OUTBREAK OF BURKHOLDERIA CEPACIA INFECTION: A SYSTEMATIC STUDY IN A HEMATOLOGY-ONCOLOGY UNIT OF A TERTIARY CARE HOSPITAL FROM EASTERN INDIA.
Background: Burkholderia cepacia, an aerobic gram-negative bacillus, is a frequent colonizer of fluids used in the hospital ward. It poses little risk of infection to healthy people; however it is a known important opportunistic pathogen causing morbidity and mortality due to its intrinsic resistanc...
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PAGEPress Publications
2018-09-01
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| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
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| Online Access: | https://www.mjhid.org/index.php/mjhid/article/view/3380 |
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| author | Shuvra Neel Baul Rajib De PRAKAS KUMAR MANDAL Swagnik Roy Tuphan Kanti Dolai Prantar Chakrabarti |
| author_facet | Shuvra Neel Baul Rajib De PRAKAS KUMAR MANDAL Swagnik Roy Tuphan Kanti Dolai Prantar Chakrabarti |
| author_sort | Shuvra Neel Baul |
| collection | DOAJ |
| description | Background: Burkholderia cepacia, an aerobic gram-negative bacillus, is a frequent colonizer of fluids used in the hospital ward. It poses little risk of infection to healthy people; however it is a known important opportunistic pathogen causing morbidity and mortality due to its intrinsic resistance to most of the antibiotics in hospitalized patients. Small hospital outbreaks are frequent. B. cepacia may occur as an opportunistic infection in hemato-oncology patients. Here we present an outbreak of Burkholderia cepacia infection in hematology ward of our institute.
Methods: Febrile episodes as defined by IDSA guideline, 2010 were followed, and blood for culture and sensitivity was sent in all the events. The culture was done by an automated method using Bactalert 3d Biomeriux & sensitivity pattern by Microscan Siemens method and subsequently detected by PCR based method.
Results: During September 2016 to February 2017 (six months), a total of 498 blood cultures were sent during febrile episodes. Out of which 60 (12%) came out to be positive for different microorganisms. Out of all positive cultures, Burkholderia cepacia was detected in 29 (48%) patients, which reduced drastically following the change in antibiotic administration practice. All isolates showed sensitivity to pipercillin+tazobactum, cefoperazone+sulbactum, fluoroquinolones, cotrimoxazole and carbapenems and resistance to polymyxin B and colistin. With timely intervention by appropriate intravenous antibiotics as per culture sensitivity result and change in antibiotic preparation practice, overall mortality was low 1 (4%) out of 29 culture positive episodes. |
| format | Article |
| id | doaj-art-293735f640be44e99b78d72c3cc445ac |
| institution | Kabale University |
| issn | 2035-3006 |
| language | English |
| publishDate | 2018-09-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | Mediterranean Journal of Hematology and Infectious Diseases |
| spelling | doaj-art-293735f640be44e99b78d72c3cc445ac2024-12-02T09:47:05ZengPAGEPress PublicationsMediterranean Journal of Hematology and Infectious Diseases2035-30062018-09-01101e2018051e201805110.4084/mjhid.2018.0511774OUTBREAK OF BURKHOLDERIA CEPACIA INFECTION: A SYSTEMATIC STUDY IN A HEMATOLOGY-ONCOLOGY UNIT OF A TERTIARY CARE HOSPITAL FROM EASTERN INDIA.Shuvra Neel Baul0Rajib De1PRAKAS KUMAR MANDAL2Swagnik Roy3Tuphan Kanti Dolai4Prantar Chakrabarti5Department of Haematology, NRS Medical College, KolkataDepartment of Haematology, NRS Medical College, KolkataDEPARTMENT OF HEMATOLOGY, N.R.S. MEDICAL COLLEGE, 138, A.J.C. BOSE ROAD; KOLKATA-700014.Department of Microbiology, KPC Medical College and Hospital; Jadavpur, KolkataDepartment of Haematology, NRS Medical College, KolkataDepartment of Haematology, NRS Medical College, KolkataBackground: Burkholderia cepacia, an aerobic gram-negative bacillus, is a frequent colonizer of fluids used in the hospital ward. It poses little risk of infection to healthy people; however it is a known important opportunistic pathogen causing morbidity and mortality due to its intrinsic resistance to most of the antibiotics in hospitalized patients. Small hospital outbreaks are frequent. B. cepacia may occur as an opportunistic infection in hemato-oncology patients. Here we present an outbreak of Burkholderia cepacia infection in hematology ward of our institute. Methods: Febrile episodes as defined by IDSA guideline, 2010 were followed, and blood for culture and sensitivity was sent in all the events. The culture was done by an automated method using Bactalert 3d Biomeriux & sensitivity pattern by Microscan Siemens method and subsequently detected by PCR based method. Results: During September 2016 to February 2017 (six months), a total of 498 blood cultures were sent during febrile episodes. Out of which 60 (12%) came out to be positive for different microorganisms. Out of all positive cultures, Burkholderia cepacia was detected in 29 (48%) patients, which reduced drastically following the change in antibiotic administration practice. All isolates showed sensitivity to pipercillin+tazobactum, cefoperazone+sulbactum, fluoroquinolones, cotrimoxazole and carbapenems and resistance to polymyxin B and colistin. With timely intervention by appropriate intravenous antibiotics as per culture sensitivity result and change in antibiotic preparation practice, overall mortality was low 1 (4%) out of 29 culture positive episodes.https://www.mjhid.org/index.php/mjhid/article/view/3380Burkholderia cepacia, febrile neutropenia, antibiotic preparation practice |
| spellingShingle | Shuvra Neel Baul Rajib De PRAKAS KUMAR MANDAL Swagnik Roy Tuphan Kanti Dolai Prantar Chakrabarti OUTBREAK OF BURKHOLDERIA CEPACIA INFECTION: A SYSTEMATIC STUDY IN A HEMATOLOGY-ONCOLOGY UNIT OF A TERTIARY CARE HOSPITAL FROM EASTERN INDIA. Mediterranean Journal of Hematology and Infectious Diseases Burkholderia cepacia, febrile neutropenia, antibiotic preparation practice |
| title | OUTBREAK OF BURKHOLDERIA CEPACIA INFECTION: A SYSTEMATIC STUDY IN A HEMATOLOGY-ONCOLOGY UNIT OF A TERTIARY CARE HOSPITAL FROM EASTERN INDIA. |
| title_full | OUTBREAK OF BURKHOLDERIA CEPACIA INFECTION: A SYSTEMATIC STUDY IN A HEMATOLOGY-ONCOLOGY UNIT OF A TERTIARY CARE HOSPITAL FROM EASTERN INDIA. |
| title_fullStr | OUTBREAK OF BURKHOLDERIA CEPACIA INFECTION: A SYSTEMATIC STUDY IN A HEMATOLOGY-ONCOLOGY UNIT OF A TERTIARY CARE HOSPITAL FROM EASTERN INDIA. |
| title_full_unstemmed | OUTBREAK OF BURKHOLDERIA CEPACIA INFECTION: A SYSTEMATIC STUDY IN A HEMATOLOGY-ONCOLOGY UNIT OF A TERTIARY CARE HOSPITAL FROM EASTERN INDIA. |
| title_short | OUTBREAK OF BURKHOLDERIA CEPACIA INFECTION: A SYSTEMATIC STUDY IN A HEMATOLOGY-ONCOLOGY UNIT OF A TERTIARY CARE HOSPITAL FROM EASTERN INDIA. |
| title_sort | outbreak of burkholderia cepacia infection a systematic study in a hematology oncology unit of a tertiary care hospital from eastern india |
| topic | Burkholderia cepacia, febrile neutropenia, antibiotic preparation practice |
| url | https://www.mjhid.org/index.php/mjhid/article/view/3380 |
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