Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases

Despite development of medicine, cardiovascular diseases (CVDs) are still the leading cause of mortality and morbidity worldwide. Over the past 10 years, various stem cells have been utilized in therapeutic strategies for the treatment of CVDs. CVDs are characterized by a broad range of pathological...

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Main Authors: Chang Youn Lee, Ran Kim, Onju Ham, Jihyun Lee, Pilseog Kim, Seokyeon Lee, Sekyung Oh, Hojin Lee, Minyoung Lee, Jongmin Kim, Woochul Chang
Format: Article
Language:English
Published: Wiley 2016-01-01
Series:Stem Cells International
Online Access:http://dx.doi.org/10.1155/2016/4285938
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author Chang Youn Lee
Ran Kim
Onju Ham
Jihyun Lee
Pilseog Kim
Seokyeon Lee
Sekyung Oh
Hojin Lee
Minyoung Lee
Jongmin Kim
Woochul Chang
author_facet Chang Youn Lee
Ran Kim
Onju Ham
Jihyun Lee
Pilseog Kim
Seokyeon Lee
Sekyung Oh
Hojin Lee
Minyoung Lee
Jongmin Kim
Woochul Chang
author_sort Chang Youn Lee
collection DOAJ
description Despite development of medicine, cardiovascular diseases (CVDs) are still the leading cause of mortality and morbidity worldwide. Over the past 10 years, various stem cells have been utilized in therapeutic strategies for the treatment of CVDs. CVDs are characterized by a broad range of pathological reactions including inflammation, necrosis, hyperplasia, and hypertrophy. However, the causes of CVDs are still unclear. While there is a limit to the currently available target-dependent treatments, the therapeutic potential of stem cells is very attractive for the treatment of CVDs because of their paracrine effects, anti-inflammatory activity, and immunomodulatory capacity. Various studies have recently reported increased therapeutic potential of transplantation of microRNA- (miRNA-) overexpressing stem cells or small-molecule-treated cells. In addition to treatment with drugs or overexpressed miRNA in stem cells, stem cell-derived extracellular vesicles also have therapeutic potential because they can deliver the stem cell-specific RNA and protein into the host cell, thereby improving cell viability. Here, we reported the state of stem cell-based therapy for the treatment of CVDs and the potential for cell-free based therapy.
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spelling doaj-art-2912e16efa704e9eb279fabc28289b802025-02-03T06:11:42ZengWileyStem Cells International1687-966X1687-96782016-01-01201610.1155/2016/42859384285938Therapeutic Potential of Stem Cells Strategy for Cardiovascular DiseasesChang Youn Lee0Ran Kim1Onju Ham2Jihyun Lee3Pilseog Kim4Seokyeon Lee5Sekyung Oh6Hojin Lee7Minyoung Lee8Jongmin Kim9Woochul Chang10Department of Integrated Omics for Biomedical Sciences, Graduate School, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-759, Republic of KoreaDepartment of Biology Education, College of Education, Pusan National University, Busan 609-735, Republic of KoreaInstitute for Bio-Medical Convergence, Catholic Kwandong University International St. Mary’s Hospital, Incheon 404-834, Republic of KoreaDepartment of Biology Education, College of Education, Pusan National University, Busan 609-735, Republic of KoreaDepartment of Biology Education, College of Education, Pusan National University, Busan 609-735, Republic of KoreaDepartment of Biology Education, College of Education, Pusan National University, Busan 609-735, Republic of KoreaDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USADepartment of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USADepartment of Molecular Physiology, College of Pharmacy, Kyungpook National University, Daegu 702-701, Republic of KoreaDepartment of Life Systems, Sookmyung Women’s University, 52 Hyochangwon-gil, Yongsan-gu, Seoul 140-742, Republic of KoreaDepartment of Biology Education, College of Education, Pusan National University, Busan 609-735, Republic of KoreaDespite development of medicine, cardiovascular diseases (CVDs) are still the leading cause of mortality and morbidity worldwide. Over the past 10 years, various stem cells have been utilized in therapeutic strategies for the treatment of CVDs. CVDs are characterized by a broad range of pathological reactions including inflammation, necrosis, hyperplasia, and hypertrophy. However, the causes of CVDs are still unclear. While there is a limit to the currently available target-dependent treatments, the therapeutic potential of stem cells is very attractive for the treatment of CVDs because of their paracrine effects, anti-inflammatory activity, and immunomodulatory capacity. Various studies have recently reported increased therapeutic potential of transplantation of microRNA- (miRNA-) overexpressing stem cells or small-molecule-treated cells. In addition to treatment with drugs or overexpressed miRNA in stem cells, stem cell-derived extracellular vesicles also have therapeutic potential because they can deliver the stem cell-specific RNA and protein into the host cell, thereby improving cell viability. Here, we reported the state of stem cell-based therapy for the treatment of CVDs and the potential for cell-free based therapy.http://dx.doi.org/10.1155/2016/4285938
spellingShingle Chang Youn Lee
Ran Kim
Onju Ham
Jihyun Lee
Pilseog Kim
Seokyeon Lee
Sekyung Oh
Hojin Lee
Minyoung Lee
Jongmin Kim
Woochul Chang
Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases
Stem Cells International
title Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases
title_full Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases
title_fullStr Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases
title_full_unstemmed Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases
title_short Therapeutic Potential of Stem Cells Strategy for Cardiovascular Diseases
title_sort therapeutic potential of stem cells strategy for cardiovascular diseases
url http://dx.doi.org/10.1155/2016/4285938
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