Engineered Prx-LCA2 fusion protein restores oxidative skin damage via enhanced intracellular peroxidase delivery

Engineered Prx-LCA2 fusion protein restores oxidative skin damage via enhanced intracellular peroxidase delivery

Abstract This study developed a novel antioxidant fusion protein Prx-LCA2 by conjugating peroxidase Prx with the LCA2 carrier derived from Escherichia coli heat-labile enterotoxin, aiming to achieve efficient intracellular delivery for oxidative damage remediation. The fusion protein Prx-LCA2 was su...

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Bibliographic Details
Main Authors: Di Liu, Yafen Zhan, Jiaqi Qu, Hongping Qiao, Na Li, Yeli Zhang, Xiaoying Wu
Format: Article
Language:English
Published: SpringerOpen 2025-06-01
Series:AMB Express
Subjects:
LCA2 protein carrier
Peroxidase activity
Oxidative stress
Skin antioxidant defense
Online Access:https://doi.org/10.1186/s13568-025-01906-5
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