The KIT ligand KITLG promotes portal vein tumor thrombosis by up-regulating COL4A1 through STAT3-SMAD2 signaling in hepatocellular carcinoma

The KIT ligand KITLG promotes portal vein tumor thrombosis by up-regulating COL4A1 through STAT3-SMAD2 signaling in hepatocellular carcinoma

Portal vein tumor thrombosis (PVTT), a severe complication of hepatocellular carcinoma (HCC), markedly influences patient prognosis by fostering a hypercoagulable state. However, its molecular underpinnings remain largely unexplored. This study sheds light on the critical role of the KIT ligand (KIT...

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Bibliographic Details
Main Authors: Feifei Mao, Yuqiang Cheng, Kang Wang, Zongtao Chai, Lei Guo, Yanyan Xu, Xue Chen, Jie Shi, Weixing Guo, Junling Liu, Shuqun Cheng
Format: Article
Language:English
Published: Compuscript Ltd 2024-05-01
Series:Acta Materia Medica
Online Access:https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0049
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