Non-Alcoholic Fatty Liver Disease and the Risk of Liver Fibrosis in Chronic Hepatitis B Patients
Introduction. Prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing throughout the world due to sedentary lifestyle and dietary habit, including in patients with chronic hepatitis B (CHB). In several studies, advanced of liver disease were more likely observed among those CHB pat...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Indonesian |
| Published: |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia
2023-09-01
|
| Series: | Jurnal Penyakit Dalam Indonesia |
| Subjects: | |
| Online Access: | https://scholarhub.ui.ac.id/jpdi/vol10/iss3/2/ |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850160788986134528 |
|---|---|
| author | Andri Sanityoso Sulaiman Irsan Hasan Cosmas Rinaldi A. Lesmana Juferdy Kurniawan Chyntia Olivia M. Jasirwan Saut Horas H. Nababan Kemal Fariz Kalista Gita Aprilicia Rino Alvani Gani |
| author_facet | Andri Sanityoso Sulaiman Irsan Hasan Cosmas Rinaldi A. Lesmana Juferdy Kurniawan Chyntia Olivia M. Jasirwan Saut Horas H. Nababan Kemal Fariz Kalista Gita Aprilicia Rino Alvani Gani |
| author_sort | Andri Sanityoso Sulaiman |
| collection | DOAJ |
| description | Introduction. Prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing throughout the world due to sedentary
lifestyle and dietary habit, including in patients with chronic hepatitis B (CHB). In several studies, advanced of liver disease
were more likely observed among those CHB patients with NAFLD. NAFLD might increase the risk of liver disease progression
in CHB patients, but prior investigations were still limited. This study aimed to determine the association between NAFLD and
risk of liver fibrosis in CHB patients.
Methods. All patients with positive serum hepatitis B surface antigen in the Hepatobilier Data Registry, Cipto Mangunkusumo
Hospital, were included in this study. Based on abdominal ultrasonography, patients were divided into two group (group
I: non-NAFLD – hepatitis B patients vs. group II: NAFLD – hepatitis B patients). Data demographic and clinical examination
were collected. Significant liver fibrosis was defined as stage liver fibrosis above 7 kPa (≥ F2). Logistic regression was used to
identify NAFLD as risk factor for significant fibrosis. Variables were expressed as prevalence odd ratio (POR) with 95% CI. P
values <0.05 were considered statistically significant.
Results. Among 130 hepatitis B patients, 45 patients (34.6%) were diagnosed with NAFLD. Of 45 patients in group II, 36
patients (80%) had significant liver fibrosis. It was observed that a higher percentage of patients in group II were HBeAg
negative compared to those in group I (66.7% vs. 35.9%; p=0.038). Furthermore, group II also displayed higher levels of liver
stiffness compared to group I (12.22 (8.6 kPa) vs. 8.57 (7.8 kPa); p 0.016). In multivariate analysis, NAFLD was significantly associated with significant liver fibrosis (POR: 5.87; CI95%: 2.48 – 13.86; p < 0.001) after adjusted with HBeAg status.
Conclusion. NAFLD associated with the higher risk of liver fibrosis in patients with hepatitis B. Modification of lifestyle and
potential therapeutic intervention may help in reducing the progression of liver fibrosis. |
| format | Article |
| id | doaj-art-29310b7c86cf40dcb8160c0b865bd596 |
| institution | OA Journals |
| issn | 2406-8969 2549-0621 |
| language | Indonesian |
| publishDate | 2023-09-01 |
| publisher | Department of Internal Medicine, Faculty of Medicine Universitas Indonesia |
| record_format | Article |
| series | Jurnal Penyakit Dalam Indonesia |
| spelling | doaj-art-29310b7c86cf40dcb8160c0b865bd5962025-08-20T02:23:04ZindDepartment of Internal Medicine, Faculty of Medicine Universitas IndonesiaJurnal Penyakit Dalam Indonesia2406-89692549-06212023-09-01103118122https://doi.org/10.7454/jpdi.v10i3.1456Non-Alcoholic Fatty Liver Disease and the Risk of Liver Fibrosis in Chronic Hepatitis B PatientsAndri Sanityoso Sulaiman0 Irsan Hasan1Cosmas Rinaldi A. Lesmana2Juferdy Kurniawan3 Chyntia Olivia M. Jasirwan4Saut Horas H. Nababan5Kemal Fariz Kalista6Gita Aprilicia7Rino Alvani Gani8Divisi Hepatobilier, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, JakartaDivisi Hepatobilier, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, JakartaDivisi Hepatobilier, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, JakartaDivisi Hepatobilier, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, JakartaDivisi Hepatobilier, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, JakartaDivisi Hepatobilier, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, JakartaDivisi Hepatobilier, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, JakartaDivisi Hepatobilier, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, JakartaDivisi Hepatobilier, Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Universitas Indonesia/RSUPN Dr. Cipto Mangunkusumo, JakartaIntroduction. Prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing throughout the world due to sedentary lifestyle and dietary habit, including in patients with chronic hepatitis B (CHB). In several studies, advanced of liver disease were more likely observed among those CHB patients with NAFLD. NAFLD might increase the risk of liver disease progression in CHB patients, but prior investigations were still limited. This study aimed to determine the association between NAFLD and risk of liver fibrosis in CHB patients. Methods. All patients with positive serum hepatitis B surface antigen in the Hepatobilier Data Registry, Cipto Mangunkusumo Hospital, were included in this study. Based on abdominal ultrasonography, patients were divided into two group (group I: non-NAFLD – hepatitis B patients vs. group II: NAFLD – hepatitis B patients). Data demographic and clinical examination were collected. Significant liver fibrosis was defined as stage liver fibrosis above 7 kPa (≥ F2). Logistic regression was used to identify NAFLD as risk factor for significant fibrosis. Variables were expressed as prevalence odd ratio (POR) with 95% CI. P values <0.05 were considered statistically significant. Results. Among 130 hepatitis B patients, 45 patients (34.6%) were diagnosed with NAFLD. Of 45 patients in group II, 36 patients (80%) had significant liver fibrosis. It was observed that a higher percentage of patients in group II were HBeAg negative compared to those in group I (66.7% vs. 35.9%; p=0.038). Furthermore, group II also displayed higher levels of liver stiffness compared to group I (12.22 (8.6 kPa) vs. 8.57 (7.8 kPa); p 0.016). In multivariate analysis, NAFLD was significantly associated with significant liver fibrosis (POR: 5.87; CI95%: 2.48 – 13.86; p < 0.001) after adjusted with HBeAg status. Conclusion. NAFLD associated with the higher risk of liver fibrosis in patients with hepatitis B. Modification of lifestyle and potential therapeutic intervention may help in reducing the progression of liver fibrosis. https://scholarhub.ui.ac.id/jpdi/vol10/iss3/2/: chronic hepatitis bliver fibrosisnon-alcoholic fatty liver disease |
| spellingShingle | Andri Sanityoso Sulaiman Irsan Hasan Cosmas Rinaldi A. Lesmana Juferdy Kurniawan Chyntia Olivia M. Jasirwan Saut Horas H. Nababan Kemal Fariz Kalista Gita Aprilicia Rino Alvani Gani Non-Alcoholic Fatty Liver Disease and the Risk of Liver Fibrosis in Chronic Hepatitis B Patients Jurnal Penyakit Dalam Indonesia : chronic hepatitis b liver fibrosis non-alcoholic fatty liver disease |
| title | Non-Alcoholic Fatty Liver Disease and the Risk of Liver Fibrosis in Chronic Hepatitis B Patients |
| title_full | Non-Alcoholic Fatty Liver Disease and the Risk of Liver Fibrosis in Chronic Hepatitis B Patients |
| title_fullStr | Non-Alcoholic Fatty Liver Disease and the Risk of Liver Fibrosis in Chronic Hepatitis B Patients |
| title_full_unstemmed | Non-Alcoholic Fatty Liver Disease and the Risk of Liver Fibrosis in Chronic Hepatitis B Patients |
| title_short | Non-Alcoholic Fatty Liver Disease and the Risk of Liver Fibrosis in Chronic Hepatitis B Patients |
| title_sort | non alcoholic fatty liver disease and the risk of liver fibrosis in chronic hepatitis b patients |
| topic | : chronic hepatitis b liver fibrosis non-alcoholic fatty liver disease |
| url | https://scholarhub.ui.ac.id/jpdi/vol10/iss3/2/ |
| work_keys_str_mv | AT andrisanityososulaiman nonalcoholicfattyliverdiseaseandtheriskofliverfibrosisinchronichepatitisbpatients AT irsanhasan nonalcoholicfattyliverdiseaseandtheriskofliverfibrosisinchronichepatitisbpatients AT cosmasrinaldialesmana nonalcoholicfattyliverdiseaseandtheriskofliverfibrosisinchronichepatitisbpatients AT juferdykurniawan nonalcoholicfattyliverdiseaseandtheriskofliverfibrosisinchronichepatitisbpatients AT chyntiaoliviamjasirwan nonalcoholicfattyliverdiseaseandtheriskofliverfibrosisinchronichepatitisbpatients AT sauthorashnababan nonalcoholicfattyliverdiseaseandtheriskofliverfibrosisinchronichepatitisbpatients AT kemalfarizkalista nonalcoholicfattyliverdiseaseandtheriskofliverfibrosisinchronichepatitisbpatients AT gitaaprilicia nonalcoholicfattyliverdiseaseandtheriskofliverfibrosisinchronichepatitisbpatients AT rinoalvanigani nonalcoholicfattyliverdiseaseandtheriskofliverfibrosisinchronichepatitisbpatients |