THE EFFECT OF PARACETAMOL AND CODEINE ANALGESIC COMBINATION ON SERUM GLUTAMIC OXALOACETATE TRANSAMINASE LEVELS IN MALE WISTAR RATS
Introduction : Paracetamol is an effective analgesic to relieve mild to moderate pain when it is used in therapeutic doses. Codeine is an opioid analgesic to relieve moderate to severe pain. Both are metabolized in the liver and have different mechanisms in the treatment of pain. The use of paraceta...
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Faculty of Medicine, Universitas Diponegoro
2020-03-01
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| Series: | Jurnal Kedokteran Diponegoro |
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| Online Access: | https://ejournal3.undip.ac.id/index.php/medico/article/view/27080 |
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| author | Rona Ayu Hanifah Farah Hendara Ningrum Erwin Kresnoadi Satrio Adi Wicaksono |
| author_facet | Rona Ayu Hanifah Farah Hendara Ningrum Erwin Kresnoadi Satrio Adi Wicaksono |
| author_sort | Rona Ayu Hanifah |
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| description | Introduction : Paracetamol is an effective analgesic to relieve mild to moderate pain when it is used in therapeutic doses. Codeine is an opioid analgesic to relieve moderate to severe pain. Both are metabolized in the liver and have different mechanisms in the treatment of pain. The use of paracetamol and codeine as monotherapy has been extensive, but research on the effectiveness of these drugs in combination is still limited, especially about its effect in liver damage. This study was to investigate the effect of paracetamol and codeine analgesic combination Serum Glutamic Oxaloacetate Transaminase levels in male Wistar rats. Method : This was an experimental study using Post-Test Only Control Group Design. The samples were 24 male wistar rats randomized into 4 groups; group I (control group, without treatment), group II receiving paracetamol 32 mg/kgBB, group III receiving codeine 1,9 mg/kgBB, and group IV receiving combination of paracetamol 32 mg/kgBB and codeine 1,9 mg/kgBB. Drugs were administered through oral gastric instillation 4 times a day for 28 days. Blood samples were collected at the 29th day through retroorbital vessel to measure the SGOT levels. The data was analysed using One-Way ANOVA test and Post-Hoc test. Results : The results of this research were obtained from statistical tests where there was no significant increase of the levels of Serum Glutamic Oxaloacetate Transaminase of Wistar rats which received a combination of paracetamol and codeine in the control group (p = 0.005). While in the other group there was not significant differences of the levels of Serum Glutamic Oxaloacetate Transaminase. Conclusion : There is no significant difference of Serum Glutamic Oxaloacetate Transaminase levels between the administration of paracetamol and codeine combination compared to the control group.
Keywords : Paracetamol, codeine, paracetamol and codeine combination, SGOT levels, pain |
| format | Article |
| id | doaj-art-293b0f3d24ac4f03b1a259c2812f92d8 |
| institution | Kabale University |
| issn | 2540-8844 |
| language | English |
| publishDate | 2020-03-01 |
| publisher | Faculty of Medicine, Universitas Diponegoro |
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| series | Jurnal Kedokteran Diponegoro |
| spelling | doaj-art-293b0f3d24ac4f03b1a259c2812f92d82025-08-20T03:30:24ZengFaculty of Medicine, Universitas DiponegoroJurnal Kedokteran Diponegoro2540-88442020-03-019214815310.14710/dmj.v9i2.2708024427THE EFFECT OF PARACETAMOL AND CODEINE ANALGESIC COMBINATION ON SERUM GLUTAMIC OXALOACETATE TRANSAMINASE LEVELS IN MALE WISTAR RATSRona Ayu HanifahFarah Hendara NingrumErwin KresnoadiSatrio Adi WicaksonoIntroduction : Paracetamol is an effective analgesic to relieve mild to moderate pain when it is used in therapeutic doses. Codeine is an opioid analgesic to relieve moderate to severe pain. Both are metabolized in the liver and have different mechanisms in the treatment of pain. The use of paracetamol and codeine as monotherapy has been extensive, but research on the effectiveness of these drugs in combination is still limited, especially about its effect in liver damage. This study was to investigate the effect of paracetamol and codeine analgesic combination Serum Glutamic Oxaloacetate Transaminase levels in male Wistar rats. Method : This was an experimental study using Post-Test Only Control Group Design. The samples were 24 male wistar rats randomized into 4 groups; group I (control group, without treatment), group II receiving paracetamol 32 mg/kgBB, group III receiving codeine 1,9 mg/kgBB, and group IV receiving combination of paracetamol 32 mg/kgBB and codeine 1,9 mg/kgBB. Drugs were administered through oral gastric instillation 4 times a day for 28 days. Blood samples were collected at the 29th day through retroorbital vessel to measure the SGOT levels. The data was analysed using One-Way ANOVA test and Post-Hoc test. Results : The results of this research were obtained from statistical tests where there was no significant increase of the levels of Serum Glutamic Oxaloacetate Transaminase of Wistar rats which received a combination of paracetamol and codeine in the control group (p = 0.005). While in the other group there was not significant differences of the levels of Serum Glutamic Oxaloacetate Transaminase. Conclusion : There is no significant difference of Serum Glutamic Oxaloacetate Transaminase levels between the administration of paracetamol and codeine combination compared to the control group. Keywords : Paracetamol, codeine, paracetamol and codeine combination, SGOT levels, painhttps://ejournal3.undip.ac.id/index.php/medico/article/view/27080paracetamol, codeine, paracetamol and codeine combination, sgot levels, pain |
| spellingShingle | Rona Ayu Hanifah Farah Hendara Ningrum Erwin Kresnoadi Satrio Adi Wicaksono THE EFFECT OF PARACETAMOL AND CODEINE ANALGESIC COMBINATION ON SERUM GLUTAMIC OXALOACETATE TRANSAMINASE LEVELS IN MALE WISTAR RATS Jurnal Kedokteran Diponegoro paracetamol, codeine, paracetamol and codeine combination, sgot levels, pain |
| title | THE EFFECT OF PARACETAMOL AND CODEINE ANALGESIC COMBINATION ON SERUM GLUTAMIC OXALOACETATE TRANSAMINASE LEVELS IN MALE WISTAR RATS |
| title_full | THE EFFECT OF PARACETAMOL AND CODEINE ANALGESIC COMBINATION ON SERUM GLUTAMIC OXALOACETATE TRANSAMINASE LEVELS IN MALE WISTAR RATS |
| title_fullStr | THE EFFECT OF PARACETAMOL AND CODEINE ANALGESIC COMBINATION ON SERUM GLUTAMIC OXALOACETATE TRANSAMINASE LEVELS IN MALE WISTAR RATS |
| title_full_unstemmed | THE EFFECT OF PARACETAMOL AND CODEINE ANALGESIC COMBINATION ON SERUM GLUTAMIC OXALOACETATE TRANSAMINASE LEVELS IN MALE WISTAR RATS |
| title_short | THE EFFECT OF PARACETAMOL AND CODEINE ANALGESIC COMBINATION ON SERUM GLUTAMIC OXALOACETATE TRANSAMINASE LEVELS IN MALE WISTAR RATS |
| title_sort | effect of paracetamol and codeine analgesic combination on serum glutamic oxaloacetate transaminase levels in male wistar rats |
| topic | paracetamol, codeine, paracetamol and codeine combination, sgot levels, pain |
| url | https://ejournal3.undip.ac.id/index.php/medico/article/view/27080 |
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