lowering drugs have been occasionally associated with neuromuscular symptoms and muscle biopsy changes. We reported the clinical course and the muscle biopsy in eight patients with hyperlipoproteinemia, treated with lipid -lowering drugs (statins/fibrates). Five patients had myalgias while; in two cases there was proximal muscle weakness. All patients became asymptomatic after the withdrawal of the drug, although creatine kinase remained elevated. We performed muscle biopsy in six cases from three months to two years after suspension of the drug. We found variation in fibers diameters in all cases, with necrosis of fibers in five cases, inflammatory infiltration in one case, the presence of vacuolated fiber in one patient and ragged-red fibers in three subjects. We concluded that although the muscle biopsy findings were not specific, the prolonged use of statins and or fibrates might induce a chronic myopathy even in the absence of symptoms.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000200013&tlng=enstatinsfibratesmyopathymuscle biopsycreatine kinase |
| spellingShingle | Alzira A. Siqueira Carvalho Ürsula Waleska Poti Lima Raul Alberto Valiente Statin and fibrate associed myopathy: study of eight patients Arquivos de Neuro-Psiquiatria statins fibrates myopathy muscle biopsy creatine kinase |
| title | Statin and fibrate associed myopathy: study of eight patients |
| title_full | Statin and fibrate associed myopathy: study of eight patients |
| title_fullStr | Statin and fibrate associed myopathy: study of eight patients |
| title_full_unstemmed | Statin and fibrate associed myopathy: study of eight patients |
| title_short | Statin and fibrate associed myopathy: study of eight patients |
| title_sort | statin and fibrate associed myopathy study of eight patients |
| topic | statins fibrates myopathy muscle biopsy creatine kinase |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2004000200013&tlng=en |
| work_keys_str_mv | AT alziraasiqueiracarvalho statinandfibrateassociedmyopathystudyofeightpatients AT ursulawaleskapotilima statinandfibrateassociedmyopathystudyofeightpatients AT raulalbertovaliente statinandfibrateassociedmyopathystudyofeightpatients |