Prevalence and Pathogen Distribution of Neonatal Sepsis Among Very-Low-Birth-Weight Infants
Neonatal sepsis contributes to great mortality and morbidity among very-low-birth-weight (VLBW) infants. Prevalence and pathogen distribution of sepsis in the neonatal intensive care units (NICUs) vary with time and geographic location. Such information serves as a guide for selection of empirical a...
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| Format: | Article |
| Language: | English |
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Elsevier
2012-08-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S187595721200068X |
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| author | Wai Ho Lim Reyin Lien Yhu-Chering Huang Ming-Chou Chiang Ren-Huei Fu Shih-Ming Chu Jen-Fu Hsu Peng-Hong Yang |
| author_facet | Wai Ho Lim Reyin Lien Yhu-Chering Huang Ming-Chou Chiang Ren-Huei Fu Shih-Ming Chu Jen-Fu Hsu Peng-Hong Yang |
| author_sort | Wai Ho Lim |
| collection | DOAJ |
| description | Neonatal sepsis contributes to great mortality and morbidity among very-low-birth-weight (VLBW) infants. Prevalence and pathogen distribution of sepsis in the neonatal intensive care units (NICUs) vary with time and geographic location. Such information serves as a guide for selection of empirical antibiotics coverage.
Methods: This is a case series study performed by retrospective chart review of VLBW infants (birth body weight, BBW, <1500 g) in a medical center during a 5-year period from January 2005 to December 2009. Episodes of positive blood cultures, pathogen distribution and related clinical manifestations were described.
Results: A total of 158 episodes of sepsis were identified from 1042 VLBW infants. Sepsis rate was 152 per 1000 live births. The vast majority of infections (60.7%) were caused by Gram-positive organisms [G(+)], and overall Coagulase-negative staphylococci (CoNS) (52.5%) were the most common pathogen identified. Prevalence for early-onset sepsis (EOS) was 1% and for late-onset sepsis (LOS) was 14.2%. Infants with EOS had a much higher case fatality rate than LOS (40% vs. 4.7%). Escherichia coli (40%) were the leading pathogen of EOS while CoNS (54.7%) was the leading pathogens of LOS. Overall, apnea and/or bradycardia and/or cyanosis (65.8%), poor activity (48.7%), and increased respiratory effort (43.0%) were the most common presenting features of sepsis.
Conclusion: Unlike term infants, Gram-negative organism and E coli were the leading pathogen of EOS among VLBW infants. Judicious and timely use of antibiotic therapy is crucial in the care of VLBW infants. |
| format | Article |
| id | doaj-art-292011d06f134a7f9644e0124308ca1c |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2012-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-292011d06f134a7f9644e0124308ca1c2025-08-20T02:00:43ZengElsevierPediatrics and Neonatology1875-95722012-08-0153422823410.1016/j.pedneo.2012.06.003Prevalence and Pathogen Distribution of Neonatal Sepsis Among Very-Low-Birth-Weight InfantsWai Ho Lim0Reyin Lien1Yhu-Chering Huang2Ming-Chou Chiang3Ren-Huei Fu4Shih-Ming Chu5Jen-Fu Hsu6Peng-Hong Yang7Division of Neonatology, Chang Gung Children's Hospital, School of Medicine, Chang Gung University, Kweishan, Taoyuan, TaiwanDivision of Neonatology, Chang Gung Children's Hospital, School of Medicine, Chang Gung University, Kweishan, Taoyuan, TaiwanDivision of Pediatric Infectious Disease, Chang Gung Children's Hospital, School of Medicine, Chang Gung University, Kweishan, Taoyuan, TaiwanDivision of Neonatology, Chang Gung Children's Hospital, School of Medicine, Chang Gung University, Kweishan, Taoyuan, TaiwanDivision of Neonatology, Chang Gung Children's Hospital, School of Medicine, Chang Gung University, Kweishan, Taoyuan, TaiwanDivision of Neonatology, Chang Gung Children's Hospital, School of Medicine, Chang Gung University, Kweishan, Taoyuan, TaiwanDivision of Neonatology, Chang Gung Children's Hospital, School of Medicine, Chang Gung University, Kweishan, Taoyuan, TaiwanDivision of Neonatology, Chang Gung Children's Hospital, School of Medicine, Chang Gung University, Kweishan, Taoyuan, TaiwanNeonatal sepsis contributes to great mortality and morbidity among very-low-birth-weight (VLBW) infants. Prevalence and pathogen distribution of sepsis in the neonatal intensive care units (NICUs) vary with time and geographic location. Such information serves as a guide for selection of empirical antibiotics coverage. Methods: This is a case series study performed by retrospective chart review of VLBW infants (birth body weight, BBW, <1500 g) in a medical center during a 5-year period from January 2005 to December 2009. Episodes of positive blood cultures, pathogen distribution and related clinical manifestations were described. Results: A total of 158 episodes of sepsis were identified from 1042 VLBW infants. Sepsis rate was 152 per 1000 live births. The vast majority of infections (60.7%) were caused by Gram-positive organisms [G(+)], and overall Coagulase-negative staphylococci (CoNS) (52.5%) were the most common pathogen identified. Prevalence for early-onset sepsis (EOS) was 1% and for late-onset sepsis (LOS) was 14.2%. Infants with EOS had a much higher case fatality rate than LOS (40% vs. 4.7%). Escherichia coli (40%) were the leading pathogen of EOS while CoNS (54.7%) was the leading pathogens of LOS. Overall, apnea and/or bradycardia and/or cyanosis (65.8%), poor activity (48.7%), and increased respiratory effort (43.0%) were the most common presenting features of sepsis. Conclusion: Unlike term infants, Gram-negative organism and E coli were the leading pathogen of EOS among VLBW infants. Judicious and timely use of antibiotic therapy is crucial in the care of VLBW infants.http://www.sciencedirect.com/science/article/pii/S187595721200068Xneonatal intensive care unitsepsisvery-low-birth-weight infants |
| spellingShingle | Wai Ho Lim Reyin Lien Yhu-Chering Huang Ming-Chou Chiang Ren-Huei Fu Shih-Ming Chu Jen-Fu Hsu Peng-Hong Yang Prevalence and Pathogen Distribution of Neonatal Sepsis Among Very-Low-Birth-Weight Infants Pediatrics and Neonatology neonatal intensive care unit sepsis very-low-birth-weight infants |
| title | Prevalence and Pathogen Distribution of Neonatal Sepsis Among Very-Low-Birth-Weight Infants |
| title_full | Prevalence and Pathogen Distribution of Neonatal Sepsis Among Very-Low-Birth-Weight Infants |
| title_fullStr | Prevalence and Pathogen Distribution of Neonatal Sepsis Among Very-Low-Birth-Weight Infants |
| title_full_unstemmed | Prevalence and Pathogen Distribution of Neonatal Sepsis Among Very-Low-Birth-Weight Infants |
| title_short | Prevalence and Pathogen Distribution of Neonatal Sepsis Among Very-Low-Birth-Weight Infants |
| title_sort | prevalence and pathogen distribution of neonatal sepsis among very low birth weight infants |
| topic | neonatal intensive care unit sepsis very-low-birth-weight infants |
| url | http://www.sciencedirect.com/science/article/pii/S187595721200068X |
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