Advance on establishment of pathological model of ulcerative colitis
Inflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic, relapsing inflammatory disorder of the gastrointestinal tract with multifactorial etiology. The etiology and pathogenesis of ulcerative colitis are diverse, so it is crucial to explore the pa...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2025.1618260/full |
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| _version_ | 1849222601335898112 |
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| author | Lan Yang Han Gao Dacheng Liu |
| author_facet | Lan Yang Han Gao Dacheng Liu |
| author_sort | Lan Yang |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic, relapsing inflammatory disorder of the gastrointestinal tract with multifactorial etiology. The etiology and pathogenesis of ulcerative colitis are diverse, so it is crucial to explore the pathogenesis through animal models. Selecting appropriate animal models is critical for advancing our understanding of UC pathogenesis and therapeutic strategies. This review discusses various UC animal models and compares their characteristics in relation to disease mechanisms and therapeutic research. |
| format | Article |
| id | doaj-art-2920861191a04305acd67e70530b8b16 |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-2920861191a04305acd67e70530b8b162025-08-26T04:12:50ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-08-011210.3389/fvets.2025.16182601618260Advance on establishment of pathological model of ulcerative colitisLan YangHan GaoDacheng LiuInflammatory bowel disease (IBD), comprising Crohn’s disease (CD) and ulcerative colitis (UC), is a chronic, relapsing inflammatory disorder of the gastrointestinal tract with multifactorial etiology. The etiology and pathogenesis of ulcerative colitis are diverse, so it is crucial to explore the pathogenesis through animal models. Selecting appropriate animal models is critical for advancing our understanding of UC pathogenesis and therapeutic strategies. This review discusses various UC animal models and compares their characteristics in relation to disease mechanisms and therapeutic research.https://www.frontiersin.org/articles/10.3389/fvets.2025.1618260/fullCrohn’s diseaseulcerative colitisanimal modelsetiologypathogenesis |
| spellingShingle | Lan Yang Han Gao Dacheng Liu Advance on establishment of pathological model of ulcerative colitis Frontiers in Veterinary Science Crohn’s disease ulcerative colitis animal models etiology pathogenesis |
| title | Advance on establishment of pathological model of ulcerative colitis |
| title_full | Advance on establishment of pathological model of ulcerative colitis |
| title_fullStr | Advance on establishment of pathological model of ulcerative colitis |
| title_full_unstemmed | Advance on establishment of pathological model of ulcerative colitis |
| title_short | Advance on establishment of pathological model of ulcerative colitis |
| title_sort | advance on establishment of pathological model of ulcerative colitis |
| topic | Crohn’s disease ulcerative colitis animal models etiology pathogenesis |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2025.1618260/full |
| work_keys_str_mv | AT lanyang advanceonestablishmentofpathologicalmodelofulcerativecolitis AT hangao advanceonestablishmentofpathologicalmodelofulcerativecolitis AT dachengliu advanceonestablishmentofpathologicalmodelofulcerativecolitis |