CitH3, a Druggable Biomarker for Human Diseases Associated with Acute NETosis and Chronic Immune Dysfunction

CitH3, a Druggable Biomarker for Human Diseases Associated with Acute NETosis and Chronic Immune Dysfunction

Neutrophils are essential components of innate immunity, executing a range of effector functions including phagocytosis, degranulation, and the release of neutrophil extracellular traps (NETs). A key hallmark of NET formation is the presence of citrullinated histone H3 (CitH3), produced by peptidyla...

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Bibliographic Details
Main Authors: Yuchen Chen, Zoe Ann Tetz, Xindi Zeng, Sophia Jihye Go, Wenlu Ouyang, Kyung Eun Lee, Tao Dong, Yongqing Li, Jianjie Ma
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceutics
Subjects:
sepsis
infection
inflammation
ischemia–reperfusion injury
wound healing
autoimmune diseases
Online Access:https://www.mdpi.com/1999-4923/17/7/809
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