Liver-expressed antimicrobial peptide 2 is a hepatokine regulated by ghrelin, nutrients, and body weight

Liver-expressed antimicrobial peptide 2 is a hepatokine regulated by ghrelin, nutrients, and body weight

Abstract Liver-expressed antimicrobial peptide 2 (LEAP2) is a peptide that counteracts the hunger hormone ghrelin-induced functions. Recently, we showed that vertical sleeve gastrectomy (VSG) did not alter the serum LEAP2 concentration in individuals with obesity. Here, we investigated the effects o...

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Bibliographic Details
Main Authors: Md Nurul Islam, Hiroki Nabekura, Hiroaki Ueno, Takahiro Nishida, Atsushi Nanashima, Hideyuki Sakoda, Weidong Zhang, Masamitsu Nakazato
Format: Article
Language:English
Published: Nature Portfolio 2024-10-01
Series:Scientific Reports
Subjects:
LEAP2
Ghrelin
Hepatokine
Diabetes
Obesity
Vertical sleeve gastrectomy
Online Access:https://doi.org/10.1038/s41598-024-74048-6
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