Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases
Despite development of medicine, cardiovascular diseases (CVDs) are still the leading cause of mortality and morbidity worldwide. Over the past 10 years, various stem cells have been utilized in therapeutic strategies for the treatment of CVDs. CVDs are characterized by a broad range of pathological...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2016/4285938 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549220937105408 |
|---|---|
| author | Chang Youn Lee Ran Kim Onju Ham Jihyun Lee Pilseog Kim Seokyeon Lee Sekyung Oh Hojin Lee Minyoung Lee Jongmin Kim Woochul Chang |
| author_facet | Chang Youn Lee Ran Kim Onju Ham Jihyun Lee Pilseog Kim Seokyeon Lee Sekyung Oh Hojin Lee Minyoung Lee Jongmin Kim Woochul Chang |
| author_sort | Chang Youn Lee |
| collection | DOAJ |
| description | Despite development of medicine, cardiovascular diseases (CVDs) are still the leading cause of mortality and morbidity worldwide. Over the past 10 years, various stem cells have been utilized in therapeutic strategies for the treatment of CVDs. CVDs are characterized by a broad range of pathological reactions including inflammation, necrosis, hyperplasia, and hypertrophy. However, the causes of CVDs are still unclear. While there is a limit to the currently available target-dependent treatments, the therapeutic potential of stem cells is very attractive for the treatment of CVDs because of their paracrine effects, anti-inflammatory activity, and immunomodulatory capacity. Various studies have recently reported increased therapeutic potential of transplantation of microRNA- (miRNA-) overexpressing stem cells or small-molecule-treated cells. In addition to treatment with drugs or overexpressed miRNA in stem cells, stem cell-derived extracellular vesicles also have therapeutic potential because they can deliver the stem cell-specific RNA and protein into the host cell, thereby improving cell viability. Here, we reported the state of stem cell-based therapy for the treatment of CVDs and the potential for cell-free based therapy. |
| format | Article |
| id | doaj-art-2912e16efa704e9eb279fabc28289b80 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-2912e16efa704e9eb279fabc28289b802025-02-03T06:11:42ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/42859384285938Therapeutic Potential of Stem Cells Strategy for Cardiovascular DiseasesChang Youn Lee0Ran Kim1Onju Ham2Jihyun Lee3Pilseog Kim4Seokyeon Lee5Sekyung Oh6Hojin Lee7Minyoung Lee8Jongmin Kim9Woochul Chang10Department of Integrated Omics for Biomedical Sciences, Graduate School, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-759, Republic of KoreaDepartment of Biology Education, College of Education, Pusan National University, Busan 609-735, Republic of KoreaInstitute for Bio-Medical Convergence, Catholic Kwandong University International St. Mary’s Hospital, Incheon 404-834, Republic of KoreaDepartment of Biology Education, College of Education, Pusan National University, Busan 609-735, Republic of KoreaDepartment of Biology Education, College of Education, Pusan National University, Busan 609-735, Republic of KoreaDepartment of Biology Education, College of Education, Pusan National University, Busan 609-735, Republic of KoreaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USADepartment of Molecular Physiology, College of Pharmacy, Kyungpook National University, Daegu 702-701, Republic of KoreaDepartment of Life Systems, Sookmyung Women’s University, 52 Hyochangwon-gil, Yongsan-gu, Seoul 140-742, Republic of KoreaDepartment of Biology Education, College of Education, Pusan National University, Busan 609-735, Republic of KoreaDespite development of medicine, cardiovascular diseases (CVDs) are still the leading cause of mortality and morbidity worldwide. Over the past 10 years, various stem cells have been utilized in therapeutic strategies for the treatment of CVDs. CVDs are characterized by a broad range of pathological reactions including inflammation, necrosis, hyperplasia, and hypertrophy. However, the causes of CVDs are still unclear. While there is a limit to the currently available target-dependent treatments, the therapeutic potential of stem cells is very attractive for the treatment of CVDs because of their paracrine effects, anti-inflammatory activity, and immunomodulatory capacity. Various studies have recently reported increased therapeutic potential of transplantation of microRNA- (miRNA-) overexpressing stem cells or small-molecule-treated cells. In addition to treatment with drugs or overexpressed miRNA in stem cells, stem cell-derived extracellular vesicles also have therapeutic potential because they can deliver the stem cell-specific RNA and protein into the host cell, thereby improving cell viability. Here, we reported the state of stem cell-based therapy for the treatment of CVDs and the potential for cell-free based therapy.http://dx.doi.org/10.1155/2016/4285938 |
| spellingShingle | Chang Youn Lee Ran Kim Onju Ham Jihyun Lee Pilseog Kim Seokyeon Lee Sekyung Oh Hojin Lee Minyoung Lee Jongmin Kim Woochul Chang Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases Stem Cells International |
| title | Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases |
| title_full | Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases |
| title_fullStr | Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases |
| title_full_unstemmed | Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases |
| title_short | Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases |
| title_sort | therapeutic potential of stem cells strategy for cardiovascular diseases |
| url | http://dx.doi.org/10.1155/2016/4285938 |
| work_keys_str_mv | AT changyounlee therapeuticpotentialofstemcellsstrategyforcardiovasculardiseases AT rankim therapeuticpotentialofstemcellsstrategyforcardiovasculardiseases AT onjuham therapeuticpotentialofstemcellsstrategyforcardiovasculardiseases AT jihyunlee therapeuticpotentialofstemcellsstrategyforcardiovasculardiseases AT pilseogkim therapeuticpotentialofstemcellsstrategyforcardiovasculardiseases AT seokyeonlee therapeuticpotentialofstemcellsstrategyforcardiovasculardiseases AT sekyungoh therapeuticpotentialofstemcellsstrategyforcardiovasculardiseases AT hojinlee therapeuticpotentialofstemcellsstrategyforcardiovasculardiseases AT minyounglee therapeuticpotentialofstemcellsstrategyforcardiovasculardiseases AT jongminkim therapeuticpotentialofstemcellsstrategyforcardiovasculardiseases AT woochulchang therapeuticpotentialofstemcellsstrategyforcardiovasculardiseases |