Systematic Administration of B Vitamins Alleviates Diabetic Pain and Inhibits Associated Expression of P2X3 and TRPV1 in Dorsal Root Ganglion Neurons and Proinflammatory Cytokines in Spinal Cord in Rats
Background. Treatment of diabetic neuropathic pain (DNP) continues to be a major challenge, and underlying mechanisms of DNP remain elusive. We investigated treatment effects of B vitamins on DPN- and DNP-associated alterations of neurochemical signaling in the nociceptive dorsal root ganglion (DRG)...
Saved in:
Main Authors: | Duan-Duan He, Yu Gao, Shan Wang, Zhong Xie, Xue-Jun Song |
---|---|
Format: | Article |
Language: | English |
Published: |
Wiley
2020-01-01
|
Series: | Pain Research and Management |
Online Access: | http://dx.doi.org/10.1155/2020/3740162 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Radiotherapy Suppresses Bone Cancer Pain through Inhibiting Activation of cAMP Signaling in Rat Dorsal Root Ganglion and Spinal Cord
by: Guiqin Zhu, et al.
Published: (2016-01-01) -
Hyperexcitability in Spinal WDR Neurons following Experimental Disc Herniation Is Associated with Upregulation of Fractalkine and Its Receptor in Nucleus Pulposus and the Dorsal Root Ganglion
by: Daniel Pitz Jacobsen, et al.
Published: (2016-01-01) -
Modulation of Spinal GABAergic Inhibition and Mechanical Hypersensitivity following Chronic Compression of Dorsal Root Ganglion in the Rat
by: Moon Chul Lee, et al.
Published: (2015-01-01) -
The Wnt/β-Catenin Pathway Regulated Cytokines for Pathological Neuropathic Pain in Chronic Compression of Dorsal Root Ganglion Model
by: Ye Zhang, et al.
Published: (2021-01-01) -
CtBP1 is essential for epigenetic silencing of μ-opioid receptor genes in the dorsal root ganglion in spinal nerve ligation-induced neuropathic pain
by: Cheng-Yuan Lai, et al.
Published: (2025-01-01)